The IMF Group was awarded an R01 Award by the National Institute of
Arthritis and Musculoskeletal and Skin Disorders (NAIMS) of the National
Institutes of Health (NIH) to pursue a project about "Imaging of Joint Response to Physiological Stress with Age, Sex and in Osteoarthritis".
Osteoarthritis (OA) is a leading cause of pain, reduced joint
function, and disability, that reduces productivity and quality of life
at tremendous cost to society. Diagnostic imaging of OA is limited by
methods that largely assess late-stage disease changes or require
longitudinal scanning and are performed in a static fashion that has
limited sensitivity to joint function in response to loading from
everyday tasks such as walking or climbing stairs. This work aims to
develop a novel imaging “stress test”, based on [18F]NaF PET-MRI, that
is able to evaluate at a single time point, both the function of the
whole-joint unit from physiological joint loading and multiple early
markers of OA.