Non-invasively investigating the therapeutic response of human cancers
We are a translational research laboratory using analysis of human samples to identify critical mediators of treatment resistance that can be validated in preclinical models and targeted to enhance the efficacy of cancer therapy.
We use next-generation sequencing to understand the genetic underpinnings and expression signatures that determine response to cancer therapy.
We use circulating tumor DNA to gain unique insights into tumor dynamics over the course of therapy and identify mechanisms of therapeutic resistance.
We use CRISPR/Cas9 technology to rapidly generate novel primary mouse models to understand the mechanisms of therapeutic resistance and test new therapies.
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