Journal Club 2021-2022

Seminars & Events

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Li Ka Shing Center (LKSC)

291 Campus Dr
Stanford CA, 94305
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Both MCTI and CSI students are required to attend the IMMUNOL 305 Immunology Journal Club for their First through Third years. Attendance is optional for Fourth year and above graduate students.

Journal Club is open to Stanford graduate students, postdocs, and faculty. Please refer to the schedule below. Faculty are encouraged to attend. The paper of the week will continue to be presented by a student; we ask that the presenting student’s advisor make every effort to attend the journal club to facilitate discussion.  If your student is presenting, they will contact you about scheduling. Papers will be posted on this page each week.

Autumn Quarter: Tuesdays at 2:45-3:45 PM, CCSR 4205, Contact Camilo at camiloe@stanford.edu for additional information.
Winter Quarter: Tuesdays at 3:15-4:15 PM, Location CCSR 4205 or Zoom, Contact Katherine at knico@stanford.edu for additional information.
Spring Quarter: Tuesdays at 3:15-4:15 PM, Location LK308, Contact Gabe at gbarron@stanford.edu.

Mar March 29 Tue 2022

Presenter: Ben Oberlton

Presenter’s Lab: Sean Bendall

Paper Name: T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10

Paper Citation: Ravi VM, Neidert N, Will P, Joseph K, Maier JP, Kückelhaus J, Vollmer L, Goeldner JM, Behringer SP, Scherer F, Boerries M, Follo M, Weiss T, Delev D, Kernbach J, Franco P, Schallner N, Dierks C, Carro MS, Hofmann UG, Fung C, Sankowski R, Prinz M, Beck J, Salié H, Bengsch B, Schnell O, Heiland DH. T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10. Nat Commun. 2022 Feb 17;13(1):925. doi: 10.1038/s41467-022-28523-1. PMID: 35177622; PMCID: PMC8854421.

Link: https://www.nature.com/articles/s41467-022-28523-1

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Apr April 05 Tue 2022

Presenter: Preksha Bhagchandani

Presenter’s Lab: Seung Kim and Everett Meyer

Paper Name: Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation

Paper Citation: Fueyo-González F, McGinty M, Ningoo M, Anderson L, Cantarelli C, Andrea Angeletti, Demir M, Llaudó I, Purroy C, Marjanovic N, Heja D, Sealfon SC, Heeger PS, Cravedi P, Fribourg M. Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation. Immunity. 2022 Mar 8;55(3):459-474.e7. doi: 10.1016/j.immuni.2022.01.011. Epub 2022 Feb 10. PMID: 35148827; PMCID: PMC8917088.

Link: https://www.sciencedirect.com/science/article/pii/S1074761322000401?via%3Dihub 

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Apr April 12 Tue 2022

Presenter: Flora Tierney

Presenter’s Lab: In rotation

Paper Name: CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection

Paper Citation: Özcan A, Collado-Diaz V, Egholm C, Tomura M, Gunzer M, Halin C, Kolios AGA, Boyman O. CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection. Sci Immunol. 2022 Feb 4;7(68):eabi9126. doi: 10.1126/sciimmunol.abi9126. Epub 2022 Feb 4. PMID: 35119939.

Link: https://www.science.org/doi/10.1126/sciimmunol.abi9126

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Apr April 19 Tue 2022

Presenter: Adonis Rubio and Chloe Kashiwagi

Presenter's Lab: In rotation

Paper Name: Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers

Paper Citation: Lee JH, Hu JK, Georgeson E, Nakao C, Groschel B, Dileepan T, Jenkins MK, Seumois G, Vijayanand P, Schief WR, Crotty S. Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers. J Exp Med. 2021 Feb 1;218(2):e20201254. doi: 10.1084/jem.20201254. PMID: 33355623; PMCID: PMC7769167.

Link: https://rupress.org/jem/article/218/2/e20201254/211636/Modulating-the-quantity-of-HIV-Env-specific-CD4-T

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Apr April 26 Tue 2022

Presenter: Anthony Francois and Azam Mohsin

Presenter's Lab: In rotation

Paper Name: CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours

Paper Citation: Larson RC, Kann MC, Bailey SR, Haradhvala NJ, Llopis PM, Bouffard AA, Scarfó I, Leick MB, Grauwet K, Berger TR, Stewart K, Anekal PV, Jan M, Joung J, Schmidts A, Ouspenskaia T, Law T, Regev A, Getz G, Maus MV. CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours. Nature. 2022 Apr;604(7906):563-570. doi: 10.1038/s41586-022-04585-5. Epub 2022 Apr 13. PMID: 35418687.

Link: https://www.nature.com/articles/s41586-022-04585-5

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May May 03 Tue 2022

Presenter: Potchara Boonrat and Alea Delmastro

Presenter's Lab: In rotation

Paper Name: Eosinophils are an essential element of a type 2 immune

axis that controls thymus regeneration

Paper Citation: Cosway EJ, White AJ, Parnell SM, Schweighoffer E, Jolin HE, Bacon A, Rodewald HR, Tybulewicz V, McKenzie ANJ, Jenkinson WE, Anderson G. Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration. Sci Immunol. 2022 Mar 11;7(69):eabn3286. doi: 10.1126/sciimmunol.abn3286. Epub 2022 Mar 11. PMID: 35275754; PMCID: PMC7612579.

Link: https://www.science.org/doi/full/10.1126/sciimmunol.abn3286?af=R

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May May 10 Tue 2022

Presenter: Karan Kathuria

Presenter's Lab: Mark Davis

Paper Name: Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus

Paper Citation: Shinzawa M, Moseman EA, Gossa S, Mano Y, Bhattacharya A, Guinter T, Alag A, Chen X, Cam M, McGavern DB, Erman B, Singer A. Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus. Nat Immunol. 2022 Apr 29. doi: 10.1038/s41590-022-01187-1. Epub ahead of print. PMID: 35523960.

Link: https://www.nature.com/articles/s41590-022-01187-1

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May May 17 Tue 2022

Presenter: Vishnu Shankar

Presenter's Lab: In rotation

Paper Name: Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs. 

Paper Citation: Eschweiler S, Ramírez-Suástegui C, Li Y, King E, Chudley L, Thomas J, Wood O, von Witzleben A, Jeffrey D, McCann K, Simon H, Mondal M, Wang A, Dicker M, Lopez-Guadamillas E, Chou TF, Dobbs NA, Essame L, Acton G, Kelly F, Halbert G, Sacco JJ, Schache AG, Shaw R, McCaul JA, Paterson C, Davies JH, Brennan PA, Singh RP, Loadman PM, Wilson W, Hackshaw A, Seumois G, Okkenhaug K, Thomas GJ, Jones TM, Ay F, Friberg G, Kronenberg M, Vanhaesebroeck B, Vijayanand P, Ottensmeier CH. Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs. Nature. 2022 May 4. doi: 10.1038/s41586-022-04685-2. Epub ahead of print. PMID: 35508656.

Link: https://www.nature.com/articles/s41586-022-04685-2

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May May 24 Tue 2022

Presenter: David Seong

Presenter's Lab: In rotation

Paper Name: Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response

Paper Citation: Denton AE, Dooley J, Cinti I, Silva-Cayetano A, Fra-Bido S, Innocentin S, Hill DL, Carr EJ, McKenzie ANJ, Liston A, Linterman MA. Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response. Sci Immunol. 2022 May 6;7(71):eabk0018. doi: 10.1126/sciimmunol.abk0018. Epub 2022 May 6. PMID: 35522725.

Link: https://www.science.org/doi/10.1126/sciimmunol.abk0018

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May May 31 Tue 2022

Presenter: Colin Raposo

Presenter's Lab: In rotation

Paper Name: Replicative history marks transcriptional and functional disparity in the CD8 + T cell memory pool

Paper Citation: Bresser K, Kok L, Swain AC, King LA, Jacobs L, Weber TS, Perié L, Duffy KR, de Boer RJ, Scheeren FA, Schumacher TN. Replicative history marks transcriptional and functional disparity in the CD8+ T cell memory pool. Nat Immunol. 2022 May;23(5):791-801. doi: 10.1038/s41590-022-01171-9. Epub 2022 Apr 7. PMID: 35393592.

Link: https://www.nature.com/articles/s41590-022-01171-9 

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Jun June 07 Tue 2022

Presenter: Pat Yan

Presenter's Lab: In rotation

Paper Name: Autoreactive CD8 + T cells are restrained by an exhaustion-like program that is maintained by LAG3

Paper Citation: Grebinoski S, Zhang Q, Cillo AR, Manne S, Xiao H, Brunazzi EA, Tabib T, Cardello C, Lian CG, Murphy GF, Lafyatis R, Wherry EJ, Das J, Workman CJ, Vignali DAA. Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3. Nat Immunol. 2022 May 26. doi: 10.1038/s41590-022-01210-5. Epub ahead of print. PMID: 35618829.

Link: https://www.nature.com/articles/s41590-022-01210-5

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