Epidemiology and Outcomes
The following describes some of the ongoing research in the Division of Immunology and Rheumatology.
Dr. Fairchild utilizes ultrasound to evaluate and investigate rheumatologic disease in both clinical and research settings. He leads a team focused on novel applications of ultrasonography in systemic sclerosis (SSc) and connective tissue disease related pulmonary disease. In SSc, Dr. Fairchild's team uses ultrasound to better understand disease manifestations in the joints, tendons and soft tissues, and has broadened the scope of this tool in SSc, evaluating calcinosis, peripheral vascular disease, and their interrelationship in SSc. Initial ultrasound investigations into interstitial lung disease in SSc lead to broader research into screening and monitoring for lung disease in dermatomyositis, polymyositis, and mixed connective tissue disease. More recently, Dr. Fairchild’s team is using this technique to investigate pediatric lung disease in patients with connective tissue disease.
Dr. Katsumoto's research interests include the discovery of novel biomarkers to predict the development of immune-related adverse events in cancer patients on immune checkpoint inhibitor therapies, and optimizing the management of such complications. She is fascinated by the relationship between cancer and autoimmune diseases such as scleroderma adn dermatomyositis, the paraneoplastic mainfestations of various cancers, and the rheumatic complications of graft vs. host disease.
Dr. Sheth is performing epi and outcomes research studies on osteoarthritis. Using a variety of public and private databases she is leading research to identify risk factors for the development of OA, as well as drugs that might reduce OA development or progression. She is also interested in patient reported outcomes research and has worked with Kate Lorig to develop patient and physician satisfaction scales for rheumatology.
Dr. Simard studies outcomes in systemic autoimmune rheumatic disease, such as malignancy, stroke, infection, and mortality, but has shifted much of her focus to the intersection between reproductive epidemiology and rheumatic disease. She is also interested in disentangling social and biological constructs in the reported disparities in SLE with respect to sex, gender, race, and ethnicity, both from the etiologic and outcomes perspectives.
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