History of Narcolepsy
Brief timeline of research and Stanford contribution
1877
1880
1902
1935
1960
1973
1977
1983
1985
1992
1998
1999
2000
2000
2001
2009
2010
2010
2013
2013
First description in the medical literature
Gelineau called the disorder “narcolepsy”
Loewenfeld coined the term “cataplexy”
First use of amphetamines in the treatment of narcolepsy
Description of Sleep Onset REM periods in a narcoleptic subject
First report of a narcoleptic dog
Description of the Multiple Latency Test
Association of narcolepsy with HLA-DR2
Monoaminergic and cholinergic imbalance in narcolepsy
Association of narcolepsy with HLA-DQB1*06:02
Identification of hypocretins/orexins and their receptors
Hypocretin system mutations cause narcolepsy in mice and dogs
Human narcolepsy is also associated with low CSF hypocretin-1
Human narcolepsy is associated with a loss of hypocretin cells
HLA effects additional to DQB1*06:02 in narcolepsy
Genome Wide Associations identifies T-Cell receptor as additional susceptibility locus
Association of narcolepsy onsets with 2009 H1N1 infections and vaccinations
Allele competition explains protective effects of some DQ1 haplotypes
Identification of hypocretin autoreactive CD4+T cells in narcolepsy
Molecular mimicry between H1N1 and hypocretin autoantigen
Stanford contributions noted in bold