This laboratory is focused on understanding tumor and normal tissue radiation response through the development and application of molecular imaging techniques. This goal is pursued through work spanning technique development, basic research, and clinical translation. We are a multi-disciplinary group with expertise in engineering, biology, chemistry, medicine, and computer science, and have developed a variety of methods of noninvasively detecting and quantifying molecular and physiologic aspects of radiation and tumor biology, including oxygen concentrations, hypoxia-regulated gene expression, metabolism, and cell migration. In addition, in order to evaluate the relevance of these molecular factors to clinical radiation therapy, we have developed a system for the delivery of clinically-similar image-guided conformal radiotherapy to small animals. This myriad of tools is being applied to elucidate the molecular, cellular, and clinical consequences of radiation exposure and cancer therapy.
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