Rapid 3D MRI
Clinical knee MRI examinations typically utilize 2D imaging methods with thick slices, requiring upwards of 20-25 minutes of scan time, and yet not producing any quantitative information. New rapid 3D MRI methods can great reduce scan time while at the same time providing additional diagnostic information and detecting early disease features.
Our work aims to improve the value of MRI in diagnostic joint imaging through new MRI methods to reduce scan time and improve resolution and visualization of fine structures. We are also working to incorporate new methods to evaluate synovitis and tissue microstructure which cannot be assessed with conventional MRI. Lastly, we hope to do this in both knees simultaneously, without added scan time.
Chaudhari A, Kogan F, Pedoia V, Majumdar S, Gold GE, Hargreaves BA. Rapid Knee MRI Acquisition and Analysis Techniques for Imaging Osteoarthritis. Journal of Magnetic Resonance Imaging. 2019.
Chaudhari A, Stevens K, Sveinsson B, Wood J, Beaulieu CF, Oei EHG, Rosenberg J, Kogan F, Alley M, Gold GE, Hargreaves BA. Combined 5-Minute Double-Echo in Steady-State with Separated Echoes and 2-Minute Proton-Density-Weighted 2D FSE Sequence for Comprehensive Whole-Joint Knee MRI Assessment. Journal of Magnetic Resonance Imaging. 2019. 49(7):e184-e194 (2019 ISMRM W. S. Moore Young Investigator Award Winner)
Chaudhari A, Fang Z, Kogan F, Wood J, Stevens K, Gibbons E, Lee JH, Gold GE, Hargreaves BA. Super-Resolution Musculoskeletal MRI Using Deep Learning. Magnetic Resonance in Medicine. 2018; 80 (5):2139-2154. (Editors Pick)
Kogan F, Levine E, Chaudhari A, Monu U, Epperson K, Oei E, Gold G, Hargreaves B. Simultaneous Bilateral-Knee MR Imaging. Magnetic Resonance in Medicine. 2018; 80(2):529-537.
Kogan F, Hargreaves B, Gold G. Volumetric Multi-Slice GagCEST Imaging of Articular Cartilage: Optimization & Comparison with T1rho. Magnetic Resonance in Medicine. 2017;77(3):1134-1141
McWalter EJ,KoganT2 Relaxation time quantitation differs between pulse sequences in articular cartilage. Journal of Magnetic Resonance Imaging. 2015 Jul;42(1):105-13
Singh A, Haris M, Cai K, Kogan F., Hariharan H, Reddy R. High Resolution T1p Mapping of In Vivo Human Knee Cartilage at 7T. PLos One. 2014;9(5):e97486