How exercise training delivered via video conferencing helps kids improve their cardiovascular health
By Laura Hedli
Seda Tierney, MD, associate professor of pediatric cardiology and the Stanford Maternal and Child Health Research Institute Faculty Scholar, shows how telehealth exercise interventions are feasible and effective for pediatric cardiac patients.
MCHRI expands dedicated clinical research coordination support to investigators
MCHRI expands its Clinical Research Coordination Support services to assist divisions with hiring and onboarding division-dedicated clinical research coordinators who will assist investigators in the design, start-up, and execution of clinical research studies.
New Program Director for the MCHRI Uytengsu-Hamilton 22q11 Neuropsychiatry Research Program
Program Director, Rachel Panizzo, PhD, will oversee the MCHRI Uytengsu-Hamilton 22q11 Neuropsychiatry Research Program's scientific portfolio, strategy development, long-range planning, and partnership development to advance research in the 22q11 Deletion Syndrome.
Stanford Medicine Research Registry now accepting children and adult dependents
The Stanford Medicine Research Registry is a simple and secure process that determines participant’s eligibility for research studies at Stanford Medicine. Children and adult dependents can now join the research registry.
*NEW UPDATES* Online requests for remote monitor access to Stanford Children’s Health Epic
Effective June 18, MCHRI is accepting online requests for remote monitor access to Stanford Children’s Health Epic. This updated monitor access request process requires additional information that reflects new requirements mandated by hospital Privacy.
Director's Message for July 2020
David K. Stevenson, MD, Co-Director of MCHRI, writes about the Institute’s goal to enable the translation of discoveries into diagnostics and therapeutics through strategic partnerships, training and education, and quality research support to conduct studies at Stanford Children's Health.
MCHRI scholar's work on the future of diabetes: Improving islet transplantation
Avnesh Thakor, MD, PhD, assistant professor pediatric radiology and MCHRI scholar, and his team are developing a bioscaffold that helps insulin-producing cells get enough oxygen when transplanted for diabetes treatment. This research was addressed in a recent paper published in Advanced Functional Materials and supported in part by MCHRI.
Inspired by her sister’s resilience, psychiatrist and MCHRI scholar aspires to instill hope in others
In this JAMA publication, Manpreet Singh, MD, associate professor of psychiatry and behavioral sciences and MCHRI scholar, draws inspiration from her sister - who was born prematurely with congenital heart disease and Down syndrome - as she strives to instill hope in people who feel hopeless.
Stanford develops an experimental two-in-one shot that could aid diabetics
A Stanford research team has developed a way to boost the effectiveness of the insulin injections people with diabetes routinely take to control their blood sugar. Eric Appel, MS, PhD, assistant professor of materials science and engineering, is senior author of this study funded in part by MCHRI.
Director's Message for June 2020
Karl Sylvester, MD, Director of Clinical Research Support Office, writes about exciting progress towards CRSO’s mission to support and enhance the clinical research across Stanford Children’s Health, including developing relationship with the Department of Nursing Research and Evidence-Based Practice.
New advances toward safely targeting immune cells to pediatric brain tumors
Stanford scientists have taken important steps toward figuring out how to use immune therapy for a group of severe pediatric brain tumors. Crystal Mackall, MD, professor of pediatrics and of medicine and MCHRI member, is senior author of the study.
Brain-scan abnormalities found in children with PANS
Subtle abnormalities occur in key brain structures of children diagnosed with pediatric acute-onset neuropsychiatric syndrome, according to a new Stanford study. The study's co-lead author, Jennifer Frankovich, MD, clinical associate professor of pediatrics, and senior author, Kristen Yeom, MD, associate professor of radiology, are MCHRI members.
New advances toward safely targeting immune cells to pediatric brain tumors
Stanford scientists have taken important steps toward figuring out how to use immune therapy for a group of severe pediatric brain tumors. Crystal Mackall, MD, professor of pediatrics and of medicine and MCHRI member, is senior author of the study.
Director's Message for May 2020
In this message, MCHRI Co-Director, Anthony Oro, MD, PhD, writes about the challenges brought on by the novel coronavirus (COVID-19) and the opportunities for the research community and MCHRI to innovate in several ways.
Study finds stronger one-way fear signals in brains of anxious kids
Stanford study shows signals from the brain’s fear center make it more difficult for anxious and stressed children to regulate their emotions. Vinod Menon, PhD, Professor of Psychiatry and Behavioral Sciences, is the senior author of this study supported in part by MCHRI.
Helping children turn failures into success through growth mindset
This In the Spotlight features Irene Loe, MD, assistant professor of pediatrics, who talks about her five-year passion project to help parents cultivate a growth mindset in their children. Dr. Loe is the Akiko Yamazaki and Jerry Yang Faculty Scholar.
Young adults don’t know what’s in nicotine products they vape
Nicotine pods used for vaping need clearer labels to help young people understand what they are inhaling, a Stanford study concludes. Bonnie Halpern-Felsher, PhD, Professor of Pediatrics, is the senior author, and Karma McKelvey, PhD, postdoctoral scholar and an MCHRI awardee, is lead author on the study.
High risk of tuberculosis in kids exposed to the disease
Stanford study shows young children exposed to tuberculosis are at a high risk of developing the disease. The study’s lead author is Leonardo Martinez, PhD, a postdoctoral scholar, and the senior author is Jason Andrews, MD, assistant professor of medicine and an MCHRI member.
MCHRI practices social distancing while still staying connected
Staff members of MCHRI practice social distancing while using virtual tools to stay connected with colleagues and researchers.
*New Funding Opportunity* MCHRI receives new gift to support clinician educator pilot grant dedicated to pediatric primary sclerosing cholangitis
Made possible by a donor gift to MCHRI, the Institute will offer a new funding opportunity within the Clinician Educator Pilot Grant Program focused on pediatric primary sclerosing cholangitis (PSC). The first grant will be offered this spring cycle with deadline on April 1st.
Virtual Pediatric Grand Rounds: Novel coronavirus (COVID-19) updates
Yvonne (Bonnie) Maldonado, MD, Senior Associate Dean for Faculty Development and Diversity and Professor of Pediatrics and of Epidemiology and Population Health, presents updates on COVID-19. She is an MCHRI awardee.
Virtual Pediatric Grand Rounds: How Taiwan effectively responded to COVID-19
C. Jason Wang, MD, PhD, Associate Professor of Pediatrics and of Medicine, describes how Taiwan responded quickly to protect its people from the novel coronavirus (COVID-19) in this webinar and recent JAMA study. Dr. Wang is Co-Director of the PCHA-UHA Research and Learning Collaborative, a funded partner of MCHRI.
MCHRI welcomes new quantitative science faculty to facilitate maternal and child health research
MCHRI’s partnership with the Quantitative Sciences Unit leads to the appointment of a new pediatric faculty member, Maya Mathur, PhD, to facilitate maternal and child health research studies initiated by Stanford investigators.
*New Update* How to acknowledge MCHRI funding in your work
MCHRI has provided guidelines for communicating and acknowledging the Institute's funding in your presentations, papers, posters, and press releases.
MCHRI streamlines research at Stanford Children’s Health
MCHRI is co-leading a collaborative effort to make it easier to conduct research at Stanford Children’s Health, accelerating the incorporation of breakthrough discoveries into clinical care, a central goal of the hospital’s 2025 strategic vision.
Dr. Mary Leonard Elected to American Pediatric Society
Mary Leonard, MD, MSCE, professor and chair of the Department of Pediatrics and director of MCHRI, has been elected to the American Pediatric Society (APS). She will serve as Vice-President from May 2020 to 2021 and President from May 2021 to 2022.
To prevent premature birth, computers ID drug that may help
A team of scientists trying to prevent premature births has turned to a new strategy: computer-assisted matchmaking. The Stanford-UCSF research suggests that a widely used antacid may be able to prevent pregnant women from going into labor early. Read more.
Teens vulnerable to social-media promotion of vaping
Social media posts promoting e-cigarettes appear able to make teens more willing to vape, new Stanford research has shown. The study's lead author is Erin Vogel, PhD, postdoctoral research fellow and an MCHRI member.
Visionary gift support research initiative to treat and find cures for single ventricle heart disease
Thanks to visionary gift from Additional Ventures, MCHRI joins Stanford School of Medicine and Stanford Children's Health in promoting innovative research in single ventricle heart disease.
MCHRI fuels diverse research through partnership with Stanford Diabetes Research Center
By Laura Hedli
Since 2016, MCHRI has partnered with the Stanford Diabetes Research Center (SDRC) to fund projects related to maternal and child health. By establishing an institutional commitment early on, SDRC has dramatically expanded by obtaining impactful federal funding and is supporting a wide array of projects in maternal and child health.
Expanded program helps researchers engage study participants
In partnership with MCHRI’s Clinical Research Support Office, the Research Participation Program within in the School of Medicine’s Research Office provides resources and tools to help researchers with recruiting participants for studies.
Dr. Gary Shaw Receives SPR's Douglas K. Richardson Award
MCHRI member and panel chair of the Pilot Grants Program, Gary Shaw, DrPH, professor of pediatrics, is the recipient of the Society for Pediatric Research 2020 Douglas K. Richardson award.
Parents can help build mental wellness in kids and teens at risk for bipolar
Involving parents in therapy boosts mental wellness among children and teens at risk for bipolar disorder, a Stanford-led study has found. Manpreet Singh, MD, MS, associate professor of psychiatry and behavioral sciences and an MCHRI awardee, is one of the study's co-authors.
Transdisciplinary approach to modeling heart mechanics
By Laura Hedli
Led by Associate Professor of Pediatrics and Bioengineering Alison Marsden, PhD, MCHRI TIP awardees combine mechanical and computational modeling with clinical data, leading to insights about pulmonary valve dysfunction.
5 Questions with Stanford's Preeclampsia Research Team
Lead by Co-PIs Drs. Virginia Winn, MD, PhD & Mark Hlatky, MD along with members from 12 Stanford Departments, this team recently received a $6 million grant from the NHLBI to study the connections between preeclampsia in pregnant women and heart diseases in later life.
Broad range of MCHRI awards support Faculty Scholar to understand and combat arboviral disease
By Laura Hedli
MCHRI Faculty Scholar A. Desiree LaBeaud, MD, MS, associate professor of pediatrics, is looking at the risk factors and long-term health consequences of arboviral infections affecting children and pregnant women.
*APPLY NOW* MCHRI Eureka Certificate Course in Translational Medicine
MCHRI is excited to announce its inaugural translational medicine course, MCHRI Eureka 2020 Certificate Course in Translational Medicine. This 5-day intensive course will be held at Asilomar Conference Center in Monterey, CA from February, 9 to February 13, 2020.
Apply for funding opportunity in 22q11 Deletion Syndrome Research
The MCHRI Uytengsu-Hamilton 22q11 Neuropsychiatry Research Awards Program aims to promote research to improve the neurocognitive outcomes and behavioral symptoms of 22q11 Deletion Syndrome with immediate (within 5 years) and long term impact.
5 Questions: Dennis Wall on new discoveries in autism genetics
Autism researcher discusses the findings of an analysis of the genome sequences for 2,308 people from 493 nuclear families affected by autism.
Registration open for MCHRI symposium
Stanford scientists, clinicians and others with an interest in maternal and child health are invited to attend the free symposium on campus November 15.
Now accepting abstracts for 2nd Annual Research Symposium, November 15
MCHRI invites you to its second annual research symposium on Friday, November 15, 2019! We are now accepting all abstracts focused in maternal and child health research which will be reviewed and selected to present during our poster sessions. Read more.
Register now for the 2nd Annual Research Symposium, November 15
Registration is now open for the second annual Stanford Maternal and Child Health Research Institute Symposium, which will highlight the latest research in maternal and child health across campus.
Stanford-led team receives $10 million award for myosin research
The NIGMS has awarded a five-year, $10 million grant to a multidisciplinary team of scientists led by Stanford researchers that will try to understand a common cause of heart failure.
Gender inequality and rigid norms linked with poor health, global research shows
Restrictive gender expectations hurt everyone's health, and understanding how this happens is the first step toward improving the situation around the world, according to a new series of papers published in The Lancet led by Gary Darmstadt, MD, professor of pediatrics and associate dean for maternal and child health.
A second chance at life
Two young brothers were born with IPEX syndrome, a life-threatening genetic disease that causes patients' immune systems to attack their own healthy tissues. Stanford physician-scientists and MCHRI awardees, Rosa Bacchetta, MD, and Alice Bertaina, MD, PhD, helped these brothers get a second chance at life.
Hormone reduces social impairment in kids with autism
Social behavior improved in children with autism after they inhaled a hormone called vasopressin, according to a pilot study led by Karen Parker, PhD, associate professor of psychiatry and behavioral sciences and Antonio Hardan, MD, professor of psychiatry and behavioral sciences. This research was supported by MCHRI.
New research links common brain injury in premature babies to specific cells
Stanford researchers have identified a specific set of brain cells that are particularly susceptible to harm from low oxygen exposure in early development. The work was led by Sergiu Pasca, MD, assistant professor of psychiatry and behavioral sciences, and Anca Pasca, MD, assistant professor of pediatrics. Both are MCHRI awardees.
Tobacco and e-cig promotions spark teens’ use of nicotine products
Many teens own e-cigarette samples, coupons or branded promotional items, and these teens are more likely to try the products, a Stanford study found. Bonnie Halpern-Felsher, PhD, professor of pediatrics and MCHRI member, is the study’s senior author.
Tad and Dianne Taube commit $6 million for pediatric cancer research
Philanthropists Tad and Dianne Taube have committed $6 million to the School of Medicine to establish the Taube Initiative in Pediatric Cancer Research. Their recent gifts include $1 million to support transdisciplinary research through MCHRI.
Women getting C-sections best judge of own pain medication needs
A recent research tested an approach that allowed women to choose the level of pain management they wanted during a cesarean section. MCHRI Faculty Scholar Brendan Carvalho, MD, professor of anesthesiology, perioperative and pain medicine, is lead author of the study.
How MCHRI is investing in research to reduce and prevent youth tobacco use
By Laura Hedli
Teen vaping is on the rise and researchers are searching for solutions to reduce and prevent tobacco use. MCHRI is supporting investigators to research the effects of e-cigarettes on the brain and body and to provide resources aimed at preventing the use of tobacco and nicotine among youth.
How MCHRI supports research for clinician educator to improve the quality of care for patients and their families
MCHRI awarded Annette Nasr, RN, PhD, the Clinician Educator Grant to support her study in living donation and the long-term emotional and relationship impact for both the donor and the recipient.
Treating parasite infections during pregnancy thought to boost babies’ immune responses
New research suggests that a specific change in prenatal care for pregnant women in developing countries may improve their babies’ vaccine responsiveness after birth. Desiree LaBeaud, MD, associate professor of pediatrics and an MCHRI awardee, is the co-author of this work describing the findings.
With metabolic profiles of children, new center hopes to head off disease early
Stanford’s new Metabolic Health Center aims to study metabolic profiles of babies, children, and pregnant women to understand the origins of disease. Co-directors include David K. Stevenson, MD, professor of pediatrics, and Karl Sylvester, MD, professor of pediatric surgery, who are MCHRI executive committee members.
Some viruses help protect harmful bacteria in cystic fibrosis patients
A recent study has shown some viruses help protect harmful bacteria in cystic fibrosis patients. Lead author, Elizabeth Burgener, MD, instructor of pediatrics, and co-authors, Paul Bollyky, MD, PhD, assistant professor of medicine and of microbiology and immunology, and Carlos Milla, MD, professor of pediatrics, were supported by MCHRI.
Stanford researchers outline the role of a deep brain structure in concussion
Through a combination of biometric tracking, simulated modeling and medical imaging, researchers detail how trauma to the side of the head cause concussion. This work was funded in part by MCHRI, with David Camarillo, PhD, assistant professor of bioengineering, as the co-lead author of the paper describing the findings.
Seed funding awarded at Pediatric Device Accelerator pitch competition
Last month, Stanford Children's Health, Stanford University School of Medicine, and MCHRI hosted the second annual Pediatric Innovation Showcase. The daylong event highlighted new devices and developments in pediatric medicine, as well as a pitch competition put on by the UCSF-Stanford Pediatric Device Consortium.
MCHRI provides support and ‘second set of eyes’ for investigator to make an impact in maternal health research
MCHRI awarded Stephanie Leonard, PhD, a postdoctoral fellowship and provided critical feedback during the review process to study the rise of pre-pregnancy health and cesarean delivery and the rise of life-threatening pregnancy complications.
Faculty Scholars explore impact of community-based intervention in the Tenderloin
By Laura Hedli
Can teaching growth mindset to parents help alter their children's behavior and learning? Irene Loe, MD, assistant professor of pediatrics, and Claudia Mueller, MD, associate professor of pediatric surgery, aim to find out in their collaborative research project based at a Bay Area elementary school.
Developmental origins and emerging therapeutic opportunities for childhood cancer
Cancer is the leading disease-related cause of death in children in developed countries. In a recent Nature Medicine article, Michelle Monje, MD, PhD, associate professor of neurology and neurological sciences and an MCHRI Faculty Scholar, is the co-author on this paper that reviews the developmental origins and emerging therapeutic opportunities for childhood cancer.
Set of genes predicts severity of dengue
Purvesh Khatri, PhD, associate professor of medicine and of biomedical data science, and Shirit Einav, MD, associate professor of medicine and of microbiology and immunology, are co-authors on a paper that have identified 20 genes that can predict an individual’s likelihood of developing a severe form of dengue fever with about 80 percent accuracy. This project was supported by SPARK, a funded partner of the MCHRI.
Congenital heart babies more likely to develop heart conditions as adults
An infant born with a relatively simple heart defect is far more likely to develop heart problems as an adult, according to Stanford researchers. James Priest, assistant professor of pediatrics and an MCHRI awardee, is the senior author of the paper summarizing the findings from the research.
Why are women affected by life-threatening complications in pregnancy and childbirth
Since 2004, the rate of life-threatening pregnancy complications has more than doubled, affecting more than 50,000 women in the U.S. Stephanie Leonard, PhD, postdoctoral fellow in pediatrics and an MCHRI awardee, is the lead author on a new study that uses California-wide data to try to figure it out.
Engineered immune cells target broad range of pediatric solid tumors in mice
In mouse studies, a Stanford-led team has developed an engineered immune cell that eliminates several types of childhood tumors. The study includes senior author, Crystal Mackall, MD, professor of pediatrics and of medicine, and several authors who are members of the MCHRI.
Predicting, preventing preterm births
Each year, 15 million babies worldwide are born prematurely, arriving at least three weeks before their due dates. Stanford’s top obstetricians, neonatologists, geneticists, microbiologists, immunologists, epidemiologists, health policy experts, and bioengineers are working together to help more babies arrive safely.
SPARK helps academic researchers bring new drugs for rare diseases to market
Stanford’s fast-growing drug-development program and MCHRI’s funded partner, SPARK, has given hundreds of academic researchers around the world the training and connections to get their discoveries out of labs and into the hands of doctors and patients. Read the news story and check Stanford Medicine’s summer article about SPARK.
MCHRI creates patient kits for Stanford Children’s Hospital
Over the summer, the MCHRI team learned about the need for art supplies at the Lucile Packard Children's Hospital Stanford, which are provided to patients to use throughout their stay. Through the Champions for Children program, the MCHRI set up an online registry campaign designed to collect materials from within the team and their associated communities.
Neuroimaging studies linked to neurological developmental challenges of extremely preterm infants
Results from the Neuroimaging and Neurodevelopmental Outcomes (NEURO) School Age Follow-Up Study were recently published in Pediatrics. Neonatologist and CHRI Faculty Scholar, Susan Hintz, MD, MS Epi, is the lead author on the paper.
Faculty Scholars lead the way in advancing pediatric cancer cellular therapy program
Pediatric hematologist/oncologists and CHRI Faculty Scholars, Kara Davis, DO, and Norman Lacayo, MD, are leading the way in developing cancer cellular therapy programs at Lucile Packard Children’s Hospital Stanford to help patients, like Jesus Sanchez-Romero, receive life-saving treatments.
CHRI awardees Ricardo Dolmetsch and Sergiu Pasca venture into the emerging field of molecular psychiatry
Neuroscientists Ricardo Dolmetsch, PhD, and Sergiu Pasca, MD, each received funding from the CHRI early on to help support their collaborative and innovative work in understanding the development of human brain disorders.
Faculty Scholar shares experience in the Eureka program for translational medicine
The CHRI sponsored several Stanford faculty, including hematologist/oncologist Anupama Narla, MD, to attend a seven-day course in translational medicine at the Eureka Institute for Translational Medicine in Siracusa, Italy.
The long-term vision in science: Faculty Scholar finds her Eureka moment as a translational scientist
Psychiatrist and behavioral scientist Manpreet Singh, MD, MS, shares her journey as translational researcher and the impact of the multiple awards she has received from the CHRI in her work, including the most recent opportunity to attend an intensive course at the Eureka Institute for Translational Medicine in Siracusa, Italy.
CHRI Faculty Scholars team up to transform the science and treatment of concussion
By Laura Hedli
David Camarillo, PhD and Gerald Grant, MD are among the nation’s foremost concussion experts and teaming up to transform the science and treatment of head injuries. They are CHRI Faculty Scholars and have received several grants towards concussion-specific research efforts.
Transformative Science Requires Risk
By Laura Hedli
Michelle Monje, the Anne T. and Robert M. Bass Endowed Faculty Scholar and recipient of several Child Health Research Institute grants, takes a dynamic approach to studying brain tumor growth and potential treatments.
Building successful futures: CHRI Transdisciplinary Initiatives Program awardee investigates the health of immigrant families and children
By Laura Hedli
Fernando Mendoza, a professor of pediatrics and the primary investigator on a CHRI Transdisciplinary Initiatives Program (TIP) grant, explores the health and well-being of children in immigrant families in California, as well as the impact of federal, state, and local policies on health outcomes.
Older fathers associated with increased birth risks
A decade of data documenting live births in the U.S. links babies of older fathers with a variety of increased risks at birth according to a new study. Michael Eisenberg, MD, associate professor of urology and MCHRI member, is the senior author of the study.
5 Questions: What parents should know about poliolike illness
Small clusters of cases of infectious paralysis are occurring in young children across North America. Pediatric neurologist and MCHRI member, Keith Van Haren, MD is working to understand the disease.
‘DNA origami’ triggers tissue generation in early development
In trying to decipher the “DNA origami” responsible for the generation of transplantable human skin, Stanford researchers have uncovered a master regulatory hierarchy controlling tissue differentiation. Anthony Oro MD, PhD, professor of dermatology, is senior author of the study.
5 Questions: Progress in peanut-allergy immunotherapy
As immunotherapy for peanut allergy advances, Sharon Chinthrajah, MD, clinical associate professor of medicine and of pediatrics discusses what that means for parents, providers and the future of allergy treatments.
Home videos of children can be scored to diagnose autism
Short home videos can be used to diagnose autism in children, according to a new Stanford study. MCHRI awardee, Dennis Wall, PhD, associate professor of pediatrics and of biomedical data science is the senior author.
Understanding the link between preeclampsia and heart disease later in life
Mark Hlatky, professor of medicine and of health research and policy, Virginia Winn, MD, PhD, associate professor of obstetrics and gynecology and MCHRI Faculty Scholar, will lead an interdisciplinary study of the links.
‘Chemo brain’ caused by malfunction in three types of brain cells
Three types of cells in the brain’s white matter show interwoven problems during the cognitive dysfunction that follows treatment with the cancer drug methotrexate, Stanford neuroscientists have found. Michelle Monje, associate professor of neurology and neurological sciences, is the senior author and an MCHRI Faculty Scholar.
CHRI Funds Six Biodesign Faculty Fellows
The CHRI has funded six Biodesign Faculty Fellows for fiscal year 2019. The Institute partners with the Stanford Biodesign Faculty Fellowship program to support motivated Stanford faculty members with advanced training and mentoring in health technology innovations and fund maternal and child health projects.
Turning molecules into medicine with SPARK
An article in Stanford Medicine magazine profiles SPARK, an international program founded at Stanford that provides training and connections to help turn lab discoveries into treatments. CHRI partners with SPARK to fund projects related to maternal and child health research.
Concussion researchers study head motion in high school football hits
A research team led by concussion experts and CHRI members, David Camarillo, PhD, and Gerald Grant, MD, is outfitting the players with mouthguards that measure the motion of the head during impacts sustained in practices and games.
Eight scientists awarded NIH grants for high-risk, high-reward research
Eight School of Medicine researchers, including several CHRI members and awardees, will receive $32 million over five years to fund explorations of cancer, the brain, the aging process, chromosomes and the development of cells.
CHRI Announcement: Funding Increase for the Postdoctoral Support Program FY 2019
The CHRI is pleased to announce an increase in funding through its Postdoctoral Support Program to match the campus-wide minimum for postdoctoral fellows.
Lucile Packard Children’s Hospital Stanford among the nation’s best pediatric hospitals
U.S. News & World Report once again ranks Lucile Packard Children’s Hospital Stanford among the nation’s best pediatric hospitals for the 14th consecutive year.
CHRI awards $800K to four Transdisciplinary Disciplinary Initiative Projects in 2018
The CHRI awards a total of $800,000 to four Transdisciplinary Disciplinary Initiative research projects led by teams from different schools to work together on innovative projects with significant impact in maternal and child health. Read more.
CHRI awards $3.3.M to 44 clinical fellows, postdocs, and master’s students in 2018
The CHRI awards a total of $3,364,982 to 26 clinical trainees, 14 postdoctoral researchers, and 4 master’s students who are pursuing clinical and translational research in maternal and child health. Read more.
CHRI awards over half a million dollars to 16 Pilot Grants in 2018
The CHRI awards a total of $541,026 to 16 pilot grants in three categories: Early Career Pilot grants for instructors and assistant professors, New Ideas grants for mid to senior investigators, and Clinician Educators grants for clinical instructors or above. Read more.
Inaugural research symposium set for November 16
The inaugural CHRI Symposium, scheduled for Friday, November 16th at the Stanford University Li Ka Shing Center for Learning & Knowledge, will highlight the latest developments in maternal child health research from across the campus. Registration is now open.
CHRI Announcement: New funding opportunity for instructors on NIH K-awards
The Instructor K Award Support provides supplemental support for instructors who pursue an NIH K-award. The CHRI will match departmental commitments of up to $25,000 per year, providing a total combined CHRI/departmental support of up to $50,000 per year for up to two years.
Scientists find possible autism biomarker in cerebrospinal fluid
In a recent study, Stanford scientists have found low levels of a hormone called vasopressin that are linked to low social ability in monkeys and to autism in children. CHRI awardee, Karen Parker, PhD, is the lead author of this study.
Brain scans yield more clues to autism
Children with autism have structural and functional abnormalities in the brain circuit that normally makes social interaction feel rewarding, according to a recent study. Vinod Menon, PhD, professor of psychiatry and behavioral sciences, is the senior author.
Google Glass helps kids with autism read facial expressions
Children with autism were able to improve their social skills by using a smartphone app paired with Google Glasses, according to a study led by senior author and CHRI member, Dennis Wall, PhD, associate professor of pediatrics and of biomedical data science.
Rosenkranz Prize winner hopes to develop malaria vaccine for pregnant women
Prasanna Jagannathan, MD, assistant professor of medicine, received the 2018 Rosenkranz Prize, which he hopes to use to develop a malaria vaccine for pregnant women. He received a CHRI award for his pilot work on malaria chemoprevention in pregnancy and transfer of antimalarial antibodies to newborns.
New CEO of Lucile Packard Foundation for Children’s Health appointed
Cynthia Brandt Stover has been appointed president and CEO of the Lucile Packard Foundation for Children’s Health. The foundation directs all fundraising for the Stanford Children’s Hospital and for the maternal and child health programs at the School of Medicine.
Stanford study shows how head and neck positioning affects concussion risk
Stanford researchers are working with a model they developed in David Camarillo’s lab to stimulate how head and neck positioning during an impact affects rotational acceleration resulting from the impact.
A closer look at the powerhouses of the cell, mitochondria
Daniel Bernstein, MD, the Alfred Woodley Salter and Mabel G. Salter Endowed Professor, recently gave a lecture at the CHRI Seminar Series on an imaging technique for assessing the diversity of mitochondria.
How Stanford research is making MRI scans safer for kids
Shreyas Vasanawala, professor of radiology, is tailoring MRI equipment to children. In this Q&A, he discusses how his work allows young patients to receive faster MRI exams that require less anesthesia.
Stanford Medicine honors Christopher Dawes, a transformational leader
The longtime CEO of Lucile Packard Children’s Hospital Stanford, Christopher Dawes, has retired after nearly three decades of shaping health care for children and expectant mothers.
How blood will soon tell us everything
Recent studies show you can predict a woman’s due date within a two-week window from a blood test. Bill Gates highlights the work of Stephen Quake, a professor of bioengineering and of applied physics, and how noninvasive blood tests are the future of health care.
The new, improved world of infant care
Six research centers are finding new ways to prevent premature birth, which affects one in 10 infants and can cause serious and costly mental and physical disabilities.
Blood test might predict pregnancy due date and preterm birth
A Stanford-led team has developed a blood test that can give a reliable estimate of the baby’s due date and can predict if the baby will arrive prematurely. Study included co-senior author Stephen Quake, PhD, a professor of bioengineering and of applied physics.
Ms. Hosna Omarzad receives Donna Schurr Spirit Award
The CHRI is proud to announce Ms. Hosna Omarzad as the recipient of the 2018 Donna Schurr Spirit Award, given by the Department of Pediatrics at the Stanford School of Medicine for an outstanding staff member for their outstanding performance and dedication.
Genetic variation in progesterone receptor tied to prematurity risk
Humans have unexpectedly high genetic variation in the receptor for a key pregnancy-maintaining hormone, according to research led by Stanford scientist. Gary Shaw, DrPH, and David Stevenson, MD, both professors of pediatrics, share senior authorship of this study.
Separation from parents removes children’s most important protection
Stanford psychologist Ian H. Gotlib discusses the psychological effects of early-life stress and parental separation. Gotlib’s research has shown that children need their parents for their own emotional well-being.
A rare disease inspires a Stanford team to develop a new test
Fanconi anemia is a rare but deadly disease and there are no good drugs to treat its root cause, but Stanford researchers, including Eric Kool, PhD, and Kenneth Weinberg, MD, and collaborator Daria Mochly-Rosen, PhD, are developing a test that could help kids with the disease.
Dr. Yvonne Maldonado celebrated for her accomplishments in pediatric research
Yvonne Maldonado, MD, senior associate dean for faculty development and diversity and professor of pediatrics, is celebrated for her perseverance and accomplishments in pediatric research.
Dr. Crystal Mackall awarded $11.9M for anti-leukemia clinical trial
Crystal Mackall, professor of pediatrics and of medicine at the School of Medicine, was awarded $11.9 million by the California Institute for Regenerative Medicine(CIRM) to fund a anti-leukemia clinical trial.
New Precision Health and Integrated Diagnostics Center sets out to stop disease before it starts
Officially established last year, the Stanford Precision Health and Integrated Diagnostics Center brings together scientists from across campus to focus on precision health and integrated diagnostics. The center’s team of scientists includes members from the CHRI.
Health Innovation Opportunities for 2017-2018 Stanford Biodesign Faculty Fellows
The Stanford Biodesign Faculty Fellowship provides motivated Stanford University faculty members from the schools of Medicine and Engineering with advanced training and mentoring in health technology innovation. Six participants were partially funded by the CHRI.
Link between birth weight and adult metabolic health
New research examines the relationships between birth weight and metabolic and cardiovascular disease in adults. Thomas Robinson, MD, MPH, an expert in childhood obesity and a CHRI executive committee member, provides his take in the article.
Researchers team up to develop new life-saving antibiotics that will not cause deafness in children
Anthony Ricci, PhD, a professor of otolaryngology, and Alan Cheng, MD, an associate professor of otolaryngology, are developing new life-saving antibiotics that will not cause deafness in children. This project was supported by SPARK, funded in part by the CHRI for projects focused in maternal and child health. See article in Stanford Medicine magazine and blog post in Scope.
Countdown to Childx: Bioethics in pediatrics
The Childx conference, a TED-style event happening next week at Stanford, will feature a keynote session by bioethicist Jeffrey Kahn, PhD, director of the Johns Hopkins Berman Institute of Bioethics.
Stanford Childx 2018: Big ideas for little patients
Highlights from Childx, a cross-disciplinary science, medicine, public policy and healthcare symposium on research developments and opportunities for improving pediatric care.
Dr. Mary Leonard Receives Silicon Valley Tribute to Women Award
Mary Leonard, MD, MSCE, executive director of the CHRI, has been selected as one of the recipients of the 2018 YWCA Silicon Valley Tribute to Women. She is honored for her significant contributions to the Silicon Valley through their leadership in medicine and health care.
Altered immune cells clear childhood brain tumor in mice
Recent study published in Nature Medicine demonstrates the first time a severe brainstem cancer has been eradicated in mice with the tumor. The senior authors are CHRI members, Michelle Monje, MD, PhD and Crystal Mackall, MD.
Precision health and growth mindsets at Childx
The third Childx conference was held last week at Stanford, hosted by the Child Health Research Institute. Hundreds of pediatricians, educators, scientists and policy experts attended the TED-style event to address challenges and solutions in child health.
Using big data to understand the disappearing American dream at Childx
Stanford economist Raj Chetty, PhD, delivers his keynote session at last week's Childx conference on the American dream of children growing up to earn more than their parents is harder to achieve than it used to be.
Tackling childhood obesity at Childx
Speakers at Childx, including Stanford Medicine pediatrician Tom Robinson, MD, explore novel approaches to tackling the challenging issues in childhood obesity.
Stanford’s Childx conference starts today. Jump in!
Today marks the start of Stanford's third Childx conference, a TED-style event addressing challenges and solutions in child health.
Upcoming Childx conference will highlight collaborative solutions in child health
Next month, experts from many fields will convene at Stanford's third Childx conference to discuss challenges and solutions in child health. Heidi Feldman, MD and David Cornfield, MD, co-chairs of the conference share insights on this year's event.
The complex nature of concussion
A recent report in Physical Review Letters look at the complex nature of concussion, led by a team working under David Camarillo, PhD, an assistant professor of bioengineering and a member of the CHRI.
Countdown to Childx: What doctors can do to improve health literacy
Health literacy means doctors explaining health care tasks - such as giving a child medication - in doable steps that don’t make you feel like you’re overwhelmed, says health-literacy expert Ruth Parker, a guest at next month's Childx conference.
Countdown to Childx: Medical device innovation for kids with chronic disease
Pediatric cardiologist and biomedical innovator Bronwyn Harris talks about the challenge of translating data into better outcomes for kids with chronic diseases. Dr. Harris will speak at the upcoming Childx conference.
Recent study suggest that pediatric obesity and depression are connected in the brain
Early-life obesity and depression may be driven by shared abnormalities in brain regions that process rewards, according to a recent study with lead authorship by Manpreet Singh, MD, assistant professor of psychiatry and behavioral sciences and a member of the CHRI.
Innovative ideas and research at the Stanford 2018 Childx
Over 30 speakers from bioengineering to psychology took the stage at the third Childx conference earlier this month on Stanford campus and delivered the latest developments and advancements in children’s health.
Stanford team tests sleep monitoring for asthma patients
Pediatric pulmonologist and CHRI member, David Cornfield, MD and a group of colleagues are testing a new monitoring approach that uses data collected during sleep.
CHRI Funds Two Diabetes Research Center Seed Grants
The CHRI funded two Stanford Diabetes Research Center (SDRC) Pilot and Feasibility seed grants, one to Eric A. Appel, PhD and the other to H. Tom Soh, PhD, in support of maternal child health related research.
CHRI Introduces New Seminar Series
The Stanford Child Health Research Institute will officially launch a new seminar series starting March, highlighting current research and the latest developments in maternal child health.
The secret to building a strong heart lies in blood vessels
A recent study has linked a cardiovascular disease to poorly developed blood vessels around the heart in babies. The study included author Joseph Wu, MD, the Simon H. Stertzer professor of cardiovascular medicine, who has served as a mentor and co-investigator on several CHRI-funded awards.
Daniel Bernstein Named Associate Dean for Curriculum and Student Scholarship
Daniel Bernstein, MD, the Alfred Woodley Salter and Mabel G. Salter Professor of Pediatrics, has been appointed as the School of Medicine’s Associate Dean for Curriculum and Student Scholarship. He serves as the co-chair of the Clinical Trainee Support funding program in the CHRI.
CHRI Funds Two Global Child Health Equity Seed Grants
The CHRI funded two Global Child Health Equity Seed Grants of $25,000 each to Jennifer Keller, PhD and Clea Sarnquist, DrPH, MPHM for projects seeking solutions to improve the health of pregnant women and children in low-resource settings.
Awardees Selected for Bridge Funding Support Progam
The CHRI awarded two Bridge Funding Support, one to Manisha Desai, PhD, and the other to Julie Parsonnet, MD, to aid in the continuation of their research projects in maternal child health.
Taube's Gift to Launch Youth Addition, Children’s Concussion Initiatives
The Taube’s combined gift of $14.5M will enable Gerald Grant, MD, associate professor of neurosurgery and David Camarillo, PhD, assistant professor of bioengineering to advance concussion education, care and research. They will speak about this topic at a champions reception the evening before the Childx conference.
CHRI co-sponsors 2nd annual Center for Definitive and Curative Medicine Symposium
With the support of the CHRI and the Lucile Packard Children's Hospital Stanford, the Center for Definitive and Curative Medicine Symposium put on this year’s annual scientific conference.
Recent deployment linked to higher risk of premature delivery
Giving birth soon after military deployment is linked to greater risk of premature delivery, according to a study of U.S. servicewomen led by author Jonathan Shaw, MD, a member of the CHRI.
Researchers identify renegade cells that spur relapse in children with leukemia
Stanford researchers have published a paper in Nature Medicine that describes a technique to determine at diagnosis whether children with acute lymphoblastic leukemia would relapse. Authors included CHRI members Kara Davis, DO; Norman Lacayo, MD; Robert Tibshirani, PhD; Garry Nolan, PhD.
Dr. Crystal Mackall wins national award for cancer research
Crystal Mackall, MD and her co-investigators won a 2018 Top 10 Clinical Research Achievement Award for their research in pediatric cancer. Dr. Mackall is a member of the CHRI and recently spoke at the inaugural education seminar.
Sergiu P. Pasca, MD has figured out how to grow brain-like blobs in lab dishes, which could give insights into the biology of neuropsychiatric diseases like autism and aid in the understanding of fetal brain development in other neurodevelopmental disorders.
Dr. Gary Shaw appointed to endowed position
Gary Shaw, DrPH, professor of pediatrics, has been appointed to an endowed position in the School of Medicine. Dr. Shaw is a CHRI member and serves as a panel chair on one of the Institute's funding programs.
David K. Stevenson Elected to the American Association for the Advancement of Science
David K. Stevenson, the Harold K. Faber Professor of Pediatrics and Co-Director of the Child Health Research Institute, was selected to the American Association for the Advancement of Science for his contributions in the field of neonatology and pediatrics.
The New Lucile Packard Children’s Hospital Stanford
The Lucile Packard Children’s Hospital Stanford opened its new main building and grounds on December 9. Designed to transform the patient and family experience, the new 521,000-square-foot building more than doubles the size of the existing pediatric and obstetric hospital campus.
Weight Gain Impact on Cardiovascular System
Stanford scientists have discovered how gaining weight changes your whole body, as described in a recent paper published online in Cell Systems. Senior authorship is shared by Michael Snyder, PhD, professor of genetics and co-investigator on a Stanford Cardiovascular Institute (CVI) seed grant sponsored by the CHRI; and Tracey McLaughlin, MD, professor of medicine, also a recipient of a CVI award funded by the CHRI.
Drug increases speed, safety of treatment for multiple food allergies
Kari Nadeau, MD, PhD, professor of medicine and of pediatrics and the director of the Sean N. Parker Center for Allergy and Asthma Research, is the co-author of this study where they looked at an asthma medication to treat children for food allergies.
California Stem Cell Agency Awards $5.6M in Grants to Anthony Oro
The California Institute for Regenerative Medicine awarded Anthony Oro, professor of dermatology and co-director of the CHRI, $5.6 million to support his work in developing new treatments for children with a blistering skin disease.
Higher blood sugar in early pregnancy raises baby’s heart-defect risk
The study’s senior author, James Priest, MD, assistant professor of pediatric cardiology and recipient of a CHRI sponsored Cardiovascular Institute (CVI) seed grant award, looks at the link between high blood sugar in early pregnancies and baby's risk for heart defects.
High-tech imaging could reveal mysteries of bone damage in kids with chronic disease
Mary Leonard, MD, professor and chair in the Department of Pediatrics at Stanford and the executive director of the CHRI, works to understand exactly how chronic diseases hurt children’s bone health.
Interview with Carol S. Dweck on Growth Mindset
The Times Higher Education recently interviewed Carol S. Dweck, a Lewis and Virginia Eaton professor of psychology, on students’ growth mindset. She is one of the keynote speakers for CHRI's upcoming sponsored event, the 2018 Childx Symposium.
The Future of Genome Editing in Human Diseases
Matthew Porteus, an associate professor of pediatrics and a CHRI-funded investigator, spoke before a U.S. Senate committee for hearing on “Gene Editing Technology: Innovation and Impact.” Also present at the hearing was Jeffrey Kahn, the Director of the Johns Hopkins Berman Institute of Bioethics and a keynote speaker for CHRI-sponsored 2018 Childx Symposium.
Publication: Macrophage-released ADAMTS1 Promotes Muscle Stem Cell Activation
Nature Communications released a recent publication on a study, funded in part by the Child Health Research Institute, that examined how hormones play a role in muscle stem cells activation and the implications for muscle growth and regeneration. The team of Stanford researchers behind this study included Brian Feldman, an assistant professor of pediatrics and a CHRI-endowed Bechtel Faculty Scholar.
**NEW** CHRI Funds Global Child Health Seed Grants
The CHRI-sponsored Global Child Health Equity (GCHE) Seed Grant program aims to support two global health seed grants of up to $25,000 each for projects seeking solutions to improve the health of pregnant women and children in low-resource settings. Deadline for proposal submission has been extended to December 15, 2017.
Children of War
Paul Wise, a professor of pediatrics and core faculty member of the Stanford Center for Health Policy, is working with colleagues to address the needs of children in areas of unstable governance and civil war.
CHRI Funds 2018 Biodesign Faculty Fellowships
As of Fiscal Year 2018, Child Health Research Institute (CHRI) will fund 50% for maternal child health Biodesign Faculty Fellowships. The fellowship provides motivated Stanford faculty members from the schools of Medicine and Engineering with advanced training and mentoring in health technology innovation.
Anthony Oro Named Co-Director of the Child Health Research Institute
The Stanford Child Health Research Institute is proud to announce a new Co-Director, Anthony Oro, MD, PhD, the Eugene and Gloria Bauer Professor in the Department of Dermatology.
Use big data
Sociologist Karen Cook and other Stanford researchers are encouraging their colleagues who study social interaction to conduct studies that examine online environments and use big data.
David Schneider appointed chair of microbiology and immunology
David Schneider, whose research focuses on resilience to infection and developing mathematical models to predict recovery and well-being, succeeds Peter Sarnow in post.
Virtual Reality imaging technology gives surgeons a better view into patient anatomy
Radiologists and surgeons at Lucile Packard Children’s Hospital Stanford are using new technology to generate easily manipulated 3-D images of patients’ anatomy from flat CT and MRI scans.
The Virtual Heart
Stanford's David M. Axelrod, MD, and David A. Sarno of Lighthaus present at the CeBIT Global Conferences.
Finding the cures within us
Stem cell research holds the promise of a sea change in medicine. At Stanford, momentum is building.
American Society of Gene and Cell Therapy Awards Maria Grazia Roncarolo 2017 Outstanding Achievement Award
Roncarolo is being recognized for her many contributions to the field of gene and cell therapy, which she will describe in an award lecture on Friday, May 12 in Washington, DC as part of the organization’s annual meeting.
Child Health Research Institute awards 26 grants for 2017
The Stanford institute’s grant program funds projects that support innovative clinical and translational research on maternal and child health.
Gene therapy for blistering skin disease appears to enhance healing in clinical trial
A trial in which genetically altered skin was grafted onto patients’ chronic wounds marks the first time that skin-based gene therapy has been demonstrated to be safe and effective in humans.
5 Questions: Halpern-Felsher on teens’ misconceptions about marijuana
A survey of hundreds of California high-school students shows that teens don’t understand the risks of marijuana use, and are more likely to smoke it if they have seen marijuana ads.
Researchers take step toward gene therapy for sickle cell disease
Using the CRISPR gene-editing technique in stem cells, Stanford researchers repaired the gene that causes sickle cell disease, and the mended stem cells were successfully transplanted into mice.
Traumatic stress changes brains of boys, girls differently
A brain region that integrates emotions and actions appears to undergo accelerated maturation in adolescent girls with PTSD, but not in boys with the condition, a Stanford study has found.
Stanford patient was first to receive lifesaving drug as an infant
Four-year-old Zoe Harting is doing well after participating in a phase-2 clinical trial of the first drug for a deadly genetic disease, spinal muscular atrophy type 1.
What Happened Within This Player’s Skull
Information from mouth guard sensors, developed by bioengineer David Camarillo and his team at the Cam Lab, provide a more detailed and precise window into what was happening within a football player’s brain within milliseconds after a hit.
Stanford researchers expand comparison of males and females with anorexia
Recently, a team of researchers from Stanford and other universities have published a series of papers to help fill this knowledge gap.
Conjoined twins successfully separated at Packard Children’s Hospital
Two-year-old twin sisters Erika and Eva Sandoval are recovering in the pediatric intensive care unit following their Dec. 6 separation surgery.