PET/MR Imaging of Osteoarthritis
OA is characterized by degeneration affecting all tissues in the joint, and an optimal imaging tool to study OA must be sensitive both to bone and soft tissue health. New PET/MR systems allow for simultaneous, sensitive, and quantitative assessments of the whole joint. Magnetic resonance imaging (MRI) provides excellent high-resolution morphologic information of joint tissue along with quantitative metrics of joint soft tissue health. 18F-fluoride PET can be used to study osteoblast activity in subchondral bone and has also been used as a marker of pain while 18F-fluorodeoxyglucose (FDG) PET shows areas of acute phase inflammatory response. We have demonstrated the potential of PET/MR imaging to study pathogenesis in OA.18F-fluoride PET/MR may detect knee abnormalities unseen on MRI alone and is a promising tool for detection of early metabolic changes in OA. Additionally, 18F-FDG PET can provide complementary information about inflammatory processes occurring in the joint. PET/MR thus can simultaneously assess multiple early metabolic and biochemical markers of knee OA progression across all tissues in the joint.
Kogan F, Fan A, McWalter E, Oei E, Quon A, Gold G. PET/MR Imaging of Metabolic Activity in Osteoarthritis: A Feasibility Study. Journal of Magnetic Resonance Imaging. 2016.
Kogan F, Fan A, McWalter E, Quon A, Oei E, Gold G. 18F-Fluoride PET-MR Imaging of Metabolic Bone Activity in Knee Osteoarthritis. Proceedings of the 2016 SNMMI Annual Meeting, San Diego, CA, 2016
Kogan F, Fan A, McWalter E, Oei E, Quon A, Gold G. Correlation of Bone Pathology on MRI with 18F-fluoride PET Uptake in Subchondral Bone. In Proceedings of the 24th International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Singapore, Singapore, 2016.
Kogan F, Fan A, Quon A, Gold G. PET-MR Imaging of Osseous and Inflammatory Metabolic Activity Post Knee Injury. In Proceedings of the 8th International Workshop on Osteoarthritis Imaging (IWOAI), Pacific Grove, CA, 2015.
Kogan F, Fan A, Brazina S, Holley D, Quon A, Gold G. 18F-FDG and 18F-NaF PET/MR Imaging of Osteoarthritis in the Knee: Considerations and Initial Results. In Proceedings of the 23rd International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Toronto, Canada, 2015.
Kogan F, Rosenberg J, Brazina S, Fan A, Holley D, Gold G. Effect of 16-Channel Flex Array Coil on PET Standardized Uptake Values for PET/MR Imaging of the knee. In Proceedings of the 23rd International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Toronto, Canada, 2015.
Merit Award for Highest Scoring Trainee Abstract – International Workshop on OA Imaging - Feliks Kogan (September 2015)
ISMRM Summa Cum Laude Merit Award - Feliks Kogan (June 2015)