CXCR6⁺ CD127⁻ Tr1 Cells Balance Immunity and Persistence in Plasmodium falciparum Infection

Jason Nideffer, Florian Bach, Steven Strubbe, Luis Lopez, Maato Zedi, Felistas Nankya, Jessica Briggs, Kattria van der Ploeg, Kenneth Musinguzi, Soyeon Kim, Aracely Garcia Romero, Arefin Keya, Kylie Camanag, Savannah Lewis, Muhammad Abdelbasset, Bing Wang, Allison Boss, Evelyn Nansubuga, Joaniter I Nankabirwa, Emmanuel Arinaitwe, Saki Takahashi, Grant Dorsey, Bryan Greenhouse, Isabel Rodriguez-Barraquer, Moses R Kamya, Rosa Bacchetta, Isaac Ssewanyana, Ashraful Haque, Maria Grazia Roncarolo, Prasanna Jagannathan

Impact of intermittent preventive treatment for malaria in pregnancy with sulfadoxine-pyrimethamine, dihydroartemisinin-piperaquine, and their combination on infant outcomes: A randomized controlled trial

Joaniter I Nankabirwa, Abel Abel, Anna T Nguyen, Michelle E Roh, Miriam Aguti, Harriet Adrama, Jimmy Kizza, Peter Olwoch, Kylie Camanag, Jade Benjamin-Chung, Philip J Rosenthal, Moses R Kamya, Grant Dorsey, Prasanna Jagannathan

Cytotoxic Vδ2+T cell subsets expand in response to malaria in human tonsil and spleen organoids

Kathleen D. Press, Florian Bach, Elsa Sola, Kylie Camanag, Nicholas L. Dooley, Anselma Ivanawati, Damian Oyong, Mayimuna Nalubega, Abel Kakuru, Sedrack Matsiko, Nankya Felistas Namirimu, Kenneth Musinguzi, Annet Nalwoga, Evelyn Nansubuga, Johnie Ategeka, Ebusu Charles, Odongo Bakar, Chloe Kashiwagi, Xuhuai Ji, Molly Miranda, Joselyn Tachiwa-Appiah, Kareena Sandhu, Lilit Kamalyan, Kattria van der Ploeg, Michelle Boyle, Lisa E. Wagar, Mark Davis, Prasanna Jagannathan

Longitudinal Patient-Reported Outcome Trajectories in Long COVID: Findings From the STOP-PASC Clinical Trial

Prasanna Jagannathan, Haley, Hedlin, Jane W Liang, Blake Shaw, Evan Maestri, Michelle Lin, P J Utz, Upinder Singh, Linda N Geng, Hector Bonilla

Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses

Jason Nideffer, Florian Bach, Felistas Nankya, Kenneth Musinguzi, Šimon Borna, Michelle Mantilla, Maato Zedi, Aracely Garcia Romero, Chloe Gerungan, Nora Yang, Soyeon Kim, Kattria van der Ploeg, Kylie Camanag, Luis Lopez, Evelyn Nansubuga, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Potchara Boonrat, Steven Strubbe, Alma- Martina Cepika, Saki Takahashi, Grant Dorsey, Bryan Greenhouse, Isabel Rodriguez- Barraquer, Moses R. Kamya, Rosa Bacchetta, Isaac Ssewanyana, Ashraful Haque, Maria Grazia Roncarolo, Prasanna Jagannathan

Natural killer cell antibody‐dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission

Stephen Tukwasibwe, Savannah Nicole Lewis, Yoweri Taremwa, Kattria van der Ploeg, Kathleen D Press, Maureen Ty, Felistas Namirimu Nankya, Kenneth Musinguzi, Evelyn Nansubuga, Florian Bach, Martin Chamai, Martin Okitwi, Gerald Tumusiime, Annettee Nakimuli, Francesco Colucci, Moses R Kamya, Joaniter I Nankabirwa, Emmanuel Arinaitwe, Bryan Greenhouse, Grant Dorsey, Philip J Rosenthal, Isaac Ssewanyana, Prasanna Jagannathan

Gestational SARS-CoV-2 Infection in a Ugandan Birth Cohort: High Incidence, Mild Maternal Disease, and Evidence of Association with Transient Infant Stunting

Clinical immunity to malaria involves epigenetic reprogramming of innate immune cells

The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria

Michelle J. Boyle, Christian R. Engwerda, Prasanna Jagannathan

Monthly Sulfadoxine-Pyrimethamine During Pregnancy Prevents Febrile Respiratory Illnesses: A Secondary Analysis of a Malaria Chemoprevention Trial in Uganda

Jordan John Lee, Abel Kakuru, Karen B Jacobson, Moses R Kamya, Richard Kajubi, Anju Ranjit, Stephanie L Gaw, Julie Parsonnet, Jade Benjamin-Chung, Grant Dorsey, Prasanna Jagannathan, Michelle E Roh

Safety and efficacy of inhaled interferon-β1a (SNG001) in adults with mild-to-moderate COVID-19: a randomized, controlled, phase II trial

Prasanna Jagannathan, Kara W. Chew, Mark J. Giganti, Michael D. Hughes, Carlee Moser, Mark J. Main, Phillip D. Monk, Arzhang Cyrus Javan, Jonathan Z. Li, Courtney V. Fletcher, Caitlyn McCarthy, David A. Wohl, Eric S. Daar, Joseph J. Eron, Judith S. Currier, Upinder Singh, Davey M. Smith, William Fischer

Sex-Linked Differences in Malaria Risk Across the Lifespan

Jessica Briggs, Margaret Murray, Jason Nideffer, Prasanna Jagannathan

Malaria-specific Type 1 Regulatory T cells are more abundant in first pregnancies and associated with placental malaria

Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria

Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study

Malaria in 2022: Increasing challenges, cautious optimism. 

Jagannathan, P., Kakuru, A. Nature communications, 2022; 13 (1): 2678

TNF-alpha+ CD4+ Tcells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies. 

van der Ploeg, K., Kirosingh, A. S., Mori, D. A., Chakraborty, S., Hu, Z., Sievers, B. L., Jacobson, K. B., Bonilla, H., Parsonnet, J., Andrews, J. R., Press, K. D., Ty, M. C., Ruiz-Betancourt, D. R., de la Parte, L., Tan, G. S., Blish, C. A., Takahashi, S., Rodriguez-Barraquer, I., Greenhouse, B., Singh, U., Wang, T. T., Jagannathan, P. Cell reports. Medicine, 2022: 100640

Inflammatory but not respiratory symptoms are associated with ongoing upper airway viral shedding in outpatients with uncomplicated COVID-19

Karen B. Jacobson, Natasha Purington, Julie Parsonnet, Jason Andrews, Vidhya Balasubramanian, Hector Bonilla, Karlie Edwards, Manisha Desai, Upinder Singh, Haley Hedlin, Prasanna Jagannathan. Diagnostic microbiology and infectious disease, 102(3), 115612.

Age-related Changes in Malaria Clinical Phenotypes During Infancy are Modified by Sickle Cell Trait. 

Zehner, N., Adrama, H., Kakuru, A., Andra, T., Kajubi, R., Conrad, M., Nankya, F., Clark, T. D., Kamya, M., Rodriguez-Barraquer, I., Dorsey, G., Jagannathan, P. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021

Patients with uncomplicated COVID-19 have long-term persistent symptoms and functional impairment similar to patients with severe COVID-19: a cautionary tale during a global pandemic. 

Jacobson, K. B., Rao, M., Bonilla, H., Subramanian, A., Hack, I., Madrigal, M., Singh, U., Jagannathan, P., Grant, P. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021

Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial. 

Jagannathan, P. n., Andrews, J. R., Bonilla, H. n., Hedlin, H. n., Jacobson, K. B., Balasubramanian, V. n., Purington, N. n., Kamble, S. n., de Vries, C. R., Quintero, O. n., Feng, K. n., Ley, C. n., Winslow, D. n., Newberry, J. n., Edwards, K. n., Hislop, C. n., Choong, I. n., Maldonado, Y. n., Glenn, J. n., Bhatt, A. n., Blish, C. n., Wang, T. n., Khosla, C. n., Pinsky, B. A., Desai, M. n., Parsonnet, J. n., Singh, U. n. Nature communications, 2021; 12 (1): 1967

Infant sex modifies associations between placental malaria and risk of malaria in infancy. 

Kakuru, A. n., Roh, M. E., Kajubi, R. n., Ochieng, T. n., Ategeka, J. n., Ochokoru, H. n., Nakalembe, M. n., Clark, T. D., Ruel, T. n., Staedke, S. G., Chandramohan, D. n., Havlir, D. V., Kamya, M. R., Dorsey, G. n., Jagannathan, P. n. Malaria journal, 2020; 19 (1): 449

Intermittent preventive treatment with dihydroartemisinin-piperaquine and risk of malaria following cessation in young Ugandan children: a double-blind, randomised, controlled trial. 

Muhindo, M. K., Jagannathan, P., Kakuru, A., Opira, B., Olwoch, P., Okiring, J., Nalugo, N., Clark, T. D., Ruel, T., Charlebois, E., Feeney, M. E., Havlir, D. V., Dorsey, G., Kamya, M. R. The Lancet. Infectious diseases, 2019

Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial. 

Jagannathan, P., Kakuru, A., Okiring, J., Muhindo, M. K., Natureeba, P., Nakalembe, M., Opira, B., Olwoch, P., Nankya, F., Ssewanyana, I., Tetteh, K., Drakeley, C., Beeson, J., Reiling, L., Clark, T. D., Rodriguez-Barraquer, I., Greenhouse, B., Wallender, E., Aweeka, F., Prahl, M., Charlebois, E. D., Feeney, M. E., Havlir, D. V., Kamya, M. R., Dorsey, G. PLoS medicine, 2018; 15 (7): e1002606

Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. 

Jagannathan, P., Lutwama, F., Boyle, M. J., Nankya, F., Farrington, L. A., McIntyre, T. I., Bowen, K., Naluwu, K., Nalubega, M., Musinguzi, K., Sikyomu, E., Budker, R., Katureebe, A., Rek, J., Greenhouse, B., Dorsey, G., Kamya, M. R., Feeney, M. E. Scientific reports, 2017; 7 (1): 11487

Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4(+) T Cells and Limits Their Production of Immunoregulatory Interleukin 10

Jagannathan, P., Bowen, K., Nankya, F., McIntyre, T. I., Auma, A., Wamala, S., Sikyomu, E., Naluwu, K., Nalubega, M., Boyle, M. J., Farrington, L. A., Bigira, V., Kapisi, J., Aweeka, F., Greenhouse, B., Kamya, M., Dorsey, G., Feeney, M. E. JOURNAL OF INFECTIOUS DISEASES, 2016; 214 (2): 329-338

Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy 

Kakuru, A., Jagannathan, P., Muhindo, M. K., Natureeba, P., Awori, P., Nakalembe, M., Opira, B., Olwoch, P., Ategeka, J., Nayebare, P., Clark, T. D., Feeney, M. E., Charlebois, E. D., Rizzuto, G., Muehlenbachs, A., Havlir, D. V., Kamya, M. R., Dorsey, G. NEW ENGLAND JOURNAL OF MEDICINE, 2016; 374 (10): 928-939

Loss and dysfunction of Vδ2+ γδ T cells are associated with clinical tolerance to malaria. 

Jagannathan, P., Kim, C. C., Greenhouse, B., Nankya, F., Bowen, K., Eccles-James, I., Muhindo, M. K., Arinaitwe, E., Tappero, J. W., Kamya, M. R., Dorsey, G., Feeney, M. E. Science translational medicine, 2014; 6 (251): 251ra117-?

IFN gamma/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children

Jagannathan, P., Eccles-James, I., Bowen, K., Nankya, F., Auma, A., Wamala, S., Ebusu, C., Muhindo, M. K., Arinaitwe, E., Briggs, J., Greenhouse, B., Tappero, J. W., Kamya, M. R., Dorsey, G., Feeney, M. E. PLOS PATHOGENS, 2014; 10 (1)