This laboratory is focusing on the development of non-invasive imaging methods to image tumor-specific molecular markers such as mRNAs of oncogenes and over-expressed proteinases for better understanding of tumor biology. Towards this goal, we take an interdisciplinary approach of combining synthetic and physical organic chemistry, molecular biology with imaging techniques such as fluorescence microscopy, whole body fluorescence/bioluminescence imaging. A recent emphasis in the lab is to apply nanotechnology to develop novel nanosensors for bioimaging and tumor detection.
The Dionne lab is passionate about solving challenges in global health and sustainability with nanophotonics. We imagine a world where diseases like cancer, COVID, and tuberculosis are detected and cured with light. We develop new nanomaterials and nanophotonic imaging platforms with translational impact, using a feedback loop between advanced computational and characterization platforms spanning the molecular to cellular level. We are a diverse team of materials scientists, radiologists, chemists, applied physicists, electrical engineers, chemical engineers, and bioengineers, and we work closely with collaborators in the clinical virology and pathology labs, as well as with surgeons.
Our NIH-funded team of basic science researchers and physician scientists develops novel imaging solutions for pediatric patients with the goal to tackle significant problems encountered in clinical practice. We have extensive expertise in pre-clinical development and clinical translation of novel imaging technologies at the intersection of cell biology, nanomedicine and medical imaging: We developed “one stop” imaging tests for pediatric cancer staging, theranostic nanoparticles for cancer therapy without side effects, and patented techniques for stem cell tracking in patients. We recently initiated a collaborative program with 20 faculty from 9 Departments, who develop an imaging test for prediction and early treatment of tissue injuries after chemotherapy (PREDICT). Over the past 10 years, our team members received 77 honors and awards.
Prof. Wang and his group are engaged in the research of magnetic nanotechnologies and information storage in general, including magnetic biochips, in vitro diagnostics, cell sorting, magnetic nanoparticles, nano-patterning, spin electronic materials and sensors, magnetic inductive heads, as well as magnetic integrated inductors and transformers. He uses modern thin-film growth techniques, lithography, and nanofabrication to engineer new electromagnetic materials and devices and to study their behavior at nanoscale and at very high frequencies. His group is investigating magnetic nanoparticles, high saturation soft magnetic materials, giant magnetoresistance spin valves, magnetic tunnel junctions, and spin electronic materials, with applications in cancer nanotechnology, in vitro diagnostics, spin-based information processing, efficient energy conversion and storage, and extremely high-density magnetic recording. Nanotechnology can make a positive impact to in-vitro and in-vivo diagnostics of cancer and other complex diseases.
My laboratory is developing imaging assays to monitor fundamental cellular/molecular events in living subjects including patients. Technologies such as positron emission tomography (PET), optical (fluorescence, bioluminescence, Raman), ultrasound, and photoacoustic imaging are all under active investigation.
Imaging agents for multiple modalities including small molecules, engineered proteins, and nanoparticles are under development and being clinically translated. Our goals are to detect cancer early and to better manage cancer through the use of both in vitro diagnostics and molecular imaging. Strategies are being tested in small animal models and are also being clinically translated.