PhySH "Physician Scientist Hour"

INDE 217 : Physician Scientist Hour (PhySH)
Mondays at 12:30pm - 1:20pm

Due to the COVID-19 pandemic, PhySH will be virtual for the 2020-2021 academic year (via Zoom). We will provide updates as information becomes available.

Please register for PhySH - INDE 217
(You are not required to register to attend.)

You might also be interested in the TRAM lecture series, which hosts speakers who are recognized leaders in translational research and applied medicine.  Please see the Translational Research and Applied Medicine website for more information.

Spring 2021 PhySH Schedule

(We will provide updates as information becomes available).

Laura Dassama
April 5, 2021
Progress Toward the Creation of Universally Effective  Fetal Hemoglobin Inducers for Sickle Cell Disease
Dr. Dassama is a bioinorganic chemist and structural biologist who uses tools of chemistry and physics to provide molecular insights into complex biological processes. Her research interests include mitigating bacterial multidrug resistance and developing therapies for sickle cell disease. 

Christopher Barnes
April 19, 2021
Structural Biology in the Age of COVID-19
Dr. Barnes' work is focused on resolving fundamental questions about the mechanism by which the general transcription factors regulate RNA Polymerase II (Pol II) activity. Due to the size and complexity of such systems, he utilized unique techniques to reconstitute and achieve high-resolution structural information. He purified, assembled, and crystallized Pol II complexes for data collection at synchrotron and X-ray free electron laser sources, while also developing transmission electron microscopy methods.

PJ Utz
April 26, 2021
Autoantibodies and Autoimmunity in COVID-19
Dr. Utz’s research focuses on the immune system of patients with immunodeficiency disorders, infections, and autoimmune diseases and mixed connective tissue disease. His lab develops bench-to-bedside technologies, including diagnostics and therapeutics, for human immune diseases. His lab is also active in vaccine biology, both for inducing protective immunity to pathogens and for turning off immune responses in autoimmune diseases.

Matt Porteus
May 10, 2021
From Bench to Phase I: Responsible Translational Research
Dr. Porteus’ research focuses on developing genome editing by homologous recombination as curative therapy for children with genetic diseases but also has interests in the clonal dynamics of heterogeneous populations and the use of genome editing to better understand diseases that affect children including infant leukemias and genetic diseases that affect the muscle.

Katrin Svensson
May 17, 2021
Exploring the Secretome For New Metabolic Hormones
Dr. Svensson's research is dedicated to the discovery of new fundamental pathways of energy regulation. Her lab is using a combination of multi-omics, gene editing and physiology approaches to better understand how to target complex diseases such as aging, metabolic diseases, and cancer.

Vivien Cheung
May 24, 2021
From RNA Biology to Rare Disease:  Journey of a Physician-Scientist
Dr. Cheung is an RNA biologist and child neurologist.  Dr. Cheung’s laboratory has a long-standing interest in gene regulation.  Her group showed that expression levels of human genes can be studied as quantitative traits.  This enabled the mapping of gene regulators without a priori knowledge of the underlying mechanisms, and facilitated the identification of regulatory variants that affect disease susceptibility.  This project on the genetics of human gene expression led to her current studies of the regulatory role of RNA sequences and structures.  This includes determining how dysregulation of a nucleic-acid structure, R-loop, affects motor neurons in a juvenile-onset amyotrophic lateral sclerosis. 

Winter 2021 PhySH Schedule

G2 Presentations: Vipul Vachharajani; Andrea Garofalo
January 11, 2021

Vipul Vachharajani
Single-Molecule Force Spectroscopy of Epithelial Cell Adhesion Molecules
Lab of Alex Dunn, PhD
Program in Biophysics

Andrea Garofalo
Deep Sequencing of Cell-Free DNA for Noninvasive Detection of Immunosuppression-Related Lymphoid Malignancies
Lab of Ash Alizadeh, MD, PhD
Program in Cancer Biology

Elen Yeh
January 25, 2021
A Path Less Traveled
Dr. Yeh’s research focuses on the apicoplast, a prokaryotically-derived plastid organelle unique to Plasmodium (and other pathogenic Apicomplexa parasites) and a key anti-malarial drug target. Her laboratory's goal is to elucidate apicoplast biology, function, and role in pathogenesis with the ultimate goal of realizing the potential of the apicoplast as a therapeutic target. 

G2 Presentation: Alvaro Amorin; David Wang
February 1, 2021

Alvaro Amorin
Dual Stem Cell Therapy for Krabbe Disease
Lab of Natalia Gomez Ospina, MD, PhD
Program in Stem Cell Biology & Regenerative Medicine

David Wang
The Role of Neuronal Activity in Building Brain Circuits
Lab of Liqun Luo, PhD
Department of Biology

Paul George
March 1, 2021
Emerging As a Physician Scientist:  A Non-Linear Path to a Stimulating Career
Dr. George's lab focuses on improving stroke diagnostics as well as engineering new methods to enhance stroke recovery. Their primary focus is applying novel bioengineering techniques to understand the mechanisms of neural recovery (primarily in stroke) and discovering methods to improve patient recovery. They use rodent models of stroke combined with biomaterial techniques, stem cell transplants, and microfabrication to achieve these aims and evaluate our methods with behavior testing and various imaging techniques. Their goal is to translate these findings into clinical trials to help stroke patients.

Catherine Blish
March 8, 2021
Grant Writing: F30
The goal of Dr. Blish’s research is to develop new methods to prevent and control infectious diseases through better understanding of human immunology. The lab has several major areas of ongoing investigation: understanding the diversity and biology of human natural killer (NK) cells; defining the role of NK cells in viral immunity; and immune signatures of human pregnancy.

Autumn 2020 PhySH Schedule

Electron Kebebew
September 14,  2020
What to Investigate and Why?
Dr. Kebebew is the Harry A. Oberhelman, Jr and Mark L. Welton Professor of Surgery and is Chief of the Division of General Surgery & Lab Director at Stanford. Dr. Kebebew’s translational and clinical investigations have three main scientific goals: 1) to develop effective therapies for fatal, rare and neglected endocrine cancers, 2) to identify new methods, strategies and technologies for improving the diagnosis and treatment of endocrine neoplasms and the prognostication of endocrine cancers, and 3) to develop methods for precision treatment of endocrine tumors.

G2 Presentation: Maria Filsinger Interrante
September 21, 2020
Targeting the Prehairpin Intermediate of HIV-1 Fusion Towards Development of a Prophylactic Vaccine
Lab of Peter Kim, PhD
Program in Biophysics

Taia Wang
October 5, 2020
Reflections and Q&A on My Physician-Scientist Training Path and Transition to a Faculty Position
Dr. Wang’s research is aimed at defining mechanisms in human immunity and disease. The Wang laboratory uses in vivo and in vitro systems to study how antibodies can modulate viral infections or anti-viral vaccine responses through signaling interactions with Fc gamma receptors (FcγRs). The overarching goal of projects in the Wang lab is to elucidate FcγR pathways that can be harnessed towards the development of enhanced vaccines and therapeutics.

G2 Presentations: Ved Topkar; Kathryn Wu
October 12, 2020

Ved Topkar
Structural Characterization of mRNA Transport in Oligodendrocytes
Lab of Rhiju Das, PhD
Program in Biophysics

Kathryn Wu
How Schwann Cells Sort and Myelinate Axons
Lab of Brad Zuchero, PhD
Program in Neurosciences

Steve Goodman #1
October 19, 2020
Research Reproducibility - Definitions and  Practice of “Rigor and Reproducibility” in Proposals and in Lab and Clinical Research
Dr. Goodman's research concerns the proper measurement, conceptualization and synthesis of research evidence, with particular emphasis on Bayesian approaches to quantitation, and qualitative approaches arising from the philosophy of science. He is also interested in developing methods to use shared data to confirm and extend published science, as well as to explore new hypotheses. He also has worked on the connections between ethics and scientific methods, particularly in the domain of interventional research, and policy making.

G2 Presentations: Angela Zhang; Shivam Verma
October 26, 2020

Angela Zhang
Developing Label Free Methods to Characterize Induced Pluripotent Stem Cell Derived Cardiomyocytes
Labs of Joseph Wu, MD, PhD, and Russ Altman, MD, PhD
Program in Biomedical Informatics

Shivam Verma
Templated Production of Single-Stranded DNA in Mammalian Cells
Lab of  Carolyn Bertozzi, PhD
Department of Chemical and Systems Biology

Tom Rando
November 2, 2020
The Journey of a Physician Scientist: Random Walks and Infinite Sample Space
Dr. Rando's research focuses on tissue-specific stem cells in aging and disease, and on pathogenetic mechanisms and gene therapy for muscular dystrophies. His research on aging has demonstrated that it is possible to identify biochemical stimuli that can induce stem cells in old tissues to repair injuries as effectively as in young tissues, and this work has broad implications for the fields of regenerative medicine and stem cell transplantation.

G2 Presentations: Aaron WIlk; Tim Chai
November 9, 2020

Aaron Wilk
Seq-ing Answers to COVID-19: Lessons From Multimodal Immune Profiling
Lab of Catherine Blish, MD, PhD
Program in Immunology

Tim Chai
How T Cells Communicate With Cancer Cells
Lab of Irving Weissman, MD
Program in Cancer Biology

MSTP Diversity Working Group (DWG)
November 16, 20200
DWG's Structure and Goals for the Upcoming Year
The mission of the MSTP Diversity Working Group (DWG) is to promote and support diversity of all kinds, at all phases of the physician scientist training process, by fostering and advocating for the equal treatment of all prospective and current MSTP students in recruitment, admission, retention and career placement of MSTP students. 

Steve Goodman #2
November 30, 2020
Design, Data Analysis and Data Management
Dr. Goodman's research concerns the proper measurement, conceptualization and synthesis of research evidence, with particular emphasis on Bayesian approaches to quantitation, and qualitative approaches arising from the philosophy of science. He is also interested in developing methods to use shared data to confirm and extend published science, as well as to explore new hypotheses. He also has worked on the connections between ethics and scientific methods, particularly in the domain of interventional research, and policy making.