Current Projects
Discovery of pathogenic smooth muscle cell response pathways to environmental exposures
Our lab investigates how vascular smooth muscle cells (SMCs) respond to environmental pollutants (such as dioxin, PM2.5, nanoplastics), identifying specific molecular pathways that contribute to disease progression. By exploring how toxins and pollutants alter SMC phenotype and promote inflammation, we aim to uncover new insights into the cellular mechanisms driving atherosclerosis and vascular dysfunction. These findings will help identify potential therapeutic targets to mitigate the impact of environmental exposures on cardiovascular health.
The role of the AHR pathway in atherosclerosis development
We focus on the aryl hydrocarbon receptor (AHR) pathway, a key sensor of environmental dioxins, and its role in the development of atherosclerosis. By studying how AHR activation by pollutants influences inflammatory and oxidative stress pathways in vascular cells, we aim to understand its impact on plaque formation and stability. By examining AHR’s dual role in normal function and toxicant response, our research aims to identify pathways that could be targeted to mitigate both endogenous and environmental contributions to vascular disease.
Identifying the pro-atherosclerotic mechanisms induced by exposure to electronic cigarettes
Our lab examines the molecular and cellular effects of tobacco and electronic cigarette (e-cig) exposure on the vasculature, with a focus on its impact on atherosclerosis. Through advanced models and techniques, we analyze how tobacco/e-cig aerosols trigger inflammation, oxidative stress, proteotoxicity, and smooth muscle cell transitions that contribute to plaque development. This research is crucial for understanding the cardiovascular risks posed by tobacco/e-cigarettes and guiding public health policies.
Identification and validation of biomarkers of exposure and cardiovascular disease
We develop and validate biomarkers that accurately reflect environmental exposures and predict cardiovascular disease risk. By combining multi-omics approaches and high-sensitivity detection techniques, our research identifies specific biomarkers that can serve as indicators of exposure to pollutants and early markers of cardiovascular disease. These biomarkers will help improve screening, early detection, and personalized prevention strategies, particularly for populations at high risk due to environmental factors (In collaboration with Francois Haddad, Holden Maeker, Mary Johnson, Ben Horne, Kari Nadeau).
