The Maduke Lab
The Maduke laboratory studies the molecular mechanisms of ion channels and transporters, with a focus on the CLC Family of proteins. These gradients are fundamental for a variety of physiological processes, including energy production, cell signaling, and maintaining osmotic balance. Our lab uses a combination of biophysical methods to investigate membrane-protein structure and dynamics together with electrophysiological analyses to directly measure function to determine the molecular mechanisms of these proteins.