2024
12:00 PM - 01:00 PM
Tuesday Tue
Location
Stanford University School of Medicine
291 Campus DrStanford, CA 94305
Medical Physics Seminar - Kai Jiang
High-Throughput Irradiation Platforms for Small-Animal FLASH Research and Preliminary Radiobiological Outcomes
Time:
12:00pm – 1:00pm Seminar & Discussion
Location:
Zoom Webinar
Webinar Registration:
https://stanford.zoom.us/webinar/register/WN_Y5QwpIWMQ3ugvdnzT_iyEQ
Check your email for the Zoom webinar link after you have registered
Speaker
Dr. Kai Jiang, Ph.D., Assistant Professor of Radiation Oncology at University of Maryland, School of Medicine
Dr. Jiang received his Ph.D. in Biomedical Engineering at the Department of Biomedical Engineering, Case Western Reserve University in Cleveland, OH. After a few years’ postdoctoral training at the Mayo Clinic, he continued his journey in medical physics and completed the medical physics residency at University of Maryland Medical Center in June 2021. Then he was appointed as an assistant professor there. Now he devotes 60% his time working as a clinical medical physicist at the University of Maryland Medical System. Besides, he serves as the director of preclinical physics at the Division of Translational Radiation Science. He supervises physics activities in the prestigious medical countermeasure program utilizing preclinical kV irradiators (XRAD-320 and SARRP) and clinical linear accelerators. He also directs the preclinical imaging program for translational research. Dr. Jiang is intensively involved in research studies investigating the FLASH effects of ultra-high dose rate electron and proton beams using preclinical models of human cancer.
Abstract
The normal tissue sparing and iso-effective tumor control (FLASH effect) of ultra-high dose rate (UHDR) radiation hold promises for increased therapeutic window in cancer radiotherapy. However, the underpinning mechanisms and optimal UHDR parameters (dose, dose rate, etc.) for the FLASH effect remain unclear for different organ and tissue types. Investigating these problems necessities large-scale animal studies, for which efficient and high-throughput irradiation platforms are needed. In the last few years, we have developed and commissioned a spectrum of such platforms to facilitate preclinical FLASH studies using UHDR electron beams at University of Maryland, Baltimore. Meanwhile, the first hemi-thoracic lung irradiation study using UHDR proton pencil beams has been completed with the aim to inform clinical translations at the Maryland Proton Treatment Center. The preliminary results suggest UHDR protons have differential effects to the skin and lung. In this seminar, Dr. Kai Jiang will present those high-throughput eFLASH platforms and preliminary findings from the pFLASH study.