Research in Nakauchi Lab
Translation of our discoveries in basic research into practical medical applications
Dr. Hiromitsu Nakauchi
In the Nakauchi Lab, we are working on uncovering new diseases, elucidating the causes of disease, and developing therapeutic modalities by connecting the knowledge and methodology of basic science including immunology, molecular biology, cell biology, and developmental engineering with clinical medicine. Our ultimate goal is to contribute to establishing new frontiers of stem cell therapy and to make clinical applications of stem cells a reality.
Current work in the Nakauchi Lab includes;
1. Elucidation of heterogeneity and hierarchy in hematopoietic stem cells
2. Rejuvenation of antigen specific T cells for efficient immunotherapy
3. Generation of organs from iPS cells by way of blastocyst complementation
With respect to education, we aim to establish an environment where individuals can make the utmost use of their interests, personalities and abilities in order to foster potential researchers, as a human resource, with a succession of creative studies in the field of bioscience.
*Research fellow (preferably self-funded) with research interests in stem cell biology, hematology, developmental biology and immunology fields are encouraged to contact us to further discuss specific projects available.
"Cas9-AAV6 gene correction of beta-globin in autologous HSCs improves sickle cell disease erythropoiesis in mice" Nature Communications 2021
"Generation of Functional Organs Using a Cell-Competitive Niche in Intra- and Inter-species Rodent Chimeras" Cell Stem Cell 2021
"Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation" Nature, May. 2019
"Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats" Nature Communications, Feb. 2019
"Intra-embryo Gene Cassette Knockin by CRISPR/Cas9-Mediated Genome Editing with Adeno-Associated Viral Vector" iScience, Nov. 2018
"An interspecies barrier to tetraploid complementation and chimera formation" Scientific Reports, Oct. 2018
"Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation" Stem Cell Reports, Oct. 2018
"Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress" Cell Stem Cell, May 2018
"Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment" Cell Stem Cell, Apr. 2018