MRI is increasingly being used to study and evaluate early osteoarthritis (OA) changes in cartilage biochemical composition.  Detection of changes in cartilage glycosaminoglycan (GAG) content and distribution are vital for early diagnosis of OA and potential treatment monitoring. Chemical exchange saturation transfer imaging of GAG (GagCEST) is a new imaging method which can detect endogenous GAG content in cartilage without the need for invasive contrast injections or special hardware. However, long scan times and low signal-to-noise often limits GagCEST single slice acquisition at ultra-high field (7T) systems. We are developing rapid volumetric GagCEST sequences for whole joint acquisitions on clinical systems (3T). This will provide a clinical tool to sensitively study joint Gag content and enable new insights into OA disease progression and lead to new treatment targets.