IMF Group Awarded R01 to Study Imaging Joint Response to Loading in OA
The IMF Group was awarded an R01 Award by the National Institute of Arthritis and Musculoskeletal and Skin Disorders (NAIMS) of the National Institutes of Health (NIH) to pursue a project about "Imaging of Joint Response to Physiological Stress with Age, Sex and in Osteoarthritis".
Osteoarthritis (OA) is a leading cause of pain, reduced joint function, and disability, that reduces productivity and quality of life at tremendous cost to society. Diagnostic imaging of OA is limited by methods that largely assess late-stage disease changes or require longitudinal scanning and are performed in a static fashion that has limited sensitivity to joint function in response to loading from everyday tasks such as walking or climbing stairs. This work aims to develop a novel imaging “stress test”, based on [18F]NaF PET-MRI, that is able to evaluate at a single time point, both the function of the whole-joint unit from physiological joint loading and multiple early markers of OA.