Mormino Lab Open Positions

Early Tau accumulation is detected within the medial temporal lobe using Tau PET imaging. 

Data Analyst

The Mormino Laboratory within the Department of Neurology and Neurological Sciences is seeking a Data Analyst I to work on large scale neuroimaging harmonization efforts to understand Alzheimer’s disease pathology in human aging and neurological diseases. These projects reflect multisite efforts to curate and harmonize imaging data to enable large data efforts in the national Alzheimer’s Disease Research Center (ADRC) program along with the Alzheimer’s Disease Sequencing Project Harmonization Consortium (ADSP-HC). Our research is focused on improving the diagnosis and monitoring of disease, enabling early detection, and understanding the contributions of early pathology to cognitive decline in human aging. Main duties include the curation and analysis of large multisite retrospective MRI and PET imaging data. 

Clinical Research Coordinator Associate

The Mormino Laboratory within the Department of Neurology and Neurological Sciences is seeking a Clinical Research Coordinator Associate (CRC-A) to work on a large multimodality imaging research study that combines MRI and PET imaging to understand Alzheimer’s disease pathology and memory decline in human aging (The Stanford Aging and Memory Study, SAMS). This project is a collaboration between the Mormino Laboratory in the Department of Neurology and the Wagner Laboratory in the Department of Psychology.  This study involves multiple participant visits to collect neuroimaging and lumbar puncture data from human participants.  Our research is focused on improving the diagnosis and monitoring of disease, enabling early detection, and understanding the contributions of early pathology to cognitive decline in human aging.  Main duties include in-person and telephone recruitment of research participants; obtaining informed consent; scheduling and coordination of research participant visits; maintaining longitudinal contact with participants by phone, email and other means; MRI data collection; neuroimaging analysis; neuropsychological data collection/scoring/entry.

The Stanford Aging and Memory Study: Postdoctoral Fellows Positions

The Stanford Aging and Memory Study (SAMS) is a large multimodal imaging-biofluid study of human aging.  Two hundred clinically normal older individuals have already completed a baseline study that involved high-resolution imaging (3T fMRI and 7T) and biofluid assessments (CSF, plasma).  We will be launching a longitudinal arm to this study in early 2022, which will include repetition of previously collected measures, addition of tau PET, and opportunities for inclusion of novel task-based assessments.  We are interested in functional, structural, and molecular changes that influence age-related memory decline and progression to clinical impairment, as well as non-clinical age-related neural changes that impact memory.

We are seeking two postdocs to join our team of scientists:

Postdoctoral fellow –– Biomarker lead: SAMS will examine change over time in metrics related to early AD pathology (CSF measures of amyloid and ptau) as well as exploratory targets using high-throughput proteomic assays (CSF and plasma), high-resolution 7T structural imaging derived measures (medial temporal lobe subfields), and sensitive behavioral memory paradigms.  The ideal Biomarker lead will integrate across multiple modalities to elucidate trajectories of normal and pathological aging. 

Postdoctoral fellow –– fMRI lead: One key aim in SAMS is to understand how multivariate functional metrics of pattern separation, pattern completion, and cortical reinstatement explain differences in memory and change as a function of early AD pathology.  The fMRI lead will leverage baseline and longitudinal fMRI data to evaluate age-related changes to these, and associated frontoparietal, neural mechanisms, and to relate these changes to memory performance and markers of amyloid and tau accumulation (CSF and PET).

The postdoctoral fellows will be jointly mentored by Drs. Beth Mormino (Dept of Neurology) and Anthony Wagner (Dept of Psychology).

Required skills

fMRI lead: Experience with multivariate fMRI analysis and background in the cognitive neuroscience of memory

Biomarker lead: Experience with longitudinal statistical modeling and previous work with neuroimaging data (fMRI, structural MRI, or PET).

Both: Linux, R, python; background in aging/Alzheimer's disease or keen interest in transitioning to cognitive aging research

Please send cover letter, CV, and contact info for referees to Drs. Mormino (bmormino@stanford.edu) and Wagner (awagner@stanford.edu).

Clinical Research Coordinator for MRI and PET Studies

The Mormino Laboratory within the Department of Neurology and Neurological Sciences is seeking a Clinical Research Coordinator Associate (CRC) to work on research studies that combine MRI and PET imaging to understand Alzheimer’s disease pathology and neuroinflammation in human aging and neurodegenerative diseases. Our research is focused on improving the diagnosis and monitoring of disease, enabling early detection, and understanding the contributions of early pathology to cognitive decline in human aging. The CRC will work on research investigating early Alzheimer’s disease changes among normal healthy individuals as well as in patient populations such as mild cognitive impairment, Alzheimer’s disease, and related neurodegenerative disorders. Main duties include in-person and telephone recruitment of research participants; obtaining informed consent; scheduling and coordination of research participant visits; maintaining longitudinal contact with participants by phone, email and other means; MRI data collection; neuroimaging analysis; neuropsychological data collection/scoring/entry.