Publications

Research Articles

1. Chang KC, Bian M, Xia X, Madaan A, Sun C, Wang Q, Li L, Nahmou M, Noro T, Yokota S, Galvao J, Kreymerman A, Tanasa B, Hu Y, Goldberg JL. Post-translational modification of Sox11 regulates RGC survival and axon regeneration. eNeuro. 2021 Jan 12:ENEURO.0358-20.2020. doi: 10.1523/ENEURO.0358-20.2020. PMID: 33441400

2. Patel AK, Broyer RM, Lee CD, Lu T, Louie MJ, La Torre A, Al-Ali H, Vu MT, Mitchell KL, Wahlin KJ, Berlinicke CA, Jaskula-Ranga V, Hu Y, Duan X, Vilar S, Bixby JL, Weinreb RN, Lemmon VP, Zack DJ, Welsbie DS. Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. PNAS. 2020 Dec 14:202004683. doi: 10.1073/pnas.2004683117. PMID: 33318207.

3. Ning K, Song E, Sendayen BE, Prosseda PP, Chang KC, Ghaffarieh A, Alvarado JA, Wang B, Haider KM, Berbari NF, Hu Y, Sun Y. Defective INPP5E distribution in NPHP1-related Senior-Loken syndrome. Mol Genet Genomic Med. 2020 Dec 11:e1566. doi: 10.1002/mgg3.1566. PMID: 33306870.

4. Niu J, Sanders SS, Jeong HK, Holland SM, Sun Y, Collura KM, Hernandez LM, Huang H, Hayden MR, Smith GM, Hu Y, Jin Y, Thomas GM. Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17. Cell Rep2020 Nov 17;33(7):108365. doi: 10.1016/j.celrep.2020.108365. PMID: 33207199.

5. Alvarado J. A., Dhande O. S., Prosseda P. P., Kowal T. J., Ning K., Jabbehdari S., Hu Y., Sun, Y. Developmental Distribution of Primary Cilia in the Retinofugal Visual Pathway. J Comp Neurol2020 Sep 17. doi: 10.1002/cne.25029. PMID: 32939774.

6. Zhang Y, Zhang S, Xia Y, Ji Y, Jiang W, Li M, Huang H, Xu M, Sun J, Ye Q, Hu Y, Wu W.  In Vivo Evaluation of Retinal Ganglion Cells and Optic Nerve's Integrity in Large Animals by Multi-Modality Analysis. Exp Eye Res. 2020 Jun 26:108117. doi: 10.1016/j.exer.2020.108117. (co-corresponding author) PMID: 32598972

7. Wang Q, Zhuang P, Huang H, Li L, Liu L, Webber HC, Dalal R, Siew L, Fligor CM, Chang K, Nahmou M, Kreymerman A, Sun Y, Meyer JS, Goldberg JL, Hu Y. Mouse gamma-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells. Journal of Neuroscience. 2020; 2020 May 13;40(20):3896-3914. doi: 10.1523/JNEUROSCI.0102-20.2020. PMC7219295

8. Prosseda PP, Alvarado JA, Wang B, Kowal TJ, Ning Ke, Stamer WD, Hu Y, Sun Y. Optogenetic Stimulation of Aqueous Outflow: the Role of Phosphoinositides in Eye Pressure Regulation. Science Advances 2020; Apr 29;6(18):eaay8699. doi: 10.1126/sciadv.aay8699.

9. Li L, Huang H, Fang F, Liu L, Sun Y, Hu Y. Longitudinal Morphological and Functional Assessment of RGC Neurodegeneration After Optic Nerve Crush in Mouse. Frontiers in Cellular Neuroscience. 2020; DOI: 10.3389/fncel.2020.00109

10. Zhang, J., Fang, F., Li, L., Huang, H., Webber, H. C., Sun, Y., Mahajan, V. B., Hu, Y. A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice. J. Vis. Exp. 2019 (153), e60409, doi:10.3791/60409. PMC6938455

11. Starr CR, Nyankerh CNA, Qi X, Hu Y, Gorbatyuk OS, Sonenberg N, Boulton ME, Gorbatyuk MS. Role of Translational Attenuation in Inherited Retinal Degeneration. Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4849-4857. doi: 10.1167/iovs.19-27512. PMC6871337

12. Zhang J, Li L, Huang H, Fang F, Webber HC, Zhuang P, Liu L, Dalal R, Tang PH, Mahajan VB, Sun Y, Li S, Zhang M, Goldberg JL, Hu Y. Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse. Elife.   2019 May 15;8. pii: e45881. doi: 10.7554/eLife.45881.

13. Kumar V, Mesentier-Louro LA, Oh AJ, Heng K, Shariati MA, Huang H, Hu Y, Liao YJ. Increased ER Stress After Experimental Ischemic Optic Neuropathy and Improved RGC and Oligodendrocyte Survival After Treatment With Chemical Chaperon. Invest Ophthalmol Vis Sci. 2019 May 1;60(6):1953-1966. doi: 10.1167/iovs.18-24890. PMID: 31060051.   

14. Huang H, Miao L, Yang L, Liang F, Wang Q, Zhuang P, Sun Y, Hu Y. AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration. Cell Death Dis. 2019 Feb 27;10(3):203. doi: 10.1038/s41419-018-1289-z. PMCID: PMC6393504.

15. Wang Q, Wu Z, Zhang J, Firrman J, Wei H, Zhuang Z, Liu L, Miao L, Hu Y, Li D, Diao Y, Xiao W. A Robust System for Production of Superabundant VP1 Recombinant AAV VectorsMolecular Therapy — Methods & Clinical Development.2017 Nov 7; 7:146-156. doi: 10.1016/j.omtm.2017.11.002. eCollection 2017 Dec 15. PMC5721209

16. Prosseda PP, Luo N, Wang B, Alvarado JA, Hu Y, Sun Y. Loss of OCRL increases ciliary PI(4,5)P2 in oculocerebrorenal syndrome of Lowe. J Cell Sci. 2017 Sep 4. pii: jcs.200857. doi: 10.1242/jcs.200857. PMC5665444

17. Huang H, Miao L, Liang F, Liu X, Xu L, Teng X, Wang Q, Ridder WH 3rd, Shindler KS, Sun Y, Hu Y.
Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss. Cell Death Dis. 2017 Jul 20;8(7):e2936. doi: 10.1038/cddis.2017.329. PMC5550873

18. Yang L, Li S, Miao L, Huang H, Liang F, Teng X, Xu L, Wang Q, Xiao W, Ridder WH 3rd, Ferguson TA, Chen DF, Kaufman RJ, Hu Y. Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal ER Stress Molecules. Journal of Neuroscience. 2016 May 25;36(21):5891-903. doi: 10.1523/JNEUROSCI.3709-15. PMC4879204

19. Miao L, Yang L, Huang H, Liang F, Ling C, Hu Y. mTORC1 Is Necessary But mTORC2 And GSK3β Are Inhibitory For AKT3-Induced Axon Regeneration in the Central Nervous System. Elife. 2016 Mar 30;5. pii: e14908. doi: 10.7554/eLife.14908. PMCID: PMC4841781

20. Yang L, Miao L, Liang F, Huang H, Teng X, Li S, Nuriddinov J, Selzer ME and Hu Y. The mTORC1 Effectors S6K1 and 4E-BP Play Different Roles in CNS Axon Regeneration. Nature Communications. 2014 Nov 10;5:5416. doi: 10.1038/ncomms6416 PMCID: PMC4228696.

21. Hu Y, Park KK, Yang L, Wei X, Yang Q, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF and He Z. Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells. Neuron. 2012 Volume 73, Issue 3, 9 February 2012, Pages 445-452 (co-corresponding author)  PMC3278720

22. Park, KK.*, Liu, K.*, Hu, Y.*, Smith, PD.*, Wang, C., Cai, B., Kramvis, I., Sahin, M. and He, Z. Promoting Axon Regeneration in the Adult CNS by Modulating the PTEN/mTOR Pathway.  Science 2008 Nov 7;322(5903):963-6. (co-first author). PMC2652400

23. Hu, Y.1, Park-Min, KH.1, Yarilina, A. and Ivashkiv, LB. Regulation of STAT Pathways and IRF1 During Human Dendritic Cell Maturation by TNFα and PGE2. Journal of Leukocyte Biology 2008 Nov;84(5):1353-60. (co-first author)

24. Hu, Y, Hu, X, Boumsell, L, Ivashkiv, LB. IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways.  Journal of Immunology 2008 Jun 15;180(12):8057-65.

25. Tassiulas I, Park-Min KH, Hu Y, Kellerman L, Mevorach D, Ivashkiv LB. Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages. Hum Immunol. 2007 Mar; 68(3):156-64.

26. Hu, Y. and Ivashkiv LB. Costimulation of Chemokine Receptor Signaling by MMP-9 Mediates Enhanced Migration of IFNα-DCs.  Journal of Immunology 2006 May 15; 176 (10): 6022-603.

27. Sharif MN, Tassiulas I, Hu Y., Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB IFN-alpha priming results in a gain of proinflammatory function by IL-10: Implications for systemic lupus erythematosus pathogenesis. Journal of Immunology 2004 May 15; 172(10): 6476-6481.

28. Hu, Y., Chuang, JZ., Xu, K., McGraw, TG, Sung, CH. SARA, a FYVE domain protein, affects Rab5-mediated endocytosis. Journal of Cell Science 2002 DEC 15, 115 (24): 4755-4763.
 


Review Articles

1. Xu Y, Fan X, Hu Y. In vivo interactome profiling by enzyme-catalyzed proximity labeling. Cell Biosci. 2021 Jan 29;11(1):27. doi: 10.1186/s13578-021-00542-3. PMID: 33514425

2. Zhang J, Hu Y. Comparing silicone oil-induced ocular hypertension with other inducible glaucoma models in mice. Neural Regen Res. 2020 Sep;15(9):1652-1653. doi: 10.4103/1673-5374.276330.

3. Chen W, Hu Y, Ju D. Gene therapy for neurodegenerative disorders: advances, insights and prospects. Acta Pharmaceutica Sinica B. 2020 DOI: 10.1016/j.apsb.2020.01.015

4. Ma X, Ning K, Jabbehdari S, Prosseda PP, Hu Y, Shue A, Lambert SR, Sun Y. Oculocerebrorenal syndrome of Lowe: Survey of ophthalmic presentations and management. Euro J. Ophthalmology, 2020, Apr 27;1120672120920544. doi: 10.1177/1120672120920544. PMID: 32340490

5. Huang H, Kaur S, Hu Y. Lab review: Molecular dissection of the signal transduction pathways associated with PTEN deletion-induced optic nerve regeneration. Restor Neurol Neurosci. 2019;37(6):545-552. doi: 10.3233/RNN-190949. PMC6938454

6. Zhang J, Yang D, Huang H, Sun Y, Hu Y. Coordination of Necessary and Permissive Signals by PTEN Inhibition for CNS Axon Regeneration. Front Neurosci. 2018 Aug 13;12:558. doi: 10.3389/fnins.2018.00558. eCollection 2018. Review. PMCID: PMC6104488.

7. Hu Y. Axon injury induced endoplasmic reticulum stress and neurodegeneration. Neural Regen Res 2016 11(10):1557-1559. (Invited Review) PMC5116825

8. Hu Y. The necessary role of mTORC1 in central nervous system axon regeneration. Neural Regen Res 2015 Feb. 10(2):186-188. PMCID: PMC4392657 (Invited perspective) PMC4392657

9. Li S, Yang L, Selzer ME, Hu Y. Neuronal ER stress in Axon Injury and Neurodegeneration. Annals of Neurology. 2013 Dec;74(6):768-77. doi: 10.1002/ana.24005. Epub 2013 Oct 7. (Review) PMCID: PMC3963272.

10. Park KK, Liu K, Hu Y, Kanter JL, He Z. PTEN/mTOR and axon regeneration. Exp Neurol. 2010 Jan 14. (Review).

11. Ge, Z., Hu, Y., Heng, BC, Yang, Z., Ouyang, H., Lee, EH and Cao T. Osteoarthritis and Therapy.  Arthritis & Rheumatism  2006 Jun 15;55(3):493-500 (Review).