Additional Ventures Innovation Fund Single Ventricle Disease Research Program

LETTER OF INTENT DEADLINE: January 13, 2020 - 5:00 p.m.

*Deadline extended*
FULL PROPOSAL (by invitation) DEADLINE: April 8, 2020 - 5:00 p.m.

The Stanford Maternal and Child Health Research Institute (MCHRI) Additional Ventures Single Ventricle Innovation Research Program aims to promote truly innovative research to treat and functionally cure single ventricle heart disease. This program will support a wide range of scientific approaches from basic, clinical, translational, engineering, information and other biomedical sciences to better understand the root causes of SVDs and to develop functional cures for those living with this condition.

The goal of each Additional Ventures Innovation Funds is to spark innovative and unique research ideas, to engage new members into the single ventricle and Fontan community, and to accelerate progress towards 1) understanding the underlying etiology of single ventricle heart defects and 2) developing functional cures for SVDS or for those with the Fontan circulation. We strongly encourage faculty from different schools to work together on these initiatives, and strongly promote collaborations between basic and physician scientists. High-risk/high-reward single-ventricle project ideas that are novel or take a novel approach will be prioritized for this seed-funding opportunity.

A multi-PI approach is strongly encouraged for this initiative where at least two of these lead investigators are from different disciplines and schools, however, single-PI applications will be considered if the scientific rationale is compelling. This program will fund cutting edge projects in the following categories: (1) basic science; (2) bioengineering; (3) genetics/genomics; (4) translational medicine; (5) interventional cardiology/radiology; (6) cardiac surgery; (7) clinical research/population science; (8) bioinformatics/analytics

Forms for Applicants

Letter of Intent Application Guidelines

*Submit your letter of intent (LOI) to with “Additional Ventures Innovation Fund” in the email subject line. You do not need to submit your LOI via your RPM.


Applicants will be notified to proceed with full proposals by February 1st and selected applicants will be invited to give a 10 min lay audience presentation to the donor and SAB in March 2020.

Full Proposal (by invitation) Deadline: April 8, 2020 - 5:00 pm (Deadline extended)

Notification of selected proposals: Late May 2020

The project start date is no later than July 1, 2020 and the performance period is 12 to 24 months.


  • All Stanford faculty holding Clinician Educator (CE), University Tenure Line (UTL), Research (NTL-Research), or Medical Center line (MCL) positions, graduate students, residents, post-doctoral fellows, and clinical residents and fellows at a Stanford hospital.
  • Recommended, but not required: Utilize a multi-PI approach where at least two of the principal investigators are from two different disciplines and hold primary appointments in two different schools of the university (Medical School, Bioengineering, Graduate School of Business, Earth, Energy & Environmental Sciences, Education, Humanities & Sciences, Law and Medicine).


Total seed funding award is up to $300,000 / year for 12-24 months. Support could be for personnel (undergraduate, graduate, or postdoctoral students, research assistants, or associates, or faculty) and additional research related expenses. Promising projects may be eligible for follow-on funding to a point where they are primed for external funding opportunities.


Please contact MCHRI Administration or 650-724-0279 with any questions.