Quantitative 3D Imaging of Cartilage Using the Double-Echo Steady-State (DESS) Sequence
A T2 map (top) and an Apparent Diffusion Coefficient (ADC) map (bottom) in femoral and patellar cartilage of a healthy volunteer. Such maps can help assess tissue structure and aid in early detection of osteoarthritis.
Osteoarthritis (OA) affects tens of millions of US adults at tremendous societal cost. However, development of treatments for OA has been hampered by limitations in detection of early-stage disease. The DESS sequence has shown promise for detecting OA by providing both morphological images as well as quantitative measurements. DESS provides two signals, S1 and S2, before and after a spoiler gradient. These signals provide images that are useful for morphological examination. However, they can also be used for quantitative measurements of the tissue. By scanning under varying settings and comparing the resulting signal levels to theoretical models, T2 and diffusivity can be estimated. Such estimates can help assess tissue structure and aid in early detection of OA.
A fly-through video showing sagittal T2 maps in femoral cartilage of a healthy volunteer. The DESS sequence provides 3D maps, resulting in good detail in the slice direction
People
Bragi Sveinsson, Uche Monu, Akshay Chaudhari, Daehyun Yoon, Marianne Black, Feliks Kogan, Brian Hargreaves, Garry Gold
Emily McWalter, Sungjun Kim, Neal Bangerter, Edwin Oei
Publications
JOURNAL ARTICLES
Staroswiecki E, Granlund KL, Alley MT, Gold GE, and Hargreaves BA. Simultaneous estimation of T2 and apparent diffusion coefficient in human articular cartilage in vivo with a modified three-dimensional Double Echo Steady State (DESS) sequence at 3 T. Magnetic Resonance in Medicine, 67(4):1086–1096, 2012.
CONFERENCE ABSTRACTS
Chaudhari AS, Sveinsson B, McWalter EJ, Gold GE, Hargreaves BA. T2 Relaxometry of Short T2 Tissues in the Knee with High SNR Efficiency. Submitted to the 9th International Workshop on Osteoarthritis Imaging (IWOAI), Oulu, Finland, 2016.
Sveinsson B, Gold G, Hargreaves B. Quantification and Artifact Reduction from Simple Modeling of DESS Signals. In Proceedings of the 24th International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Singapore, Singapore, 2016.
Gold GE, Sveinsson B, Epperson K, Chaudhari A, Alley M, Yoon D, Hargreaves BA, Kogan F. Comparison of DESS T2 Relaxation Times and Apparent Diffusion Coefficient in Articular Cartilage at 3T and 7T. In Proceedings of the 24th International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Singapore, Singapore, 2016.
Chaudhari AS, Sveinsson B, Alley MT, McWalter EJ, Gold GE, Hargreaves BA. Rapid T2 Relaxometry of the Meniscus, Tendons, and Ligaments with an Ultrashort Echo-Time Double-Echo Steady State Sequence. In Proceedings of the 24th International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Singapore, Singapore, 2016.
Sveinsson B, Moran C, Yoon D, Gold G, Hargreaves B. Quantitative Estimation of ADC Using DESS. In Proceedings of the 8th International Workshop on Osteoarthritis Imaging (IWOAI), Pacific Grove, CA, 2015.
Sveinsson B, Moran CJ, Yoon D, Gold G, Hargreaves B. Quantitative ADC Mapping Using DESS with Decreased T1 and Noise Sensitivity. In Proceedings of the 23rd International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Toronto, Canada, 2015.
Kogan F, Rosenberg J, McWalter EJ, Park D, Matzat S, Prekins K, Tran C, Taylor MI, Sveinsson B, Newbould RD, Monu U, Wang H, Bangerter N, Gold G. Quantitative MRI of Osteoarthritis for Multicenter Trials: Standardization Between Different Centers and Manufacturers. In Proceedings of the 22nd International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Milan, Italy, 2014.
McWalter EJ, Sveinsson B, Oei EHG, Robinson WH, Genovese MC, Gold G, Hargreaves B. Non-Contrast Diffusion-Weighted MRI for Detection of Synovitis Using DESS. In Proceedings of the 22nd International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Milan, Italy, 2014.
Oei EHG, McWalter EJ, Sveinsson B, Alley MT, Hargreaves BA, Gold GE. Non-Contrast Diffusion Weighted Imaging for the Assessment of Knee Synovitis: A Comparative Study Against Contrast-Enhanced MRI. In Proceedings of the OsteoArthritis Research Society International (OARSI) World Congress, Paris, France, 2014.
Asher KA, Sveinsson B, Gold GE. Comparison of T2 Relaxation Time in Knee Cartilage Using Quantitative DESS, CubeQuant and 2D-FSE. In Proceedings of the 21st International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Salt Lake City, UT, 2013.
Sveinsson B, Staroswiecki E, Granlund K, Gold GE, Hargreaves BA. Mapping of T2 and ADC in Articular Cartilage with B1 Corrected DESS. In Proceedings of the 20th International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Melbourne, Australia, 2012.
McWalter EJ, Sveinsson B, Staroswiecki E, Alley MT, Hargreaves BA, Gold GE. Rapid 3D Quantitative DESS T2 and T2* Mapping in the Meniscus. In Proceedings of the 20th International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Melbourne, Australia, 2012.
Shapiro LM, Sveinsson B, Alley MT, Hargreaves BA, Gold GE. Rapid Volumetric T2 Measurements in Muscle Pre- & Post-Exercise Using Quantitative DESS. In Proceedings of the 20th International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Melbourne, Australia, 2012.
Braun HJ, Sveinsson B, Alley MT, Dragoo JL, Jordan CD, Pappas G, Hargreaves BA, Gold GE. T2 Relaxation Times in Medial Compartment Osteoarthritis Using 3D Quantitative DESS (QDESS). In Proceedings of the 20th International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Melbourne, Australia, 2012.
Sveinsson B, Staroswiecki E, Gold GE, Hargreaves BA. Quantitative 3D Diffusion Musculoskeletal Imaging. In Proceedings of the Orthopaedic Research Society (ORS) Annual Meeting, San Francisco, CA, 2012.
Braun H, Sveinsson B, Dragoo JL, Hargreaves BA, Gold GE. 3D-DESS T2 Mapping Improves Resolution and Decreases Scan Time Versus 2D-T2 Mapping of Articular Cartilage. In Proceedings of the Orthopaedic Research Society (ORS) Annual Meeting, San Francisco, CA, 2012.
Awards
ISMRM Merit Award - Summa Cum Laude - Bragi Sveinsson (May 2016)
ISMRM Merit Award - Magna Cum Laude - Bragi Sveinsson (May 2015)
Acknowledgments
The study is funded by NIH R01 AR063643-01 and NIH R01 EB002524-01.
