News & Events

September 2021 – Congratulations to Moy on starting a Translational Scientist 2 position at Codexis. We wish you the very best and will miss you!


August 2021 – Julia receives an Early Career Award from The Carol and Eugene Ludwig Family Foundation. We so appreciate the support!


July 2021 – New collaborative paper published in eNeuro on COUNTEN, an AI-Driven Tool for Rapid and Objective Structural Analyses of the Enteric Nervous System. Congratulations to all authors!


July 2021 – Great conversations with Subhash Kulkarni during his trip to the bay area! Looking forward to more collaborations.


June 2021 – Julia becomes the next Firmenich Next Generation Faculty Scholar! Super honor!


June 2021 – New review published in Current Opinion in Physiology on Proprioception revisited: where do we stand?. Congratulations to Jen and Julieta!


May 2021 – Congratulations to Keira on passing her qualifying exam!


May 2021 – Ryan wins First Place Poster Award at Gastronauts Global 2021 for his poster  “A bird’s eye view of the mouse myenteric plexus”. Congratulations Ryan!


April 2021 – Julia gives a seminar on “Mapping the “second brain”: development and organization of the enteric nervous system” as part of the Stanford Medicine Basic Science Faculty Retreat.


March 2021 – Keira receives an Honorable Mention on her NSF application!


March 2021 – Julia gives a seminar on “Mapping the “second brain”: development and organization of the enteric nervous system” as part of the Stanford Regenerative Medicine Seminar Series.


February 2021 – Julia gives a zoom seminar on “Understanding neuronal circuitry underlying locomotion and gut motility” at the Florey Institute of Neuroscience & Mental Health in Parkville, Australia. Thank you, Marlene Hao, Snezana Maljevic and Daniel Scott, for being amazing hosts!

February 2021 – New collaborative paper published in Nature Neuroscience on Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons. Congratulations to all authors! Check out the cool front cover!


January/February 2021 – Julia and Sergio teach Neurosciences Development Core NEPR.


January 2021 – Julia gets nominated for the NINDS Landis Mentoring Award. A big thank you to my current and former mentees!!


December 2020 – Secret Santa zoom party!


October 2020 – Lab Fall FunFest!


October 2020 – Julia gives a seminar on “Interneuron circuitry in the spinal cord” as part of the 13th Annual Society for Neuroscience Satellite Symposium on Motor Systems; Washington, DC (zoom Seminar)


October 2020 – Julia becomes Basic Science Diversity Liaison for the Neurosciences PhD Program.


August 2020 – Congratulations to Lori on passing her qualifying exam!


August 2020 – Gabrielle Barsh joins the lab as a PGY-2 Pediatric Neurology Resident. Welcome Gabby!


August 2020 – Josh joins the Krasnow lab and will be co-advised by Julia.


July 2020 – Keira joins the lab.


July 2020 – A collaborative NIH grant with Chet Moritz (UW) and Polina Anikeeva (MIT) got funded. Looking forward to working together on improving hand function after spinal cord injury. Thanks for having us on the team and thank you to the NIH for their support!


June 2020 – Emily Trimm, MSTP student from the MD-PhD program, starts her rotation in the lab. Welcome Millie!


June 2020 – Julieta gives a talk on “Uninterrupted messaging: Evidence for direct spinal cord control of the colon” at the Chemistry/Biology Interface Training Program Retreat.


June 2020 – Congratulations on graduating, Amara! We wish you all the best for your new endeavors at Johns Hopkins.


April 2020 – Cole Hansen joins the lab as a Life Science Research Professional. Welcome Cole!


March 2020 – The Kaltschmidt lab is ZOOMing!


March 2020 – Julia gives a seminar on “Understanding neural circuitry underlying locomotion and gut motility” as part of the Rutgers University Women in Neuroscience series at Rutgers University. Thank you, Nishtha Trivedi, for organizing my amazing day. Great way to celebrate International Women’s Day!


March 2020 – Julia gives a seminar on “Walk, eat, mate: the motor circuits” as part of the Gastronauts Series at Duke University. Thank you to Diego and everyone in the Bohórquez Lab for being wonderful hosts!


February 2020 – Beatriz gets selected as a Bertarelli Fellow for the 2019-20 academic year. Congratulations Beatriz!


February 2020 – Ryan gives a seminar on “Glutamate and organizational features of the enteric nervous system” at The Stanford Center for Molecular Neuroscience in Health and Disease.


February 2020 – Julia receives a gift from the Shurl & Kay Curci Foundation for “Understanding Neuronal Circuitry Underlying Gut Motility”. We so appreciate the support!


January/February 2020 – Julia and Sergio teach Neurosciences Development Core NEPR 202.


January 2020 – Songnan Wang, Berg Scholar from the MD program, starts her rotation in the lab. Welcome Songnan!


January 2020 – Julia gives a seminar on “Understanding neuronal circuitry underlying gut motility” at the Stanford-EPFL Neuroscience Symposium in Lausanne, Switzerland. Thank you, Carmen Sandi and Pavan Ramdya, for being amazing hosts!


January 2020 – Our lab moves to the Stanford Neurosciences Building. Very excited to share an open lab space with the Brunet and Wyss-Coray labs!


January 2020 – We say good-bye to the Clark Center, our lab’s home for the last two and a half years. What a great environment to start out at Stanford.


December 2019 – Lab holiday party.


September 2019 – The Kaltschmidt lab is on Twitter! https://twitter.com/kaltschmidt_lab


September 2019 – Keira Robertson and Joshua Head, Ph.D. students from the Neurosciences Program, start their rotations in the lab. Welcome Keira and Josh!


September 2019 – Jennifer Shadrach starts her postdoc in the lab. Welcome Jen!


September 2019 – New review published in Neural Development on Commissural axon guidance in the developing spinal cord: from Cajal to the present day. Congratulations to all authors!


 September 2019 – Janelle joins the Tawfik lab and will be co-advised by Julia.


September 2019 – Julia gives a seminar on “Understanding neuronal circuitry underlying gut motility” as part of the Developing Brains symposium at the Karolinska Institute in Stockholm, Sweden.


September 2019 – Julia gives a lecture on “Molecular basis of neuronal circuit formation” as part of the The Developing Brain course at the Karolinska Institute in Stockholm, Sweden. Thank you, Ulrika Marklund, for being such an amazing host!


July 2019 – We say good-bye to Anna and wish her the best of luck for all her new endeavors!


July 2019 – Julia gives a seminar on “Understanding neuronal circuitry underlying gut motility” at the UCSF Program in Craniofacial Biology Retreat at the California Academy of Sciences. Thank you, Licia Selleri, Ralph Marcucio and Ophir Klein, for the invitation – what a wonderful retreat!


July 2019 – Beatriz and Julia attend 6th Global NGLY1 Conference hosted by Grace Science Foundation in Palo Alto.


July 2019 – Summer lab bbq.


July 2019 – Cac Tran joins the lab as a Life Science Research Professional. Welcome Cac!


July 2019 – Congratulations to Beatriz on passing her qualifying exam!


June 2019 – Julieta wins Best Poster Award at the Chemistry/Biology Interface Training Program Retreat for her poster “Investigating spinal-enteric neural circuitry in the mouse colon”. Congratulations Julieta!


June 2019 – Ryan receives an EMBO Long-Term Fellowship Award to study “Molecular characterisation and functional assessment of glutamatergic cells in the enteric nervous system”. Congratulations Ryan!


May 2019 – We receive funding from the National Institute of Neurological Disorders and Stroke to study “Molecular Mechanisms Regulating Inhibitory Circuitry in the Spinal Cord”. We are very grateful for the support.


May 2019 – Subhamoy presents a poster on “Role of ETV1 in gastrointestinal motility” at the Digestive Diseases Week 2019 annual conference.


April 2019 – New preview published in Neuron on Chandelier Cells Swipe Right for L1CAM. Congratulations Ryan!


March 2019 – Julia gives seminar on “Understanding neural circuitry underlying locomotion and gut motility” at the bonnbrain3 meeting in Bonn, Germany.


March 2019 – Julia gives a seminar on “Understanding neural circuitry underlying locomotion and gut motility” as part of the ChEM-H CBI Seminar Series.


March 2019 – Julia becomes a member of the Stanford Maternal & Child Health Research Institute.


February/March 2019 – Kevin returns to the lab for an AP Internship.


February 2019 – Lori joins the lab.


February 2019 – Janelle Doyle, Ph.D. student from the Neurosciences Program, starts her rotation in the lab. Welcome Janelle!


January/February 2019 – Julia and Sergio teach Neurosciences Development Core NEPR 202.


January 2019 – We receive a gift for our collaborative work with Polina Anikeeva on developing an early enteric marker of Parkinson’s Disease.  We so appreciate the support.


January 2019 – Keri Ngo, Ph.D. student from the Department of Developmental Biology, starts her rotation in the lab. Welcome Keri!


January 2019 – Rahul Shiv joins the lab and wins support from the 2019 Stanford Bio-X Undergraduate Summer Research Program. Congratulations and welcome Rahul!


January 2019 – Julia becomes co-Editor-in-Chief for Neural Development.


December 2018 – Avery Krieger, Ph.D. student from the Neurosciences Program, starts his rotation in the lab. Welcome Avery!


December 2018 – Lab holiday party.


November 2018 – Lori Dershowitz, MSTP student from the MD-PhD program, starts her rotation in the lab. Welcome Lori!


November 2018 – Ryan Hamnett starts his postdoc in the lab. Welcome Ryan!


November 2018 – Julia gives a seminar on “Tuning presynaptic inhibition by retrograde signals and a Contactin/Caspr co-receptor complex” at the 2018 SfN Neuroscience meeting in San Diego. Thank you, Thomas Biederer, for organizing a great “Molecular and Nano-Organization of Synapses” Session.


October 2018 – Amara is selected to present a poster at the 2018 Stanford Symposium of Undergraduate Research and Public Service (SURPS).  Congratulations Amara!


October 2018 – We receive funding from the Grace Science Foundation for characterizing the architecture of the enteric nervous system in Ngly1 mutant mice.  Congratulations Beatriz!


October 2018 – Julia and Ivan teach Responsible Conduct of Neuroscience Research NEPR 212.


September 2018 – Subhamoy gives seminar on “Functional Dissection of ETV1 Circuitry in the Enteric Nervous System” at The Stanford Center for Molecular Neuroscience in Health and Disease.


September 2018 – Congratulations to Julieta on passing her qualifying exam!


September 2018 – Polina Anikeeva, from the MIT Department of Materials Science and Engineering, starts her sabbatical in the lab. Welcome Polina!


September 2018 – Julia gives seminar on “Understanding neural circuitry underlying locomotion and gut motility” at Case Western Reserve University, Cleveland.


September 2018 – Subhamoy gives seminar on “Functional Dissection of ETV1 Circuitry in the Enteric Nervous System” at San Jose State University, San Jose.


September 2018 – New review published in Current Opinion in Neurobiology on Sensory and descending motor circuitry during development and injury. Congratulations to all authors!


August 2018 – Julia becomes a ChEM-H CBI Faculty Mentor.


July 2018 – Summer lab picnic.


July 2018 – Beatriz and Julia attend 5th Global NGLY1 Conference hosted by Grace Science Foundation in Palo Alto.


July 2018 – Subhamoy and Vijaya Kanchustambham from Richard Zare’s lab win Stanford ChEM-H Postdocs at the Interface seed grant. Congratulations Moy and Vijji!


June 2018 – Julia joins the Neurosciences PhD Program as Training Faculty.


June 2018 – Kevin Yang joins lab for a summer internship as a 2018 SIMR Program student. Welcome Kevin!


June 2018 – Michelle Lu joins the lab for a summer internship as a Peddie EXP Program student. Welcome Michelle!


June 2018 – Julia becomes a Faculty Mentor for the Stanford Undergraduate Neuroscience Society (SUNS).


May 2018 – Beatriz, Moy and Julia attend Stanford Neurosciences Institute Retreat in Watsonville.


May 2018 – Julieta and Subhamoy win Beckman Mini-Grant for Image Analysis. Congratulations!


April 2018 – Julieta joins the lab.


April 2018 – Julia gives a seminar on “Understanding neural circuitry underlying locomotion and gut motility” as part of the Stanford Regenerative Medicine Seminar Series.


April 2018 – Julia speaks at Inaugural Symposium for The Stanford Center for Molecular Neuroscience in Health and Disease.


April 2018 – Special Issue on Cellular and molecular mechanisms underlying neural circuit assembly, co-edited by Julia and Tom Clandinin, goes online.


April 2018 – Subhamoy and Julia join Andres and Aida at the ENS Development 2018 Meeting in Boston.


January/February 2018 – Julia and Isabella teach Neurosciences Development Core NEPR 202.


January 2018 – Beatriz joins the lab.


January 2018 – Julieta Gomez-Frittelli, Ph.D. student from the Department of Chemical Engineering/ChEM-H, starts her rotation in the lab. Welcome Julieta!


January 2018 – Amara Aarif, undergraduate student from the Bioengineering Department, joins the lab on a ChEM-H Undergraduate Fellowship Grant. Congratulations and welcome Amara!


December 2017 – Lab holiday party.


December 2017 – Julia gives seminar on “Mechanisms of synaptic specificity underlying interneuronal circuit information” at Emory University School of Medicine, Atlanta.


November 2017– Julia gives seminar on “Mechanisms of interneuronal circuit formation” at University of Oregon, Eugene.


October 2017 – Beatriz Robinson, Ph.D. student from the Neurosciences Program, starts her rotation in the lab. Welcome Beatriz!


October 2017 – New article published in Cell Reports on A role for dystonia-associated genes in spinal GABAergic interneuron circuitry. Congratulations to all authors!


October 2017 – Inaugural ENS joint lab meeting with Linda Nguyen and Aida Habtezion and their lab members.


September 2017 – Julia speaks at Molecular and Cellular Mechanisms of Neural Circuit Assembly EMBO/IST in Klosterneuburg, Austria.


August 2017 – Anna Oppermann joins the lab as a Life Science Research Professional. Welcome Anna!


July 2017 – Subhamoy Das starts his postdoc in the lab. Welcome Moy!


June 2017 – Julia speaks at Inhibition in the CNS Gordon Research Conference in Les Diablerets, Switzerland.


June 2017 – Jarret and Josephine defend their theses. Congratulations Dr. Weinrich and Dr. Belluardo!


May 2017 – Julia speaks at Excitatory Synapses & Brain Function Gordon Research Conference in Les Diablerets, Switzerland.


April 2017 – Julia becomes a Stanford Bio-X affiliate.


April 2017 – Julia moves her lab from New York to Stanford to join the Neurosurgery Department and the Stanford Neurosciences Institute.

Talks

Wiring the nervous system: Interneuron circuitry in the mouse spinal cord

The regulation of information flow by local inhibitory microcircuits has a fundamental role in shaping animal behavior. In the mammalian spinal cord GABAergic inhibitory interneurons serve key functions in sensory-motor transformation. One class of GABAergic interneurons, termed GABApre neurons, forms axo-axonic synapses with the terminals of proprioceptive sensory afferents and exerts an inhibitory constraint on sensory processing. I am using the GABApre interneuron circuitry to understand (i) how distinct neuronal populations are generated, (ii) how these distinct neuronal populations recognize and choose their correct synaptic partners from among different available targets, and (iii) how postsynaptic signals induce the differentiation of presynaptic terminals in service of balanced microcircuit function.

In the future, I expect to maintain a focus on multiple aspects of neuronal circuit biology, including: the intrinsic and extrinsic mechanisms directing synaptic connectivity; the nature and mechanisms of circuit adaptation in health and disease; and the functional organization of GABAergic interneurons in spinal locomotor circuits, sexual response circuitry and the enteric nervous system.

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Department of Neurosurgery

The Kaltschmidt Lab is part of the Department of Neurosurgery.