RELATE - REAL World Evidence for Kidney Care

RELATE is a REAL World Treatment Evidence collaborative bringing together investigators at Stanford Medicine and the Veterans Affairs Palo Alto Healthcare System to assess the safety, effectiveness and quality of kidney disease treatments. 

The goal of RELATE is to advance evidence-based patient-centered kidney care.


We seek to understand the benefits and harms of kidney disease treatments for patients that doctors treat in everyday practice. These ‘real world’ patients are often older and have more chronic conditions than the people who are included in clinical trials, and as a result, doctors often struggle to recommend the best treatment.  Our investigations focus on therapies to prevent or manage complications of chronic kidney disease, the sustained loss of kidney function from any cause.

Our studies leverage data collected in clinical research studies and real-world data, health information reported and collected in real-world medical settings.  We have worked extensively with electronic health record data from the Veterans Health Administration, Medicare claims, and the United States Renal Data System, and have developed several collaborations with NIH funded trials and cohort studies in kidney disease.

Current Research Areas

Hypertension treatment

Areas of Interest

  • Blood pressure targets in CKD
  • Individualized prediction of treatment effects in CKD
  • Acute kidney injury after treatment intensification


Areas of Interest

  • Comparative effectiveness of dialysis vs medical management
  • Pragmatic trials in CKD
  • Dialysis decision support

Methods & Measurements

Areas of Interest

  • Causal inference
  • Heterogeneous treatment effects
  • Patient-centered outcomes of CKD treatment