This laboratory is currently focusing on three major areas of research: 1) rapid detection and imaging of bacterial infection, especially antibiotics-resistant bacteria and mycobacterium tuberculosis (MTB), 2) understanding and imaging tumor response to treatment, and 3) imaging-guided tumor resection. Towards these goals, we are developing new molecular probes and imaging strategies to image and interrogate a broad range of molecular targets, from enzymes like hydrolases (beta-lactamases), proteases (such as caspases and MMPs), DNA polymerases (PARP-1), to reactive oxygen species (ROS). We also exploring nanoparticles and developing nanotechnologies in order to improve the sensitivity and specificity of detection and imaging. Through innovation in probe chemistry and nanotechnology, we strive to provide new solutions to these important problems in global health, cancer biology and therapy.
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