Welcome to the Meffre Lab
We explore the molecular and cellular origins of autoimmune disorders. Leveraging humanized mice and rare genetic samples, we study how autoreactive B cells are produced and promote autoimmunity. Our research by Elif Çakan has shown that TLR9 plays an essential role in the establishment of central B cell tolerance and thereby challenged the B-cell receptor-centric paradigm of its regulation. Our ultimate goal is to develop novel strategies to restore impaired central and peripheral B cell tolerance checkpoints in patients with autoimmune syndromes and thwart autoimmunity.
Our Research
From central selection to the periphery, we’re working at the forefront of human B cell tolerance.
Meet Our Team
Meet the lab members continuing a 20-year legacy of immunologic inquiry and discovery.
Open Positions
Positions in the Meffre lab are available upon request.
