Publications

Preprints

High rates of SARS-CoV-2 infection in pregnant Ugandan women and association with stunting in infancy

Karen B. Jacobson, Katharina Röltgen, Brandon Lam, Patience Nayebare, Abel Kakuru, Jimmy Kizza, Miriam Aguti, Felistas Nankya, Jessica Briggs, Saki Takahashi,  Bryan Greenhouse,  Isabel Rodriguez-Barraquer,  Kattria van der Ploeg, Jacob N. Wohlstadter,  George B. Sigal,  Michelle E Roh,  Joaniter I. Nankabirwa, Gloria Cuu,  Stephanie L. Gaw,  Philip J. Rosenthal,  Moses R. Kamya,  Isaac Ssewanyana,  Grant Dorsey, Scott D. Boyd, Prasanna Jagannathan

Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells

Jason Nideffer, Maureen Ty, Michele Donato, Rek John, Richard Kajubi, Xuhuai Ji, Holden Maecker, Felistas Nankya, Kenneth Musinguzi, Kathleen Dantzler Press, Bryan Greenhouse, Moses Kamya, Margaret E. Feeney, Grant Dorsey, PJ Utz, Bali Pulendran, Purvesh Khatri, Prasanna Jagannathan

2023

Malaria-specific Type 1 Regulatory T cells are more abundant in first pregnancies and associated with placental malaria

Adam Kirosingh, Alea Delmastro, Abel Kakuru, Kattria van der Ploeg, Sanchita Bhattacharya, Kathleen D. Press, Maureen Ty, Lauren de la Parte, Jimmy Kizza, Mary Muhindo, Sebastien Devachannee, Benoit Gamain, Felistas Nankya, Kenneth Musinguzi, Philip J Rosenthal, Margaret E. Feeney, Moses Kamya, Grant Dorsey, Prasanna Jagannathan

Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria

Maureen Ty, Shenghuan Sun, Perri C. Callaway, John Rek, Kathleen D. Press, Kattria van der Ploeg, Jason Nideffer, Zicheng Hu, Sandy Klemm, William Greenleaf, Michele Donato, Stephen Tukwasibwe, Emmanuel Arinaitwe, Felistas Nankya, Kenneth Musinguzi, Dean Andrew, Lauren de la Parte, Diego Martinez Mori, Savannah N. Lewis, Saki Takahashi, Isabel Rodriguez-Barraquer, Bryan Greenhouse, Catherine Blish, PJ Utz, Purvesh Khatri, Grant Dorsey, Moses Kamya, Michelle Boyle,Margaret Feeney, Isaac Ssewanyana, Prasanna Jagannathan

2022

Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study

Zicheng Hu, Kattria van der Ploeg, Saborni Chakraborty, Prabhu Arunachalam, Diego Mori, Karen Jacobson, Hector Bonilla, Julie Parsonnet, Jason Andrews, Haley Hedlin, Lauren de la Parte, Kathleen Dantzler, Maureen Ty, Gene Tan, Catherine Blish, Saki Takahashi, Isabel Rodriguez-Barraquer, Bryan Greenhouse, Atul Butte, Upinder Singh, Bali Pulendran, Taia Wang, Prasanna Jagannathan

Malaria in 2022: Increasing challenges, cautious optimism. 

Jagannathan, P., Kakuru, A. Nature communications, 2022; 13 (1): 2678

TNF-alpha+ CD4+ Tcells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies. 

van der Ploeg, K., Kirosingh, A. S., Mori, D. A., Chakraborty, S., Hu, Z., Sievers, B. L., Jacobson, K. B., Bonilla, H., Parsonnet, J., Andrews, J. R., Press, K. D., Ty, M. C., Ruiz-Betancourt, D. R., de la Parte, L., Tan, G. S., Blish, C. A., Takahashi, S., Rodriguez-Barraquer, I., Greenhouse, B., Singh, U., Wang, T. T., Jagannathan, P. Cell reports. Medicine, 2022: 100640

Inflammatory but not respiratory symptoms are associated with ongoing upper airway viral shedding in outpatients with uncomplicated COVID-19

Karen B. Jacobson, Natasha Purington, Julie Parsonnet, Jason Andrews, Vidhya Balasubramanian, Hector Bonilla, Karlie Edwards, Manisha Desai, Upinder Singh, Haley Hedlin, Prasanna Jagannathan. Diagnostic microbiology and infectious disease, 102(3), 115612.

2021

Age-related Changes in Malaria Clinical Phenotypes During Infancy are Modified by Sickle Cell Trait. 

Zehner, N., Adrama, H., Kakuru, A., Andra, T., Kajubi, R., Conrad, M., Nankya, F., Clark, T. D., Kamya, M., Rodriguez-Barraquer, I., Dorsey, G., Jagannathan, P. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021

Patients with uncomplicated COVID-19 have long-term persistent symptoms and functional impairment similar to patients with severe COVID-19: a cautionary tale during a global pandemic. 

Jacobson, K. B., Rao, M., Bonilla, H., Subramanian, A., Hack, I., Madrigal, M., Singh, U., Jagannathan, P., Grant, P. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021

Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial. 

Jagannathan, P. n., Andrews, J. R., Bonilla, H. n., Hedlin, H. n., Jacobson, K. B., Balasubramanian, V. n., Purington, N. n., Kamble, S. n., de Vries, C. R., Quintero, O. n., Feng, K. n., Ley, C. n., Winslow, D. n., Newberry, J. n., Edwards, K. n., Hislop, C. n., Choong, I. n., Maldonado, Y. n., Glenn, J. n., Bhatt, A. n., Blish, C. n., Wang, T. n., Khosla, C. n., Pinsky, B. A., Desai, M. n., Parsonnet, J. n., Singh, U. n. Nature communications, 2021; 12 (1): 1967

2020

Infant sex modifies associations between placental malaria and risk of malaria in infancy. 

Kakuru, A. n., Roh, M. E., Kajubi, R. n., Ochieng, T. n., Ategeka, J. n., Ochokoru, H. n., Nakalembe, M. n., Clark, T. D., Ruel, T. n., Staedke, S. G., Chandramohan, D. n., Havlir, D. V., Kamya, M. R., Dorsey, G. n., Jagannathan, P. n. Malaria journal, 2020; 19 (1): 449

2019

Intermittent preventive treatment with dihydroartemisinin-piperaquine and risk of malaria following cessation in young Ugandan children: a double-blind, randomised, controlled trial. 

Muhindo, M. K., Jagannathan, P., Kakuru, A., Opira, B., Olwoch, P., Okiring, J., Nalugo, N., Clark, T. D., Ruel, T., Charlebois, E., Feeney, M. E., Havlir, D. V., Dorsey, G., Kamya, M. R. The Lancet. Infectious diseases, 2019

2018

Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial. 

Jagannathan, P., Kakuru, A., Okiring, J., Muhindo, M. K., Natureeba, P., Nakalembe, M., Opira, B., Olwoch, P., Nankya, F., Ssewanyana, I., Tetteh, K., Drakeley, C., Beeson, J., Reiling, L., Clark, T. D., Rodriguez-Barraquer, I., Greenhouse, B., Wallender, E., Aweeka, F., Prahl, M., Charlebois, E. D., Feeney, M. E., Havlir, D. V., Kamya, M. R., Dorsey, G. PLoS medicine, 2018; 15 (7): e1002606

2017

Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. 

Jagannathan, P., Lutwama, F., Boyle, M. J., Nankya, F., Farrington, L. A., McIntyre, T. I., Bowen, K., Naluwu, K., Nalubega, M., Musinguzi, K., Sikyomu, E., Budker, R., Katureebe, A., Rek, J., Greenhouse, B., Dorsey, G., Kamya, M. R., Feeney, M. E. Scientific reports, 2017; 7 (1): 11487

2016

Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4(+) T Cells and Limits Their Production of Immunoregulatory Interleukin 10

Jagannathan, P., Bowen, K., Nankya, F., McIntyre, T. I., Auma, A., Wamala, S., Sikyomu, E., Naluwu, K., Nalubega, M., Boyle, M. J., Farrington, L. A., Bigira, V., Kapisi, J., Aweeka, F., Greenhouse, B., Kamya, M., Dorsey, G., Feeney, M. E. JOURNAL OF INFECTIOUS DISEASES, 2016; 214 (2): 329-338

Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy 

Kakuru, A., Jagannathan, P., Muhindo, M. K., Natureeba, P., Awori, P., Nakalembe, M., Opira, B., Olwoch, P., Ategeka, J., Nayebare, P., Clark, T. D., Feeney, M. E., Charlebois, E. D., Rizzuto, G., Muehlenbachs, A., Havlir, D. V., Kamya, M. R., Dorsey, G. NEW ENGLAND JOURNAL OF MEDICINE, 2016; 374 (10): 928-939

2014

Loss and dysfunction of Vδ2+ γδ T cells are associated with clinical tolerance to malaria. 

Jagannathan, P., Kim, C. C., Greenhouse, B., Nankya, F., Bowen, K., Eccles-James, I., Muhindo, M. K., Arinaitwe, E., Tappero, J. W., Kamya, M. R., Dorsey, G., Feeney, M. E. Science translational medicine, 2014; 6 (251): 251ra117-?

IFN gamma/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children

Jagannathan, P., Eccles-James, I., Bowen, K., Nankya, F., Auma, A., Wamala, S., Ebusu, C., Muhindo, M. K., Arinaitwe, E., Briggs, J., Greenhouse, B., Tappero, J. W., Kamya, M. R., Dorsey, G., Feeney, M. E. PLOS PATHOGENS, 2014; 10 (1)