Xianlan Wen (Wen)
Voltage-gated Cl– channels (“CLC-2” channels) are expressed in almost every neuron in the brain, but we know little about how they contribute to neuronal excitability. I am interested in the improving our understanding of CLC-2’s function in the brain. To do so, I am taking advantage of a new small-molecule CLC-2 inhibitor, AK-42, developed by graduate student Anna Koster.
AK-42 is by far the most potent and selective CLC inhibitor known, with an IC50 of 17 nM for CLC-2 and >10,000-less potency towards CLC-1. I contributed to our understanding of AK-42’s mechanism of action by performing mutagenesis and electrophysiology experiments to test our lab’s computational-docking predictions (Koster et al., 2020).
Currently, I am studying the function of CLC-2 in brain-slice tissue. Since CLC-2 has been hypothesized to influence generalized epilepsy, I am studying its role in inhibitory reticular thalamus (RT) neurons and excitatory thalamocortical relay (TC) neurons. The intra-thalamic oscillation between these neurons is a well-established system for studying epilepsy.
Favorite movie: The Notebook
Hometown: Yanbian, China
Hobby: Reading Psychology books
Favorite Wu-Tang Member: Huh?
Contact: gusfks at stanford dot edu