History of Narcolepsy

Brief timeline of research and Stanford contribution

First description in the medical literature

Gelineau called the disorder “narcolepsy”

Loewenfeld coined the term “cataplexy”

First use of amphetamines in the treatment of narcolepsy

Description of Sleep Onset REM periods in a narcoleptic subject

First report of a narcoleptic dog

Description of the Multiple Latency Test

Association of narcolepsy with HLA-DR2

Monoaminergic and cholinergic imbalance in narcolepsy

Association of narcolepsy with HLA-DQB1*06:02

Identification of hypocretins/orexins and their receptors

Hypocretin system mutations cause narcolepsy in mice and dogs

Human narcolepsy is also associated with low CSF hypocretin-1

Human narcolepsy is associated with a loss of hypocretin cells

HLA effects additional to DQB1*06:02 in narcolepsy

Genome Wide Associations identifies T-Cell receptor as additional susceptibility locus

Association of narcolepsy onsets with 2009 H1N1 infections and vaccinations

Allele competition explains protective effects of some DQ1 haplotypes

Identification of hypocretin autoreactive CD4+T cells in narcolepsy

Molecular mimicry between H1N1 and hypocretin autoantigen


Stanford contributions noted in bold