Exploring the mammalian genetic determinants of the inducible response and cellular sensitivity to DNA damage and its effect on cancer susceptibility

Cellular responses to DNA damage. Different types of DNA damage cause a variety of different types of lesions, and these in turn are dealt with by a variety of DNA repair mechanisms and signal various cellular response pathways. The outcome of DNA damage may be cell survival of a normal cell, cell death or mutagenesis, possibly leading toward malignant transformation. 

DNA repair and the DNA damage response are essential not only for the basic processes of transcription and replication necessary for cellular survival, but also for maintaining genomic stability and avoiding the development of malignancies.

James Ford, M.D.
Division of Oncology
269 Campus Dr. CCSR Rm 1115
Stanford University School of Medicine
Stanford, CA 94305-5151

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