Rapid Volumetric MRI of Cartilage GAG Content

MRI is increasingly being used to study and evaluate early osteoarthritis (OA) changes in cartilage biochemical composition.  Detection of changes in cartilage glycosaminoglycan (GAG) content and distribution are vital for early diagnosis of OA and potential treatment monitoring. Chemical exchange saturation transfer imaging of GAG (GagCEST) is a new imaging method which can detect endogenous GAG content in cartilage without the need for invasive contrast injections or special hardware. However, long scan times and low signal-to-noise often limits GagCEST single slice acquisition at ultra-high field (7T) systems. We are developing rapid volumetric GagCEST sequences for whole joint acquisitions on clinical systems (3T). This will provide a clinical tool to sensitively study joint Gag content and enable new insights into OA disease progression and lead to new treatment targets.



Kogan F, Hargreaves B, Gold G. Volumetric Multi-Slice GagCEST Imaging of Articular Cartilage: Optimization & Comparison with T1rho. Magnetic Resonance in Medicine. 2016


Kogan F, Hargreaves B, Gold G. Volumetric GagCEST Imaging: Optimization and Comparison with T1rho. In Proceedings of the 8th International Workshop on Osteoarthritis Imaging (IWOAI), Pacific Grove, CA, 2015.

Kogan F, Hargreaves B, Gold G. Multi-Slice gagCEST Sequence for Whole-Joint gagCEST mapping: Application to Articular Cartilage in the Ankle. In Proceedings of the 23rd International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Toronto, Canada, 2015.