MIPS member publications

MIPS researchers are highly prolific in driving innovations in biomarker discovery and state-of-the-art technologies for first-in-human clinical translation. These achievements are driven by a strong collaborative environment amongst members as well as the broader molecular imaging and theranostics research and clinical communities.

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Reviews (reverse chronological)

Original research (not yet sorted)

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Reviews (reverse chronological)

Bertozzi C. A Special Virtual Issue Celebrating the 2022 Nobel Prize in Chemistry for the Development of Click Chemistry and Bioorthogonal Chemistry. ACS Cent Sci. 2022 Dec 5;9(4):558-559. doi: 10.1021/acscentsci.2c01430. PMID: 37122475; PMCID: PMC10141613.

Pedersen C, Aboian M, Messina SA, Daldrup-Link H, Franceschi AM. PET/MRI Applications in Pediatric Epilepsy. World J Nucl Med. 2023 Apr 28;22(2):78-86. doi: 10.1055/s-0043-1764303. PMID: 37223623; PMCID: PMC10202574.

Iagaru A. 2022 SNMMI Highlights Lecture: General Nuclear Medicine. J Nucl Med. 2023 May;64(5):671-677. doi: 10.2967/jnumed.123.265758. Epub 2023 Apr 13. PMID: 37055218.

Küper A, Blanc-Durand P, Gafita A, Kersting D, Fendler WP, Seibold C, Moraitis A, Lückerath K, James ML, Seifert R. Is There a Role of Artificial Intelligence in Preclinical Imaging? Semin Nucl Med. 2023 Apr 8:S0001-2998(23)00027-2. doi: 10.1053/j.semnuclmed.2023.03.003. Epub ahead of print. PMID: 37037684.

Duan H, Iagaru A. Neuroendocrine Tumor Diagnosis: PET/MR Imaging. PET Clin. 2023 Apr;18(2):259-266. doi: 10.1016/j.cpet.2022.11.008. Epub 2023 Jan 25. PMID: 36707370.

Daldrup-Link HE. Pretherapy Ferumoxytol-enhanced MRI for Metastatic Breast Cancer: A New Approach for Predicting Tumor Delivery of Macromolecular Therapeutics? Radiol Imaging Cancer. 2023 Mar;5(2):e220183. doi: 10.1148/rycan.220183. PMID: 36734849.

Padwal J, Baratto L, Chakraborty A, Hawk K, Spunt S, Avedian R, Daldrup-Link HE. PET/MR of pediatric bone tumors: what the radiologist needs to know. Skeletal Radiol. 2023 Mar;52(3):315-328. doi: 10.1007/s00256-022-04113-6. Epub 2022 Jul 9. PMID: 35804163; PMCID: PMC9826799.

Shankar LK, Schöder H, Sharon E, Wolchok J, Knopp MV, Wahl RL, Ellingson BM, Hall NC, Yaffe MJ, Towbin AJ, Farwell MD, Pryma D, Poussaint TY, Wright CL, Schwartz L, Harisinghani M, Mahmood U, Wu AM, Leung D, de Vries EGE, Tang Y, Beach G, Reeves SA. Harnessing imaging tools to guide immunotherapy trials: summary from the National Cancer Institute Cancer Imaging Steering Committee workshop. Lancet Oncol. 2023 Mar;24(3):e133-e143. doi: 10.1016/S1470-2045(22)00742-2. PMID: 36858729.

Adams LC, Jayapal P, Ramasamy SK, Morakote W, Yeom K, Baratto L, Daldrup-Link HE. Ferumoxytol-Enhanced MRI in Children and Young Adults: State of the Art. AJR Am J Roentgenol. 2023 Feb 8:1-14. doi: 10.2214/AJR.22.28453. Epub ahead of print. PMID: 36197052.

Original research (not yet sorted)

Park EY, Cai X, Foiret J, Bendjador H, Hyun D, Fite BZ, Wodnicki R, Dahl JJ, Boutin RD, Ferrara KW. Fast volumetric ultrasound facilitates high-resolution 3D mapping of tissue compartments. Sci Adv. 2023 Jun 2;9(22):eadg8176. doi: 10.1126/sciadv.adg8176. Epub 2023 May 31. PMID: 37256942.

Ahmed R, Foiret J, Ferrara K, Trahey GE. Large-Array Deep Abdominal Imaging in Fundamental and Harmonic Mode. IEEE Trans Ultrason Ferroelectr Freq Control. 2023 May;70(5):406-421. doi: 10.1109/TUFFC.2023.3255800. Epub 2023 Apr 26. PMID: 37028314.

Dai T, Xie J, Buonomo JA, Moreno A, Banaei N, Bertozzi CR, Rao J. Bioluminogenic Probe for Rapid, Ultrasensitive Detection of β-Lactam-Resistant Bacteria. Anal Chem. 2023 May 9;95(18):7329-7335. doi: 10.1021/acs.analchem.3c00478. Epub 2023 Apr 21. PMID: 37083185; PMCID: PMC10175212.

Dong Q, Chang CM, Lee BJ, Sacco I, Sajedi S, Adams Z, Fischer P, Levin CS. The PETcoil project: PET performance evaluation of two detector modules for a second generation RF-penetrable TOF-PET brain dedicated insert for simultaneous PET/MRI. Phys Med Biol. 2023 Apr 5;68(8). doi: 10.1088/1361-6560/acc3f2. PMID: 36913739.

Dong Q, Adams Z, Watkins RD, Lee BJ, Chang CM, Sacco I, Levin CS. Study of compatibility between a 3T MR system and detector modules for a second-generation RF-penetrable TOF-PET insert for simultaneous PET/MRI. Med Phys. 2023 Mar 13. doi: 10.1002/mp.16354. Epub ahead of print. PMID: 36912373.

Song H, Guja KE, Yang EJ, Guo HH. 64Cu-DOTATATE Uptake in a Pulmonary Hamartoma. Clin Nucl Med. 2023 Jan 1;48(1):58-60. doi: 10.1097/RLU.0000000000004390. Epub 2022 Sep 6. PMID: 36469060.

Natarajan A, Khan S, Liang X, Nguyen H, Das N, Anders D, Malik N, Oderinde OM, Chin FT, Rosenthal E, Pratx G. Preclinical Evaluation of 89Zr-Panitumumab for Biology-Guided Radiation Therapy. Int J Radiat Oncol Biol Phys. 2023 Jan 18:S0360-3016(23)00056-1. doi: 10.1016/j.ijrobp.2023.01.007. Epub ahead of print. PMID: 36669541.

Reyes ST, Azevedo EC, Cropper HC, Nagy S, Deal EM, Chaney AM, James ML. Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography. J Vis Exp. 2023 Jan 20;(191). doi: 10.3791/64133. PMID: 36744792.

Jackson IM, Buccino PJ, Azevedo EC, Carlson ML, Luo ASZ, Deal EM, Kalita M, Reyes ST, Shao X, Beinat C, Nagy SC, Chaney AM, Anders DA, Scott PJH, Smith M, Shen B, James ML. Radiosynthesis and initial preclinical evaluation of [¹¹C]AZD1283 as a potential P2Y12R PET radiotracer. Nucl Med Biol. 2022 Nov-Dec;114-115:143-150. doi: 10.1016/j.nucmedbio.2022.05.001. Epub 2022 May 20. PMID: 35680502.

Levinstein MR, Carlton ML, Di Ianni T, Ventriglia EN, Rizzo A, Gomez JL, Budinich RC, Shaham Y, Airan RD, Zarate CA Jr, Bonaventura J, Michaelides M. Mu Opioid Receptor Activation Mediates (S)-ketamine Reinforcement in Rats: Implications for Abuse Liability. Biol Psychiatry. 2022 Dec 24:S0006-3223(22)01854-6. doi: 10.1016/j.biopsych.2022.12.019. Epub ahead of print. PMID: 36841701.

Thaler C, Tian Q, Wintermark M, Ghanouni P, Halpern CH, Henderson JM, Airan RD, Zeineh M, Goubran M, Leuze C, Fiehler J, Butts Pauly K, McNab JA. Changes in the Cerebello-Thalamo-Cortical Network After Magnetic Resonance-Guided Focused Ultrasound Thalamotomy. Brain Connect. 2023 Feb;13(1):28-38. doi: 10.1089/brain.2021.0157. Epub 2022 Jul 7. PMID: 35678063; PMCID: PMC9942176.

Baratto L, Nyalakonda R, Theruvath AJ, Sarrami AH, Hawk KE, Rashidi A, Shen S, States L, Aboian M, Jeng M, Daldrup-Link HE. Comparison of whole-body DW-MRI with 2-[¹⁸F]FDG PET for staging and treatment monitoring of children with Langerhans cell histiocytosis. Eur J Nucl Med Mol Imaging. 2023 Jan 31. doi: 10.1007/s00259-023-06122-6. Epub ahead of print. PMID: 36717409.

Wang YJ, Wang P, Adams LC, Sheybani ND, Qu L, Sarrami AH, Theruvath AJ, Gatidis S, Ho T, Zhou Q, Pribnow A, Thakor AS, Rubin D, Daldrup-Link HE. Low-count whole-body PET/MRI restoration: an evaluation of dose reduction spectrum and five state-of-the-art artificial intelligence models. Eur J Nucl Med Mol Imaging. 2023 Jan 12. doi: 10.1007/s00259-022-06097-w. Epub ahead of print. PMID: 36633614.

Wu WE, Chang E, Jin L, Liu S, Huang CH, Kamal R, Liang T, Aissaoui NM, Theruvath AJ, Pisani L, Moseley M, Stoyanova T, Paulmurugan R, Huang J, Mitchell DA, Daldrup-Link HE. Multimodal In Vivo Tracking of Chimeric Antigen Receptor T Cells in Preclinical Glioblastoma Models. Invest Radiol. 2022 Dec 22. doi: 10.1097/RLI.0000000000000946. Epub ahead of print. PMID: 36729074.

Zhao J, Van Vleck A, Winetraub Y, Du L, Han Y, Aasi S, Sarin KY, de la Zerda A. Rapid Cellular-Resolution Skin Imaging with Optical Coherence Tomography Using All-Glass Multifocal Metasurfaces. ACS Nano. 2023 Feb 28;17(4):3442-3451. doi: 10.1021/acsnano.2c09542. Epub 2023 Feb 6. PMID: 36745734.

Safir F, Vu N, Tadesse LF, Firouzi K, Banaei N, Jeffrey SS, Saleh AAE, Khuri-Yakub BPT, Dionne JA. Combining Acoustic Bioprinting with AI-Assisted Raman Spectroscopy for High-Throughput Identification of Bacteria in Blood. Nano Lett. 2023 Mar 1. doi: 10.1021/acs.nanolett.2c03015. Epub ahead of print. PMID: 36856600.

Dhanasekaran R, Hansen AS, Park J, Lemaitre L, Lai I, Adeniji N, Kuruvilla S, Suresh A, Zhang J, Swamy V, Felsher DW. MYC Overexpression Drives Immune Evasion in Hepatocellular Carcinoma That Is Reversible through Restoration of Proinflammatory Macrophages. Cancer Res. 2023 Feb 15;83(4):626-640. doi: 10.1158/0008-5472.CAN-22-0232. PMID: 36525476; PMCID: PMC9931653.

Yu JH, Jeong MS, Cruz EO, Alam IS, Tumbale SK, Zlitni A, Lee SY, Park YI, Ferrara K, Kwon SH, Gambhir SS, Rao J. Highly Excretable Gold Supraclusters for Translatable In Vivo Raman Imaging of Tumors. ACS Nano. 2023 Feb 14;17(3):2554-2567. doi: 10.1021/acsnano.2c10378. Epub 2023 Jan 23. PMID: 36688431.

Rafat M, El Kaffas A, Swarnakar A, Shostak A, Graves EE. Technical note: Noninvasive monitoring of normal tissue radiation damage using spectral quantitative ultrasound spectroscopy. Med Phys. 2023 Feb;50(2):1251-1256. doi: 10.1002/mp.16184. Epub 2023 Jan 8. PMID: 36564922; PMCID: PMC9940792.

Hu Z, Bieniosek M, Ferri V, Iagaru A, Kovalchuk N, Han B, Xing L, Vitzthum L, Olcott P, Narayanan M, Laurence T, Ren Y, Oderinde OM, Shirvani SM, Chang D, Surucu M. Image-mode performance characterisation of a positron emission tomography subsystem designed for Biology-guided radiotherapy (BgRT). Br J Radiol. 2023 Jan 1;96(1141):20220387. doi: 10.1259/bjr.20220387. Epub 2022 Nov 15. PMID: 36317922.

Duan H, Baratto L, Fan RE, Soerensen SJC, Liang T, Chung BI, Thong AEC, Gill H, Kunder C, Stoyanova T, Rusu M, Loening AM, Ghanouni P, Davidzon GA, Moradi F, Sonn GA, Iagaru A. Correlation of ⁶⁸Ga-RM2 PET with Postsurgery Histopathology Findings in Patients with Newly Diagnosed Intermediate- or High-Risk Prostate Cancer. J Nucl Med. 2022 Dec;63(12):1829-1835. doi: 10.2967/jnumed.122.263971. Epub 2022 May 12. PMID: 35552245.

Moradi F, Duan H, Song H, Davidzon GA, Chung BI, Thong AEC, Loening AM, Ghanouni P, Sonn G, Iagaru A. ⁶⁸Ga-PSMA-11 PET/MRI in Patients with Newly Diagnosed Intermediate- or High-Risk Prostate Adenocarcinoma: PET Findings Correlate with Outcomes After Definitive Treatment. J Nucl Med. 2022 Dec;63(12):1822-1828. doi: 10.2967/jnumed.122.263897. Epub 2022 May 5. PMID: 35512996.

Nakamoto R, Ferri V, Duan H, Hatami N, Goel M, Rosenberg J, Kimura R, Wardak M, Haywood T, Kellow R, Shen B, Park W, Iagaru A, Gambhir SS. Pilot-phase PET/CT study targeting integrin α_vβ₆ in pancreatic cancer patients using the cystine-knot peptide-based ¹⁸F-FP-R₀1-MG-F2. Eur J Nucl Med Mol Imaging. 2022 Dec;50(1):184-193. doi: 10.1007/s00259-021-05595-7. Epub 2021 Nov 3. PMID: 34729628.

Nazari-Farsani S, Yu Y, Duarte Armindo R, Lansberg M, Liebeskind DS, Albers G, Christensen S, Levin CS, Zaharchuk G. Predicting final ischemic stroke lesions from initial diffusion-weighted images using a deep neural network. Neuroimage Clin. 2022 Dec 1;37:103278. doi: 10.1016/j.nicl.2022.103278. Epub ahead of print. PMID: 36481696; PMCID: PMC9727698.

Afjei R, Sadeghipour N, Kumar SU, Pandrala M, Kumar V, Malhotra SV, Massoud TF, Paulmurugan R. A New Nrf2 Inhibitor Enhances Chemotherapeutic Effects in Glioblastoma Cells Carrying p53 Mutations. Cancers (Basel). 2022 Dec 12;14(24):6120. doi: 10.3390/cancers14246120. PMID: 36551609; PMCID: PMC9775980.

Khessib T, Franc B, Yang E, Moradi F. Retroperitoneal Inflammation Detected on FDG PET/CT in Patient on Long-Term Immunotherapy. Clin Nucl Med. 2023 Apr 1;48(4):e165-e166. doi: 10.1097/RLU.0000000000004513. Epub 2023 Feb 1. PMID: 36728374.

Schultz L, Davis KL, Walkush A, Baggott C, Erickson C, Ramakrishna S, Aftandilian C, Lacayo N, Nadel HR, Oak J, Mackall CL. Role of peripheral blood MRD and 18F-FDG PET in the post-CAR relapse setting: a case study of discordant peripheral blood and bone marrow MRD. J Immunother Cancer. 2023 Feb;11(2):e004851. doi: 10.1136/jitc-2022-004851. PMID: 36849202; PMCID: PMC9972424.

Zhang Y, Wang J, Ghobadi SN, Zhou H, Huang A, Gerosa M, Hou Q, Keunen O, Golebiewska A, Habte FG, Grant GA, Paulmurugan R, Lee KS, Wintermark M. Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Mouse Glioblastoma Model. Ultrasound Med Biol. 2023 Jan 28:S0301-5629(22)00666-4. doi: 10.1016/j.ultrasmedbio.2022.12.006. Epub ahead of print. PMID: 36717283.

Kim SB, Nishihara R, Paulmurugan R. Near-Infrared Imaging of Steroid Hormone Activities Using Bright BRET Templates. Int J Mol Sci. 2022 Dec 30;24(1):677. doi: 10.3390/ijms24010677. PMID: 36614119; PMCID: PMC9820568.

Basic Science Highlighted Article in JNM
Klein JS, Kim TJ, Pratx G. Development of a lensless radiomicroscope for cellular-resolution radionuclide imaging. J Nucl Med. 2023 Mar, 64 (3) 479-484; DOI: https://doi.org/10.2967/jnumed.122.264021

Yin Q, Luo W, Mallajosyula V, Bo Y, Guo J, Xie J, Sun M, Verma R, Li C, Constantz CM, Wagar LE, Li J, Sola E, Gupta N, Wang C, Kask O, Chen X, Yuan X, Wu NC, Rao J, Chien YH, Cheng J, Pulendran B, Davis MM. A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2. Nat Mater. 2023 Jan 30. doi: 10.1038/s41563-022-01464-2. Epub ahead of print. PMID: 36717665.

Early S, Saad MA, Mallidi S, Mansour A, Seist R, Hasan T, Stankovic KM. A fluorescent photoimmunoconjugate for imaging of cholesteatoma. Sci Rep. 2022 Nov 19;12(1):19905. doi: 10.1038/s41598-022-22072-9. PMID: 36402793; PMCID: PMC9675863.

Marić I, Contrepois K, Moufarrej MN, Stelzer IA, Feyaerts D, Han X, Tang A, Stanley N, Wong RJ, Traber GM, Ellenberger M, Chang AL, Fallahzadeh R, Nassar H, Becker M, Xenochristou M, Espinosa C, De Francesco D, Ghaemi MS, Costello EK, Culos A, Ling XB, Sylvester KG, Darmstadt GL, Winn VD, Shaw GM, Relman DA, Quake SR, Angst MS, Snyder MP, Stevenson DK, Gaudilliere B, Aghaeepour N. Early prediction and longitudinal modeling of preeclampsia from multiomics. Patterns (N Y). 2022 Dec 9;3(12):100655. doi: 10.1016/j.patter.2022.100655. PMID: 36569558; PMCID: PMC9768681.

Stevenson DK, Wong RJ, Nayak NR. Molecular Mechanisms of Pregnancy-Related Vascular Remodeling and Pregnancy Complications. Int J Mol Sci. 2023 Feb 13;24(4):3712. doi: 10.3390/ijms24043712. PMID: 36835124; PMCID: PMC9965456.

Ganguly A, Swaminathan G, Garcia-Marques F, Regmi S, Yarani R, Primavera R, Chetty S, Bermudez A, Pitteri SJ, Thakor AS. Integrated transcriptome-proteome analyses of human stem cells reveal source-dependent differences in their regenerative signature. Stem Cell Reports. 2023 Jan 10;18(1):190-204. doi: 10.1016/j.stemcr.2022.11.006. Epub 2022 Dec 8. PMID: 36493779; PMCID: PMC9860079.

Islam MT, Xing L. Cartography of Genomic Interactions Enables Deep Analysis of Single-Cell Expression Data. Nat Commun. 2023 Feb 8;14(1):679. doi: 10.1038/s41467-023-36383-6. PMID: 36755047; PMCID: PMC9908983.

Eminaga O, Abbas M, Shen J, Laurie M, Brooks JD, Liao JC, Rubin DL. PlexusNet: A neural network architectural concept for medical image classification. Comput Biol Med. 2023 Mar;154:106594. doi: 10.1016/j.compbiomed.2023.106594. Epub 2023 Jan 26. PMID: 36753979.

Riley NM, Wen RM, Bertozzi CR, Brooks JD, Pitteri SJ. Measuring the multifaceted roles of mucin-domain glycoproteins in cancer. Adv Cancer Res. 2023;157:83-121. doi: 10.1016/bs.acr.2022.09.001. Epub 2022 Oct 8. PMID: 36725114.

Su Y, Walker JR, Hall MP, Klein MA, Wu X, Encell LP, Casey KM, Liu LX, Hong G, Lin MZ, Kirkland TA. An optimized bioluminescent substrate for non-invasive imaging in the brain. Nat Chem Biol. 2023 Feb 9. doi: 10.1038/s41589-023-01265-x. Epub ahead of print. PMID: 36759751.

Wong JYC, Yamauchi DM, Adhikarla V, Simpson J, Frankel PH, Fong Y, Melstrom KA, Chen YJ, Salehian BD, Woo Y, Dandapani SV, Colcher DM, Poku EK, Yazaki PJ, Wu AM, Shively JE. First-In-Human Pilot PET Immunoimaging Study of ⁶⁴Cu-Anti-Carcinoembryonic Antigen Monoclonal Antibody (hT84.66-M5A) in Patients with Carcinoembryonic Antigen-Producing Cancers. Cancer Biother Radiopharm. 2023 Feb;38(1):26-37. doi: 10.1089/cbr.2022.0028. Epub 2022 Sep 26. PMID: 36154291.

Oh J, Gutkin P, Wang YP, Sandhu N, Majzner RG, Nadel H, Shimada H, Lansinger O, von Eyben R, Donaldson S, Bruzoni M, Sodji QH, Hiniker SM. Time to resolution of iodine-123 metaiodobenzylguanidine (¹²³ I-MIBG) avidity and local control outcomes for high-risk neuroblastoma following radiation therapy. J Med Imaging Radiat Oncol. 2023 Feb;67(1):81-88. doi: 10.1111/1754-9485.13487. Epub 2022 Oct 27. PMID: 36300562.

Reviews (reverse chronological)

De la Zerda A Wang SX. Biochips and Medical Imaging. First ed. Hoboken NJ USA: John Wiley & Sons; 2022.

Gonzalez-Montoro A, Ullah MN, Levin CS. Advances in Detector Instrumentation for PET. J Nucl Med. 2022 Aug;63(8):1138-1144. doi: 10.2967/jnumed.121.262509. PMID: 35914819; PMCID: PMC9364348.

Song H, Iagaru A, Rowe SP. 18F-DCFPyL PET Acquisition, Interpretation, and Reporting: Suggestions After Food and Drug Administration Approval. J Nucl Med. 2022 Jun;63(6):855-859. doi: 10.2967/jnumed.121.262989. Epub 2021 Sep 16. PMID: 34531266.

Song H, Guja KE, Iagaru A. PSMA theragnostics for metastatic castration resistant prostate cancer. Transl Oncol. 2022 Aug;22:101438. doi: 10.1016/j.tranon.2022.101438. Epub 2022 May 31. PMID: 35659674; PMCID: PMC9163091.

Pedersen C, Aboian M, McConathy JE, Daldrup-Link H, Franceschi AM. PET/MRI in Pediatric Neuroimaging: Primer for Clinical Practice. AJNR Am J Neuroradiol. 2022 May 5. doi: 10.3174/ajnr.A7464. Epub ahead of print. PMID: 35512826.

Fruhwirth, G.O., Weigelin, B., Daldrup-Link, H.E. Ponomarev, V. Editorial to the Special Issue Entitled “Imaging in Immunooncology”. Mol Imaging Biol (2022). https://doi.org/10.1007/s11307-022-01719-z

Zhao MY, Woodward A, Fan AP, Chen KT, Yu Y, Chen DY, Moseley ME, Zaharchuk G. Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniques. J Cereb Blood Flow Metab. 2022 May;42(5):700-717. doi: 10.1177/0271678X211056702. Epub 2021 Nov 22. PMID: 34806918.

Muir RK, Guerra M, Bogyo MM. Activity-Based Diagnostics: Recent Advances in the Development of Probes for Use with Diverse Detection Modalities. ACS Chem Biol. 2022 Feb 18;17(2):281-291. doi: 10.1021/acschembio.1c00753. Epub 2022 Jan 13. PMID: 35026106.

Daldrup-Link HE, Theruvath AJ, Rashidi A, Iv M, Majzner RG, Spunt SL, Goodman S, Moseley M. How to stop using gadolinium chelates for magnetic resonance imaging: clinical-translational experiences with ferumoxytol. Pediatr Radiol. 2022 Feb;52(2):354-366. doi: 10.1007/s00247-021-05098-5. Epub 2021 May 27. PMID: 34046709; PMCID: PMC8626538.

Nishiga M, Liu C, Qi LS, Wu JC. The use of new CRISPR tools in cardiovascular research and medicine. Nat Rev Cardiol. 2022 Feb 10. doi: 10.1038/s41569-021-00669-3. Epub ahead of print. PMID: 35145236.

Kim TH, Schnitzer MJ. Fluorescence imaging of large-scale neural ensemble dynamics. Cell. 2022 Jan 6;185(1):9-41. doi: 10.1016/j.cell.2021.12.007. PMID: 34995519; PMCID: PMC8849612.

Duan H, Iagaru A, Aparici CM. Radiotheranostics - Precision Medicine in Nuclear Medicine and Molecular Imaging. Nanotheranostics. 2022 Jan 1;6(1):103-117. doi: 10.7150/ntno.64141. PMID: 34976584; PMCID: PMC8671964.

Ullah MN, Levin CS. Application of Artificial Intelligence in PET Instrumentation. PET Clin. 2022 Jan;17(1):175-182. doi: 10.1016/j.cpet.2021.09.011. PMID: 34809865.

Windows-Yule CRK, Herald MT, Nicuşan AL, Wiggins CS, Pratx G, Manger S, Odo AE, Leadbeater T, Pellico J, de Rosales RTM, Renaud A, Govender I, Carasik LB, Ruggles AE, Kokalova-Wheldon T, Seville JPK, Parker DJ. Recent advances in positron emission particle tracking: a comparative review. Rep Prog Phys. 2022 Jan 7;85(1). doi: 10.1088/1361-6633/ac3c4c. PMID: 34814127.

Li C, Han C, Duan S, Li P, Alam I, Xiao Z. Visualizing T cell responses: The T cell PET imaging toolbox. J Nucl Med. 2021 Dec 9:jnumed.121.261976. doi: 10.2967/jnumed.121.261976. Epub ahead of print. PMID: 34887338.

Thangam R, Paulmurugan R, Kang H. Functionalized Nanomaterials as Tailored Theranostic Agents in Brain Imaging. Nanomaterials (Basel). 2021 Dec 22;12(1):18. doi: 10.3390/nano12010018. PMID: 35009968; PMCID: PMC8746658.

Original research (reverse chronological)

Duan H, Baratto L, Fan RE, Soerensen SJC, Liang T, Chung BI, Thong AEC, Gill H, Kunder C, Stoyanova T, Rusu M, Loening AM, Ghanouni P, Davidzon GA, Moradi F, Sonn GA, Iagaru A. Correlation of 68Ga-RM2 PET with Postsurgery Histopathology Findings in Patients with Newly Diagnosed Intermediate- or High-Risk Prostate Cancer. J Nucl Med. 2022 Dec;63(12):1829-1835. doi: 10.2967/jnumed.122.263971. Epub 2022 May 12. PMID: 35552245.

Ganguly A, Swaminathan G, Garcia-Marques F, Regmi S, Yarani R, Primavera R, Chetty S, Bermudez A, Pitteri SJ, Thakor AS. Integrated transcriptome-proteome analyses of human stem cells reveal source-dependent differences in their regenerative signature. Stem Cell Reports. 2022 Dec 2:S2213-6711(22)00539-2. doi: 10.1016/j.stemcr.2022.11.006. Epub ahead of print. PMID: 36493779.

Moradi F, Duan H, Song H, Davidzon GA, Chung BI, Thong AEC, Loening AM, Ghanouni P, Sonn G, Iagaru A. 68Ga-PSMA-11 PET/MRI in Patients with Newly Diagnosed Intermediate- or High-Risk Prostate Adenocarcinoma: PET Findings Correlate with Outcomes After Definitive Treatment. J Nucl Med. 2022 Dec;63(12):1822-1828. doi: 10.2967/jnumed.122.263897. Epub 2022 May 5. PMID: 35512996.

Wang J, Fite BZ, Kare AJ, Wu B, Raie M, Tumbale SK, Zhang N, Davis RR, Tepper CG, Aviran S, Newman AM, King DA, Ferrara KW. Multiomic analysis for optimization of combined focal and immunotherapy protocols in murine pancreatic cancer. Theranostics. 2022 Nov 14;12(18):7884-7902. doi: 10.7150/thno.73218. PMID: 36451859; PMCID: PMC9706583.

Rashidi A, Baratto L, Jayapal P, Theruvath AJ, Greene EB, Lu R, Spunt SL, Daldrup-Link HE. Detection of bone marrow metastases in children and young adults with solid cancers with diffusion-weighted MRI. Skeletal Radiol. 2022 Nov 28. doi: 10.1007/s00256-022-04240-0. Epub ahead of print. PMID: 36441237.

Wang J, Chang J, Liu Y, Bennett DL, Poplack SP. A comparison of the imaging appearance of breast cancer in African American women with non-Latina white women. Clin Imaging. 2023 Jan;93:75-82. doi: 10.1016/j.clinimag.2022.11.004. Epub 2022 Nov 17. PMID: 36413877.

Tu C, Liu Y, Williams DR, Wu JC. A transcriptomic atlas of drug-induced endothelial dysfunction in human endothelial cells. J Mol Cell Cardiol. 2022 Dec;173:115-117. doi: 10.1016/j.yjmcc.2022.10.002. Epub 2022 Oct 27. PMID: 36327770.

Ha B, Liang K, Liu C, Melemenidis S, Manjappa R, Viswanathan V, Das N, Ashraf R, Lau B, Soto L, Graves EE, Rao J, Loo BW Jr, Pratx G. Real-time optical oximetry during FLASH radiotherapy using a phosphorescent nanoprobe. Radiother Oncol. 2022 Nov;176:239-243. doi: 10.1016/j.radonc.2022.08.011. Epub 2022 Aug 11. PMID: 35964762.

Chen IY, Olshausen J, Thomas D, Lai C, McLaughlin TL, Wu JC. Generation of three induced pluripotent stem cell lines to model and investigate diseases affecting Hispanics. Stem Cell Res. 2022 Dec;65:102969. doi: 10.1016/j.scr.2022.102969. Epub 2022 Nov 14. PMID: 36427473.

Zhao MY, Armindo RD, Gauden AJ, Yim B, Tong E, Moseley M, Steinberg GK, Zaharchuk G. Revascularization improves vascular hemodynamics - a study assessing cerebrovascular reserve and transit time in Moyamoya patients using MRI. J Cereb Blood Flow Metab. 2022 Nov 20:271678X221140343. doi: 10.1177/0271678X221140343. Epub ahead of print. PMID: 36408536.

Wang YJ, Zhang X, Lam CK, Guo H, Wang C, Zhang S, Wu JC, Snyder M, Li J. Systems analysis of de novo mutations in congenital heart diseases identified a protein network in the hypoplastic left heart syndrome. Cell Syst. 2022 Nov 16;13(11):895-910.e4. doi: 10.1016/j.cels.2022.09.001. Epub 2022 Sep 26. PMID: 36167075; PMCID: PMC9671831.

Mohammadjavadi M, Ash RT, Li N, Gaur P, Kubanek J, Saenz Y, Glover GH, Popelka GR, Norcia AM, Pauly KB. Transcranial ultrasound neuromodulation of the thalamic visual pathway in a large animal model and the dose-response relationship with MR-ARFI. Sci Rep. 2022 Nov 15;12(1):19588. doi: 10.1038/s41598-022-20554-4. PMID: 36379960; PMCID: PMC9666449.

Jain MS, Telischak NA, Heit JJ, Do HM, Massoud TF. Comparison of embolization strategies for mixed plexiform and fistulous brain arteriovenous malformations: a computational model analysis of theoretical risks of nidus rupture. J Neurointerv Surg. 2022 Dec;14(12):1213-1219. doi: 10.1136/neurintsurg-2021-018067. Epub 2021 Dec 10. PMID: 34893533.

Nakamoto R, Ferri V, Duan H, Hatami N, Goel M, Rosenberg J, Kimura R, Wardak M, Haywood T, Kellow R, Shen B, Park W, Iagaru A, Gambhir SS. Pilot-phase PET/CT study targeting integrin αvβ6 in pancreatic cancer patients using the cystine-knot peptide-based 18F-FP-R01-MG-F2. Eur J Nucl Med Mol Imaging. 2022 Dec;50(1):184-193. doi: 10.1007/s00259-021-05595-7. Epub 2021 Nov 3. PMID: 34729628.

Ha B, Liang K, Liu C, Melemenidis S, Manjappa R, Viswanathan V, Das N, Ashraf R, Lau B, Soto L, Graves EE, Rao J, Loo BW Jr, Pratx G. Real-time optical oximetry during FLASH radiotherapy using a phosphorescent nanoprobe. Radiother Oncol. 2022 Aug 11:S0167-8140(22)04232-3. doi: 10.1016/j.radonc.2022.08.011. Epub ahead of print. PMID: 35964762.

Seo JW, Ajenjo J, Wu B, Robinson E, Raie MN, Wang J, Tumbale SK, Buccino P, Anders DA, Shen B, Habte FG, Beinat C, James ML, Reyes ST, Ravindra Kumar S, Miles TF, Lee JT, Gradinaru V, Ferrara KW. Multimodal imaging of capsid and cargo reveals differential brain targeting and liver detargeting of systemically-administered AAVs. Biomaterials. 2022 Aug 6:121701. doi: 10.1016/j.biomaterials.2022.121701. Epub ahead of print. PMID: 35985893.

Lee YJ, van den Berg NS, Duan H, Azevedo EC, Ferri V, Hom M, Raymundo RC, Valencia A, Castillo J, Shen B, Zhou Q, Freeman L, Koran ME, Kaplan MJ, Colevas AD, Baik FM, Chin FT, Martin BA, Iagaru A, Rosenthal EL. 89Zr-panitumumab combined with 18F-FDG-PET improves detection and staging of head and neck squamous cell carcinoma. Clin Cancer Res. 2022 Aug 5:CCR-22-0094. doi: 10.1158/1078-0432.CCR-22-0094. Epub ahead of print. PMID: 35929985.

Foiret J, Cai X, Bendjador H, Park EY, Kamaya A, Ferrara KW. Improving plane wave ultrasound imaging through real-time beamformation across multiple arrays. Sci Rep. 2022 Aug 4;12(1):13386. doi: 10.1038/s41598-022-16961-2. PMID: 35927389; PMCID: PMC9352764.

Lautman Z, Winetraub Y, Blacher E, Yu C, Terem I, Chibukhchyan A, Marshel JH, de la Zerda A. Intravital 3D visualization and segmentation of murine neural networks at micron resolution. Sci Rep. 2022 Jul 30;12(1):13130. doi: 10.1038/s41598-022-14450-0. PMID: 35907928; PMCID: PMC9338956.

Xiao Z, Alam IS, Simonetta F, Chen W, Scheller L, Murty S, Lohmeyer JK, Lopes Ramos TL, James ML, Negrin RS, Gambhir SS. ICOS ImmunoPET Enables Visualization of Activated T Cells and Early Diagnosis of Murine Acute Gastrointestinal GvHD. Blood Adv. 2022 Jul 5:bloodadvances.2022007403. doi: 10.1182/bloodadvances.2022007403. Epub ahead of print. PMID: 35790103.

Rashidi A, Theruvath AJ, Huang CH, Wu W, Mahmoud EE, Jesu Raj JG, Marycz K, Daldrup-Link HE. Vascular injury of immature epiphyses impair stem cell engraftment in cartilage defects. Sci Rep. 2022 Jul 9;12(1):11696. doi: 10.1038/s41598-022-15721-6. PMID: 35810189; PMCID: PMC9271080.

Padwal J, Baratto L, Chakraborty A, Hawk K, Spunt S, Avedian R, Daldrup-Link HE. PET/MR of pediatric bone tumors: what the radiologist needs to know. Skeletal Radiol. 2022 Jul 9. doi: 10.1007/s00256-022-04113-6. Epub ahead of print. PMID: 35804163.

Rashidi A, Baratto L, Theruvath AJ, Greene EB, Hawk KE, Lu R, Link MP, Spunt SL, Daldrup-Link HE. Diagnostic Accuracy of 2-[18F]FDG-PET and whole-body DW-MRI for the detection of bone marrow metastases in children and young adults. Eur Radiol. 2022 Jul;32(7):4967-4979. doi: 10.1007/s00330-021-08529-x. Epub 2022 Jan 31. PMID: 35099603; PMCID: PMC9232918.

Bendjador H, Foiret J, Wodnicki R, Stephens DN, Krut Z, Park EY, Gazit Z, Gazit D, Pelled G, Ferrara KW. A theranostic 3D ultrasound imaging system for high resolution image-guided therapy. Theranostics. 2022 Jun 27;12(11):4949-4964. doi: 10.7150/thno.71221. PMID: 35836805; PMCID: PMC9274734.

Jackson IM, Webb EW, Scott PJH, James ML. In Silico Approaches for Addressing Challenges in CNS Radiopharmaceutical Design. ACS Chem Neurosci. 2022 Jun 15;13(12):1675-1683. doi: 10.1021/acschemneuro.2c00269. Epub 2022 May 23. PMID: 35606334.

Duan H, Ferri V, Fisher GA, Shaheen S, Davidzon GA, Iagaru A, Mari Aparici C. Evaluation of Liver and Renal Toxicity in Peptide Receptor Radionuclide Therapy for Somatostatin Receptor Expressing Tumors: A 2-Year Follow-Up. Oncologist. 2022 Jun 8;27(6):447-452. doi: 10.1093/oncolo/oyab072. PMID: 35641196; PMCID: PMC9177120.

Pal R, Hom ME, van den Berg NS, Lwin TM, Lee YJ, Prilutskiy A, Faquin W, Yang E, Saladi SV, Varvares MA, Rosenthal EL, Kumar ATN. First Clinical Results of Fluorescence Lifetime-enhanced Tumor Imaging Using Receptor-targeted Fluorescent Probes. Clin Cancer Res. 2022 Jun 1;28(11):2373-2384. doi: 10.1158/1078-0432.CCR-21-3429. PMID: 35302604; PMCID: PMC9167767.

Pemmaraju R, Minahan R, Wang E, Schadl K, Daldrup-Link H, Habte F. Web-Based Application for Biomedical Image Registry, Analysis, and Translation (BiRAT). Tomography. 2022 May 30;8(3):1453-1462. doi: 10.3390/tomography8030117. PMID: 35736865; PMCID: PMC9228304.

Jackson IM, Buccino PJ, Azevedo EC, Carlson ML, Luo ASZ, Deal EM, Kalita M, Reyes ST, Shao X, Beinat C, Nagy SC, Chaney AM, Anders DA, Scott PJH, Smith M, Shen B, James ML. Radiosynthesis and initial preclinical evaluation of [11C]AZD1283 as a potential P2Y12R PET radiotracer. Nucl Med Biol. 2022 May 20:S0969-8051(22)00049-X. doi: 10.1016/j.nucmedbio.2022.05.001. Epub ahead of print. PMID: 35680502.

Xie J, El Rami F, Zhou K, Simonetta F, Chen Z, Zheng X, Chen M, Balakrishnan PB, Dai SY, Murty S, Alam IS, Baker J, Negrin RS, Gambhir SS, Rao J. Multiparameter Longitudinal Imaging of Immune Cell Activity in Chimeric Antigen Receptor T Cell and Checkpoint Blockade Therapies. ACS Cent Sci [Internet]. American Chemical Society; 2022 May 12

Duan H, Baratto L, Fan RE, Soerensen SJC, Liang T, Chung BI, Thong AEC, Gill H, Kunder C, Stoyanova T, Rusu M, Loening AM, Ghanouni P, Davidzon GA, Moradi F, Sonn GA, Iagaru A. Correlation of ⁶⁸Ga-RM2 PET with Post-Surgery Histopathology Findings in Patients with Newly Diagnosed Intermediate- or High-Risk Prostate Cancer. J Nucl Med. 2022 May 1;jnumed.122.263971.

Farshad Moradi, Heying Duan, Hong Song, Guido A Davidzon, Benjamin I Chung, Alan E C Thong, Andreas M Loening, Pejman Ghanouni, Geoffrey Sonn and Andrei Iagaru. 68Ga-PSMA-11 PET/MRI in patients with newly diagnosed intermediate or high-risk prostate adenocarcinoma: PET findings correlate with outcomes after definitive treatment. Journal of Nuclear Medicine. May 2022, jnumed.122.263897; DOI: https://doi.org/10.2967/jnumed.122.263897

Jiang Y, Zhang Z, Yuan Q, Wang W, Wang H, Li T, Huang W, Xie J, Chen C, Sun Z, Yu J, Xu Y, Poultsides GA, Xing L, Zhou Z, Li G, Li R. Predicting peritoneal recurrence and disease-free survival from CT images in gastric cancer with multitask deep learning: a retrospective study. Lancet Digit Health. 2022 May;4(5):e340-e350. doi: 10.1016/S2589-7500(22)00040-1. PMID: 35461691.

Zhang M, Zhou Q, Huang C, Chan CT, Wu W, Li G, Lim M, Gambhir SS, Daldrup-Link HE. In Vivo Evaluation of Near-Infrared Fluorescent Probe for TIM3 Targeting in Mouse Glioma. Mol Imaging Biol. 2022 Apr;24(2):280-287. doi: 10.1007/s11307-021-01667-0. Epub 2021 Nov 30. PMID: 34846678; PMCID: PMC9254586.

Bose et al. Engineered Cell-Derived Vesicles Displaying Targeting Peptide and Functionalized with Nanocarriers for Therapeutic microRNA Delivery to Triple-Negative Breast Cancer in Mice. Adv Healthc Mater. 2022.

Chen et al. Alternative medicine: therapeutic effects on gastric original signet ring carcinoma via ascorbate and combination with sodium alpha lipoate. BMC Complement Med Ther. 2022.

Cui et al. 3D computational model of oxygen depletion kinetics in brain vasculature during FLASH RT and its implications for in vivo oximetry experiments. Med Phys. 2022.

Duan et al. Reduced Acquisition Time per Bed Position for PET/MRI Using 68Ga-RM2 or 68Ga-PSMA-11 in Patients With Prostate Cancer: A Retrospective Analysis. AJR Am J Roentgenol. 2022.

Eke et al. Long-term expression changes of immune-related genes in prostate cancer after radiotherapy. Cancer Immunol Immunother. 2022.

Hu et al. Detection and Characterization of Sentinel Lymph Node by Ultrasound Molecular Imaging with B7-H3-Targeted Microbubbles in Orthotopic Breast Cancer Model in Mice. Mol Imaging Biol. 2022.

Kim et al. A red fluorescent protein with improved monomericity enables ratiometric voltage imaging with ASAP3. Sci Rep. 2022.

Lecler et al. Comparison between 7 Tesla and 3 Tesla MRI for characterizing orbital lesions. Diagn Interv Imaging. 2022.

Liu et al. Reversibly Photoswitching Upconversion Nanoparticles for Super-Sensitive Photoacoustic Molecular Imaging. Angew Chem Int Ed Engl. 2022.

Shen et al. Novel-view X-ray projection synthesis through geometry-integrated deep learning. Med Image Anal. 2022.

Zhao et al. Using arterial spin labeling to measure cerebrovascular reactivity in Moyamoya disease: Insights from simultaneous PET/MRI. J Cereb Blood Flow Metab. 2022.

Kim Y, Jung HJ, Lee Y, Koo S, Thangam R, Jang WY, Kim SY, Park S, Lee S, Bae G, Patel KD, Wei Q, Lee KB, Paulmurugan R, Jeong WK, Hyeon T, Kim D, Kang H. Manipulating Nanoparticle Aggregates Regulates Receptor-Ligand Binding in Macrophages. J Am Chem Soc. 2022 Apr 6;144(13):5769-5783. doi: 10.1021/jacs.1c08861. Epub 2022 Mar 11. PMID: 35275625.

Gao H, Liu J, Lin Y, Gan GN, Pratx G, Wang F, Langen K, Bradley JD, Rotondo RL, Li HH, Chen RC. Simultaneous dose and dose rate optimization (SDDRO) of the FLASH effect for pencil-beam-scanning proton therapy. Med Phys. 2022 Mar;49(3):2014-2025. doi: 10.1002/mp.15356. Epub 2021 Dec 7. PMID: 34800301; PMCID: PMC8917068.

Alongi P, Laudicella R, Lanzafame H, Farolfi A, Mapelli P, Picchio M, Burger IA, Iagaru A, Minutoli F, Evangelista L. PSMA and Choline PET for the Assessment of Response to Therapy and Survival Outcomes in Prostate Cancer Patients: A Systematic Review from the Literature. Cancers (Basel). 2022 Mar 31;14(7):1770. doi: 10.3390/cancers14071770. PMID: 35406542; PMCID: PMC8997431.

Quan Zhou, Nynke S. van den Berg, Wenying Kang, Jacqueline Pei, Naoki Nishio, Stan van Keulen, Myrthe A. Engelen, Yu-Jin Lee, Marisa Hom, Johana C. M. Vega Leonel, Zachary Hart, Hannes Vogel, Romain Cayrol, Brock A. Martin, Mark Roesner, Glenn Shields, Natalie Lui, Melanie Hayden Gephart, Roan C. Raymundo, Grace Yi, Monica Granucci, Gerald A. Grant, Gordon Li and Eben L. Rosenthal. Factors for differential outcome across cancers in clinical molecular-targeted fluorescence imaging. J Nucl Med 2022 Published March 24, 2022 as doi:10.2967/jnumed.121.263674

Turco S, Tiyarattanachai T, Ebrahimkheil K, Eisenbrey J, Kamaya A, Mischi M, Lyshchik A, El Kaffas A. Interpretable machine learning for characterization of focal liver lesions by contrast-enhanced ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 Mar 23;PP. doi: 10.1109/TUFFC.2022.3161719. Epub ahead of print. PMID: 35320099.

Zhao MY, Fan AP, Chen DY, Ishii Y, Khalighi MM, Moseley M, Steinberg GK, Zaharchuk G. Using arterial spin labeling to measure cerebrovascular reactivity in Moyamoya disease: Insights from simultaneous PET/MRI. J Cereb Blood Flow Metab. 2022 Mar 2:271678X221083471. doi: 10.1177/0271678X221083471. Epub ahead of print. PMID: 35236136.

Minamimoto R, Baratto L, Iagaru A. Association Between Time Since Administration of Pegylated G-CSF (Pegfilgrastim) and Bone Marrow Uptake on FDG PET/CT: Determination of a Minimum Interval. AJR Am J Roentgenol. 2022 Feb;218(2):351-358. doi: 10.2214/AJR.21.26480. Epub 2021 Sep 1. PMID: 34467784.

Filipiak P, Shepherd T, Lin YC, Placantonakis DG, Boada FE, Baete SH. Performance of orientation distribution function-fingerprinting with a biophysical multicompartment diffusion model. Magn Reson Med. 2022 Feb 28. doi: 10.1002/mrm.29208. Epub ahead of print. PMID: 35225365.

Wardak M, Sonni I, Fan AP, Minamimoto R, Jamali M, Hatami N, Zaharchuk G, Fischbein N, Nagpal S, Li G, Koglin N, Berndt M, Bullich S, Stephens AW, Dinkelborg LM, Abel T, Manning HC, Rosenberg J, Chin FT, Sam Gambhir S, Mittra ES. 18F-FSPG PET/CT Imaging of System xC- Transporter Activity in Patients with Primary and Metastatic Brain Tumors. Radiology. 2022 Feb 22:203296. doi: 10.1148/radiol.203296. Epub ahead of print. PMID: 35191738.

McLellan CA, Siefe C, Casar JR, Peng CS, Fischer S, Lay A, Parakh A, Ke F, Gu XW, Mao W, Chu S, Goodman MB, Dionne JA. Engineering Bright and Mechanosensitive Alkaline-Earth Rare-Earth Upconverting Nanoparticles. J Phys Chem Lett. 2022 Feb 17;13(6):1547-1553. doi: 10.1021/acs.jpclett.1c03841. Epub 2022 Feb 8. PMID: 35133831.

Ravi N, Chang SE, Franco LM, Nagamani SCS, Khatri P, Utz PJ, Wang SX. A GMR-based assay for quantification of the human response to influenza. Biosens Bioelectron. 2022 Feb 17;205:114086. doi: 10.1016/j.bios.2022.114086. Epub ahead of print. PMID: 35192997.

Lucot KL, Stevens MY, Bonham TA, Azevedo EC, Chaney AM, Webber ED, Jain P, Klockow JL, Jackson IM, Carlson ML, Graves EE, Montine TJ, James ML. Tracking innate immune activation in a mouse model of Parkinson's disease using TREM1 and TSPO PET tracers. J Nucl Med. 2022 Feb 17:jnumed.121.263039. doi: 10.2967/jnumed.121.263039. Epub ahead of print. PMID: 35177426.

Cover Article
Goreke U, Bode A, Yaman S, Gurkan UA, Durmus NG. Size and density measurements of single sickle red blood cells using microfluidic magnetic levitation. Lab Chip. 2022 Feb 15;22(4):683-696. doi: 10.1039/d1lc00686j. PMID: 35094036.

Liu C, Zheng X, Dai T, Wang H, Chen X, Chen B, Sun T, Wang F, Chu S, Rao J. Reversibly Photoswitching Upconversion Nanoparticles for Super-Sensitive Photoacoustic Molecular Imaging. Angew Chem Int Ed Engl. 2022 Feb 9:e202116802. doi: 10.1002/anie.202116802. Epub ahead of print. PMID: 35139242.

Sodji QH, Harris JP, Quon A, Modlin LA, Lau B, Jiang A, Trakul N, Maxim PG, Diehn M, Loo BW Jr, Hiniker SM. Detection of Recurrence After Thoracic Stereotactic Ablative Radiotherapy Using FDG-PET-CT. Clin Lung Cancer. 2022 Feb 4:S1525-7304(22)00010-9. doi: 10.1016/j.cllc.2022.01.006. Epub ahead of print. PMID: 35246393.

Di Ianni T, Airan RD. Deep-fUS: A deep learning platform for functional ultrasound imaging of the brain using sparse data. IEEE Trans Med Imaging. 2022 Feb 2;PP. doi: 10.1109/TMI.2022.3148728. Epub ahead of print. PMID: 35108201.

Louise Kiru, Aimen Zlitni, Aidan Michael Tousley, Guillermo Nicolás Dalton, Wei Wu, Famyrah Lafortune, Anna Liu, Kristen May Cunanan, Hossein Nejadnik, Todd Sulchek, Michael Eugene Moseley, Robbie G. Majzner, Heike Elisabeth Daldrup-Link. In vivo imaging of nanoparticle-labeled CAR T cells. PNAS. Feb 2022, 119 (6) e2102363119; DOI: 10.1073/pnas.2102363119
Paper discussed in "Diving into Imaging Science" ESMI podcast

Jung KO, Theruvath AJ, Nejadnik H, Liu A, Xing L, Sulchek T, Daldrup-Link HE, Pratx G. Mechanoporation enables rapid and efficient radiolabeling of stem cells for PET imaging. Sci Rep. 2022 Feb 22;12(1):2955. doi: 10.1038/s41598-022-06938-6. PMID: 35194089; PMCID: PMC8863797.

Yoon D, Xu Y, Cipriano PW, Alam IS, Mari Aparici C, Tawfik VL, Curtin CM, Carroll IR, Biswal S. Neurovascular, Muscle, and Skin Changes on [18F]FDG PET/MRI in Complex Regional Pain Syndrome of the Foot: A Prospective Clinical Study. Pain Med. 2022 Feb 1;23(2):339-346. doi: 10.1093/pm/pnab315. PMID: 34718774; PMCID: PMC8807071.

Rashidi A, Baratto L, Theruvath AJ, Greene EB, Hawk KE, Lu R, Link MP, Spunt SL, Daldrup-Link HE. Diagnostic Accuracy of 2-[18F]FDG-PET and whole-body DW-MRI for the detection of bone marrow metastases in children and young adults. Eur Radiol. 2022 Jan 31. doi: 10.1007/s00330-021-08529-x. Epub ahead of print. PMID: 35099603.

Wang H, Vilches-Moure JG, Bettinger T, Cherkaoui S, Lutz A, Paulmurugan R. Contrast Enhanced Ultrasound Molecular Imaging of Spontaneous Chronic Inflammatory Bowel Disease in an Interleukin-2 Receptor α-/- Transgenic Mouse Model Using Targeted Microbubbles. Nanomaterials (Basel). 2022 Jan 17;12(2):280. doi: 10.3390/nano12020280. PMID: 35055297; PMCID: PMC8779209.

Lee CK, Atibalentja DF, Yao LE, Park J, Kuruvilla S, Felsher DW. Anti-PD-L1 F(ab) Conjugated PEG-PLGA Nanoparticle Enhances Immune Checkpoint Therapy. Nanotheranostics. 2022 Jan 16;6(3):243-255. doi: 10.7150/ntno.65544. PMID: 35145835; PMCID: PMC8824669.

Theruvath J, Menard M, Smith BAH, Linde MH, Coles GL, Dalton GN, Wu W, Kiru L, Delaidelli A, Sotillo E, Silberstein JL, Geraghty AC, Banuelos A, Radosevich MT, Dhingra S, Heitzeneder S, Tousley A, Lattin J, Xu P, Huang J, Nasholm N, He A, Kuo TC, Sangalang ERB, Pons J, Barkal A, Brewer RE, Marjon KD, Vilches-Moure JG, Marshall PL, Fernandes R, Monje M, Cochran JR, Sorensen PH, Daldrup-Link HE, Weissman IL, Sage J, Majeti R, Bertozzi CR, Weiss WA, Mackall CL, Majzner RG. Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication. Nat Med. 2022 Jan 13. doi: 10.1038/s41591-021-01625-x. Epub ahead of print. PMID: 35027753.

Duan H, Baratto L, Hatami N, Liang T, Mari Aparici C, Davidzon GA, Iagaru A. 68Ga-PSMA11 PET/CT for biochemically recurrent prostate cancer: Influence of dual-time and PMT- vs SiPM-based detectors. Transl Oncol. 2022 Jan;15(1):101293. doi: 10.1016/j.tranon.2021.101293. Epub 2021 Nov 22. PMID: 34823095; PMCID: PMC8626686.

Wang H, Hu Z, Sukumar UK, Bose RJ, Telichko A, Dahl JJ, Paulmurugan R. Ultrasound-Guided Microbubble-Mediated Locoregional Delivery of Multiple MicroRNAs Improves Chemotherapy in Hepatocellular Carcinoma. Nanotheranostics. 2022 Jan 1;6(1):62-78. doi: 10.7150/ntno.63320. PMID: 34976581; PMCID: PMC8671967.

Reviews (pending)

Original research (reverse chronological)

Partial listing:

Special Nanotheranostics issue dedicated to Sam Gambhir and MIPS alum Moritz Kircher, including MIPS co-authored articles.

Poplack SP, Young CA, Hagemann IS, Luo J, Herman CR, Wiele K, Li S, Zeng Y, Covington MF, Zhu Q. Prospective assessment of adjunctive ultrasound-guided diffuse optical tomography in women undergoing breast biopsy: Impact on BI-RADS assessments. Eur J Radiol. 2021 Dec;145:110029. doi: 10.1016/j.ejrad.2021.110029. Epub 2021 Nov 13. PMID: 34801874.

Kheirolomoom A, Kare AJ, Ingham ES, Paulmurugan R, Robinson ER, Baikoghli M, Inayathullah M, Seo JW, Wang J, Fite BZ, Wu B, Tumbale SK, Raie MN, Cheng RH, Nichols L, Borowsky AD, Ferrara KW. In situ T-cell transfection by anti-CD3-conjugated lipid nanoparticles leads to T-cell activation, migration, and phenotypic shift. Biomaterials. 2021 Dec 29;281:121339. doi: 10.1016/j.biomaterials.2021.121339. Epub ahead of print. PMID: 35078042.

Rao VL, Prolo LM, Santoro JD, Zhang M, Quon JL, Jin M, Iyer A, Yedavalli V, Lober RM, Steinberg GK, Yeom KW, Grant GA. Acetazolamide-Challenged Arterial Spin Labeling Detects Augmented Cerebrovascular Reserve After Surgery for Moyamoya. Stroke. 2021 Dec 6:STROKEAHA121036616. doi: 10.1161/STROKEAHA.121.036616. Epub ahead of print. PMID: 34865510.

Yu JH, Steinberg I, Davis RM, Malkovskiy AV, Zlitni A, Radzyminski RK, Jung KO, Chung DT, Curet LD, D'Souza AL, Chang E, Rosenberg J, Campbell J, Frostig H, Park SM, Pratx G, Levin C, Gambhir SS. Noninvasive and Highly Multiplexed Five-Color Tumor Imaging of Multicore Near-Infrared Resonant Surface-Enhanced Raman Nanoparticles In Vivo. ACS Nano. 2021 Dec 28;15(12):19956-19969. doi: 10.1021/acsnano.1c07470. Epub 2021 Nov 19. PMID: 34797988.

Zhang M, Zhou Q, Huang C, Chan CT, Wu W, Li G, Lim M, Gambhir SS, Daldrup-Link HE. In Vivo Evaluation of Near-Infrared Fluorescent Probe for TIM3 Targeting in Mouse Glioma. Mol Imaging Biol. 2021 Nov 30. doi: 10.1007/s11307-021-01667-0. Epub ahead of print. PMID: 34846678.

Nakamoto R, Ferri V, Duan H, Hatami N, Goel M, Rosenberg J, Kimura R, Wardak M, Haywood T, Kellow R, Shen B, Park W, Iagaru A, Gambhir SS. Pilot-phase PET/CT study targeting integrin αvβ6 in pancreatic cancer patients using the cystine-knot peptide-based 18F-FP-R01-MG-F2. Eur J Nucl Med Mol Imaging. 2021 Nov 3. doi: 10.1007/s00259-021-05595-7. Epub ahead of print. PMID: 34729628.

Wang K, Kumar US, Sadeghipour N, Massoud TF, Paulmurugan R. A Microfluidics-Based Scalable Approach to Generate Extracellular Vesicles with Enhanced Therapeutic MicroRNA Loading for Intranasal Delivery to Mouse Glioblastomas. ACS Nano. 2021 Nov 1. doi: 10.1021/acsnano.1c07587. Epub ahead of print. PMID: 34723509.

Kumar US, Afjei R, Ferrara K, Massoud TF, Paulmurugan R. Gold-Nanostar-Chitosan-Mediated Delivery of SARS-CoV-2 DNA Vaccine for Respiratory Mucosal Immunization: Development and Proof-of-Principle. ACS Nano. 2021 Oct 27:acsnano.1c05002. doi: 10.1021/acsnano.1c05002. Epub ahead of print. PMID: 34705425; PMCID: PMC8565460.

Lucia Baratto receives the Alavi-Mandell Award for this publication.
Baratto L, Hawk KE, States L, Qi J, Gatidis S, Kiru L, Daldrup-Link HE. PET/MRI Improves Management of Children with Cancer. J Nucl Med. 2021 Oct;62(10):1334-1340. doi: 10.2967/jnumed.120.259747. PMID: 34599010; PMCID: PMC8724894.

Khan S, Shin JH, Ferri V, Cheng N, Noel JE, Kuo C, Sunwoo JB, Pratx G. High-resolution positron emission microscopy of patient-derived tumor organoids. Nat Commun. 2021 Oct 7;12(1):5883. doi: 10.1038/s41467-021-26081-6. PMID: 34620852; PMCID: PMC8497512.

Theruvath AJ, Siedek F, Yerneni K, Muehe AM, Spunt SL, Pribnow A, Moseley M, Lu Y, Zhao Q, Gulaka P, Chaudhari A, Daldrup-Link HE. Validation of Deep Learning-based Augmentation for Reduced 18F-FDG Dose for PET/MRI in Children and Young Adults with Lymphoma. Radiol Artif Intell. 2021 Oct 6;3(6):e200232. doi: 10.1148/ryai.2021200232. PMID: 34870211; PMCID: PMC8637226.

Chen M, Chen Z, Castillo JB, Cui L, Zhou K, Shen B, Xie J, Chin FT, Rao J. [18F]-C-SNAT4: an improved caspase-3-sensitive nanoaggregation PET tracer for imaging of tumor responses to chemo- and immunotherapies. Eur J Nucl Med Mol Imaging. 2021 Oct;48(11):3386-3399. doi: 10.1007/s00259-021-05297-0. Epub 2021 Mar 13. PMID: 33712870.

Caudill C, Perry JL, Iliadis K, Tessema AT, Lee BJ, Mecham BS, Tian S, DeSimone JM. Transdermal vaccination via 3D-printed microneedles induces potent humoral and cellular immunity. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2102595118. doi: 10.1073/pnas.2102595118. PMID: 34551974; PMCID: PMC8488660.

Nobashi TW, Mayer AT, Xiao Z, Chan CT, Chaney AM, James ML, Gambhir SS. Whole-body PET Imaging of T-cell Response to Glioblastoma. Clin Cancer Res. 2021 Dec 1;27(23):6445-6456. doi: 10.1158/1078-0432.CCR-21-1412. Epub 2021 Sep 21. PMID: 34548318; PMCID: PMC8639766.

Gonzalez-Montoro A, Pourashraf S, Lee MS, Cates JW, Levin CS. Study of optical reflectors for a 100ps coincidence time resolution TOF-PET detector design. Biomed Phys Eng Express. 2021 Sep 15;7(6):10.1088/2057-1976/ac240e. doi: 10.1088/2057-1976/ac240e. PMID: 34488203; PMCID: PMC8548986.

Beinat C, Patel CB, Haywood T, Murty S, Naya L, Castillo JB, Reyes ST, Phillips M, Buccino P, Shen B, Park JH, Koran MEI, Alam IS, James ML, Holley D, Halbert K, Gandhi H, He JQ, Granucci M, Johnson E, Liu DD, Uchida N, Sinha R, Chu P, Born DE, Warnock GI, Weissman I, Hayden-Gephart M, Khalighi M, Massoud TF, Iagaru A, Davidzon G, Thomas R, Nagpal S, Recht LD, Gambhir SS. A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2-Induced Glycolytic Reprogramming in Glioblastoma. Clin Cancer Res. 2021 Dec 1;27(23):6467-6478. doi: 10.1158/1078-0432.CCR-21-0544. Epub 2021 Sep 2. PMID: 34475101; PMCID: PMC8639752.

Zhu Q, Ademuyiwa FO, Young C, Appleton C, Covington MF, Ma C, Sanati S, Hagemann IS, Mostafa A, Uddin KMS, Grigsby I, Frith AE, Hernandez-Aya LF, Poplack SS. Early Assessment Window for Predicting Breast Cancer Neoadjuvant Therapy using Biomarkers, Ultrasound, and Diffuse Optical Tomography. Breast Cancer Res Treat. 2021 Aug;188(3):615-630. doi: 10.1007/s10549-021-06239-y. Epub 2021 May 10. PMID: 33970392; PMCID: PMC8487763.

Ha B, Kim TJ, Moon E, Giaccia AJ, Pratx G. Flow radiocytometry using droplet optofluidics. Biosens Bioelectron. 2021 Dec 15;194:113565. doi: 10.1016/j.bios.2021.113565. Epub 2021 Aug 13. PMID: 34492500; PMCID: PMC8530933.

Reviews (pending)

Original research

Partial listing:

Song H, Harrison C, Duan H, Guja K, Hatami N, Franc BL, Moradi F, Aparici CM, Davidzon GA, Iagaru A. Prospective Evaluation of 18F-DCFPyL PET/CT in Biochemically Recurrent Prostate Cancer in an Academic Center: A Focus on Disease Localization and Changes in Management. J Nucl Med. 2020 Apr;61(4):546-551. doi: 10.2967/jnumed.119.231654. Epub 2019 Oct 18. PMID: 31628216.

Imaging Biology

Stevens MY, Cropper HC, Lucot KL, Chaney AM, Lechtenberg KJ, Jackson IM, Buckwalter MS, James ML. Development of a CD19 PET tracer for detecting B cells in a mouse model of multiple sclerosis. J Neuroinflammation. 2020 Sep 18;17(1):275. doi: 10.1186/s12974-020-01880-8. PMID: 32948198; PMCID: PMC7501720.

Wardak M, Gowrishankar G, Zhao X, Liu Y, Chang E, Namavari M, Haywood T, Gabr MT, Neofytou E, Chour T, Qin X, Vilches-Moure JG, Hardy J, Contag CH, McConnell MV, Wu JC, Gambhir SS. Molecular Imaging of Infective Endocarditis With 6''-[18F]Fluoromaltotriose Positron Emission Tomography-Computed Tomography. Circulation. 2020 May 26;141(21):1729-1731. doi: 10.1161/CIRCULATIONAHA.119.043924. Epub 2020 May 26. PMID: 32453662.

Cipriano PW, Yoon D, Holley D, Hargreaves BA, Carroll IR, Curtin CM, Biswal S. Diagnosis and Successful Management of an Unusual Presentation of Chronic Foot Pain Using Positron Emission Tomography/Magnetic Resonance Imaging and a Simple Surgical Procedure. Clin J Sport Med. 2020 Jan;30(1):e11-e14. doi: 10.1097/JSM.0000000000000651. PMID: 30908328; PMCID: PMC6752992.

Image-Guided Drug Delivery

Kumar SU, Telichko AV, Wang H, Hyun D, Johnson EG, Kent MS, Rebhun RB, Dahl JJ, Culp WTN, Paulmurugan R. Acoustically Driven Microbubbles Enable Targeted Delivery of microRNA-Loaded Nanoparticles to Spontaneous Hepatocellular Neoplasia in Canines. Adv Ther (Weinh). 2020 Dec;3(12):2000120. doi: 10.1002/adtp.202000120. Epub 2020 Nov 12. PMID: 33415184; PMCID: PMC7784952.

Seo JW, Ingham ES, Mahakian L, Tumbale S, Wu B, Aghevlian S, Shams S, Baikoghli M, Jain P, Ding X, Goeden N, Dobreva T, Flytzanis NC, Chavez M, Singhal K, Leib R, James ML, Segal DJ, Cheng RH, Silva EA, Gradinaru V, Ferrara KW. Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation. Nat Commun. 2020 Apr 30;11(1):2102. doi: 10.1038/s41467-020-15818-4. PMID: 32355221; PMCID: PMC7193641.

Cui L, Gouw AM, LaGory EL, Guo S, Attarwala N, Tang Y, Qi J, Chen YS, Gao Z, Casey KM, Bazhin AA, Chen M, Hu L, Xie J, Fang M, Zhang C, Zhu Q, Wang Z, Giaccia AJ, Gambhir SS, Zhu W, Felsher DW, Pegram MD, Goun EA, Le A, Rao J. Mitochondrial copper depletion suppresses triple-negative breast cancer in mice. Nat Biotechnol. 2021 Mar;39(3):357-367. doi: 10.1038/s41587-020-0707-9. Epub 2020 Oct 19. PMID: 33077961; PMCID: PMC7956242.

Image-Based Cellular Therapies

Jung KO, Kim TJ, Yu JH, Rhee S, Zhao W, Ha B, Red-Horse K, Gambhir SS, Pratx G. Whole-body tracking of single cells via positron emission tomography. Nat Biomed Eng. 2020 Aug;4(8):835-844. doi: 10.1038/s41551-020-0570-5. Epub 2020 Jun 15. PMID: 32541917; PMCID: PMC7423763.

Nejadnik H, Jung KO, Theruvath AJ, Kiru L, Liu A, Wu W, Sulchek T, Pratx G, Daldrup-Link HE. Instant labeling of therapeutic cells for multimodality imaging. Theranostics. 2020 May 15;10(13):6024-6034. doi: 10.7150/thno.39554. PMID: 32483435; PMCID: PMC7255004.

Ullah M, Liu DD, Rai S, Dadhania A, Jonnakuti S, Concepcion W, Thakor AS. Reversing Acute Kidney Injury Using Pulsed Focused Ultrasound and MSC Therapy: A Role for HSP-Mediated PI3K/AKT Signaling. Mol Ther Methods Clin Dev. 2020 Mar 30;17:683-694. doi: 10.1016/j.omtm.2020.03.023. PMID: 32346546; PMCID: PMC7177168.

Novel Platforms

Yim JJ, Singh SP, Xia A, Kashfi-Sadabad R, Tholen M, Huland DM, Zarabanda D, Cao Z, Solis-Pazmino P, Bogyo M, Valdez TA. Short-Wave Infrared Fluorescence Chemical Sensor for Detection of Otitis Media. ACS Sens. 2020 Nov 25;5(11):3411-3419. doi: 10.1021/acssensors.0c01272. Epub 2020 Nov 11. PMID: 33175516.

Tadesse LF, Ho CS, Chen DH, Arami H, Banaei N, Gambhir SS, Jeffrey SS, Saleh AAE, Dionne J. Plasmonic and Electrostatic Interactions Enable Uniformly Enhanced Liquid Bacterial Surface-Enhanced Raman Scattering (SERS). Nano Lett. 2020 Oct 14;20(10):7655-7661. doi: 10.1021/acs.nanolett.0c03189. Epub 2020 Oct 4. PMID: 32914987; PMCID: PMC7564787.

Park SM, Won DD, Lee BJ, Escobedo D, Esteva A, Aalipour A, Ge TJ, Kim JH, Suh S, Choi EH, Lozano AX, Yao C, Bodapati S, Achterberg FB, Kim J, Park H, Choi Y, Kim WJ, Yu JH, Bhatt AM, Lee JK, Spitler R, Wang SX, Gambhir SS. A mountable toilet system for personalized health monitoring via the analysis of excreta. Nat Biomed Eng. 2020 Jun;4(6):624-635. doi: 10.1038/s41551-020-0534-9. Epub 2020 Apr 6. Erratum in: Nat Biomed Eng. 2020 May 7;: PMID: 32251391; PMCID: PMC7377213.

Si P, Shevidi S, Yuan E, Yuan K, Lautman Z, Jeffrey SS, Sledge GW, de la Zerda A. Gold Nanobipyramids as Second Near Infrared Optical Coherence Tomography Contrast Agents for in Vivo Multiplexing Studies. Nano Lett. 2020 Jan 8;20(1):101-108. doi: 10.1021/acs.nanolett.9b03344. Epub 2019 Oct 10. PMID: 31585502.

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