Fall 2016 BioEngineering 222/Radiology 222
Multimodality Molecular imaging in Living Subjects
Instructors
Course Logistics
| Classes: | Mondays and Fridays 8:30-10:20 AM CCSR4107 |
| Reference Materials: |
Molecular Imaging: Principles and Practice
Weissleder R, Ross BD, Rehemtulla A, Gambhir SS
2010 People's Medical Publishing House
On reserve at
Lane Library
Molecular Imaging with Reporter Genes
Edited by Gambhir SS & Yaghoubi S
2010 Cambridge University Press
On reserve at
Lane Library
| Grading: | 20% class participation, 40% midterm, 40% final exam |
| Exams: | November 4, 2016 Mid-term Exam December 12, 2016 - Final Exam 8:30- 11:30am Center for Clinical Science Research RSRC 4107 |
Course Syllabus
| Week | Monday | Instructor | Friday | Instructor |
| 1 | 9/26 | Tours of Small Animal Imaging Facility and Molecular Imaging ClinicC. Levin |
9/30 | Radiation/Radionuclide PhysicsEmission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 4 |
| 2 | 10/3 | Tomographic Image Reconstruction
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10/7 | Positron Emission Tomography (PET)Molecular Imaging: Principles and Practice Chapter 7 Molecular Imaging with Reporter Genes Chapter 7 Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 10 |
| 3 | 10/10 | Single Photon Emission Computed Tomography (SPECT)Molecular Imaging: Principles and Practice Molecular Imaging with Reporter Genes Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapters 7, 8 |
10/14 |
Ultrasound Imaging PhysicsAnderson ME. A seminar on k-space applied to medical ultrasound. 1997. Chapters 1 & 2. Diagnostic Ultrasound Imaging: Inside Out.. Academic Press, 2013. Chapter 14 (free to Stanford students) Dahl J. Ultrasound Beam Forming and Image Formation. RSNA 2005:63-71. |
| 4 | 10/17 | Molecular Ultrasound |
10/21 | X-ray Computed Tomography (CT) |
| 5 | 10/24 | Visible Light OpticsGoing deeper than microscopy: the optical imaging frontier in biology. Nature Methods 2010;7(8):603-614. Lohmann AW. Scaling laws for lens systems. Appl Opt. 1989 Dec 1;28(23):4996-8. |
10/28 | Fluorescence Imaging & TomographyGraves EE. A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med. Phys. 2003;30(5):901-911. Ntziachristos V. Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation. Opt Lett. 2001 Jun 15;26(12):893-5. Patterson MS. Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. Appl Opt. 1989 Jun 15;28(12):2331-6d. |
| 5 | 10/31 | Bioluminescence Imaging & TomographyContag C. It's not just about anatomy: in vivo bioluminescence imaging as an eyepiece into biology. J Magn Reson Imaging. 2002 Oct;16(4):378-87. Kuo C. Three-dimensional reconstruction of in vivo bioluminescent sources based on multispectral imaging. J Biomed Optics 2007;12(2): 024007. |
11/4 | Mid-Term Exam |
| 5 | 11/7 | Molecular & Cellular MRI |
11/11 | Nuclear Magnetic Resonance (NMR) and MR Imaging Physics |
| 6 | 11/14 | Optical Fluorescence EndoscopyBrady DJ. Multiscale lens design. Opt Express. 2009 Jun 22;17(13):10659-74. Ghosh KK. Miniaturized integration of a fluorescence microscope. Nat Methods. 2011 Sep 11;8(10):871-8. Liu J. Point-of-care pathology with miniature microscopes. Anal Cell Pathol (Amst). 2011;34(3):81-98. Völkel R. Miniaturized imaging systems. Microelectronic Engineering 2003;67–68:461–472. |
11/18 | Photoacoustic Tomography (PAT) |
Thanksgiving Holiday
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| 7 | 11/28 | Raman Scatter ImagingAustin LA.Raman technologies in cancer diagnostics. Analyst 2015. Raman CV. A New Type of Seconday Radiation.Nature 1928. Zavaleta C. Raman's "Effect" on Molecular Imaging. JNM 2011;52(11):1839-1844. |
12/2 | Magnetic Partical ImagingS. Conolly Gleich B. Tomographic imaging using the nonlinear response of magnetic particles. Nature. 2005 Jun 30;435(7046):1214-7. Lu K. Linearity and shift invariance for quantitative magnetic particle imaging. IEEE Trans Med Imaging. 2013 Sep;32(9):1565-75. Zheng B. Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo. Theranostics. 2016 Jan 1;6(3):291-301. |
| 8 | 12/5 | X-ray Fluorescence Tomography |
12/9 | Multimodality Molecular Imaging Technology Currently in the Clinic: PET/CT and PET/MRMolecular Imaging: Principles and PracticeChapter 7 Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 11 |
| 10 | 12/12 | Final Exam8:30- 11:30amCenter for Clinical Science Research RSRC 4107 |
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