Research

SOHU Glaucoma Model

In Vivo Light-evoked RGC Ca^2+ Imaging

Retrograde Tracing Regenerating RCGs

Funding

Publications

For a full and current list of publications visit Dr. Yang Hu's CAP profile here. 
 
  1. Liu P, Chen W, Jiang H, Huang H, Liu L, Fang F, Li L, Feng X, Liu D, Dalal R, Sun Y, Jafar-Nejad P, Ling K, Rigo F, Ye J, Hu Y.
    Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies
    Mol Ther Nucleic Acids. 2023 Feb 27;32:13-27. doi: 10.1016/j.omtn.2023.02.029. PMC10025007

  2. Moshiri A, Fang F, Zhuang P, Huang H, Feng X, Li L, Dalal R, Hu Y.
    Silicone Oil-Induced Glaucomatous Neurodegeneration in Rhesus Macaques.
    Int J Mol Sci. 2022 Dec 14;23(24):15896. doi: 10.3390/ijms232415896. PMC9781764

  3. Li L, Feng X, Fang F, Miller DA, Zhang S, Zhuang P, Huang H, Liu P, Liu J, Sredar N, Liu L, Sun Y, Duan X, Goldberg JL, Zhang HF, Hu Y.
    Longitudinal In Vivo Ca2+ Imaging Reveals Dynamics Activity Changes of Diseased Retinal Ganglion Cells at Single-Cell Level.
    Proc Natl Acad Sci U S A. 2022. Nov 29;119(48):e2206829119. DOI: 10.1073/pnas.2206829119 PMC9889883

  4. Chen W, Liu P, Liu D, Huang H, Feng X, Fang F, Li L, Wu J, Liu L, Solow-Cordero DE, Hu Y.
    Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells.
    Nature Communications.2022 Nov 10;13(1):6796. DOI: 10.1038/s41467-022-34682-y. PMC9649812

  5. Au, N. P., Kumar, G., Asthana, P., Gao, F., Kawaguchi, R., Chang, R. C., So, K. F., Hu, Y., Geschwind, D. H., Coppola, G., Ma, C. H.
    Clinically relevant small-molecule promotes nerve repair and visual function recovery
    NPJ Regen Med. 2022 Oct 1;7(1):50. doi: 10.1038/s41536-022-00233-8. PMC9526721

  6. Li L, Fang F, Feng X, Zhuang P, Huang H, Liu P, Liu L, Xu AZ, Qi LS, Cong L, Hu Y.
    Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes.
    Neuron. 2022 Aug 6;S0896-6273(22)00601-8. doi: 10.1016/j.neuron.2022.06.022. PMC9391304

  7. Kowal TJ, Dhande OS, Wang B, Wang Q, Ning K, Liu W, Berbari NF, Hu Y, Sun Y.
    Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells
    J Comp Neurol. 2022 Apr 17. doi: 10.1002/cne.25326. PMC9219574

  8. Guo LY, Bian J, Davis AE, Liu P, Kempton HR, Zhang X, Chemparathy A, Gu B, Lin X, Rane DA, Xu X, Jamiolkowski RM, Hu Y, Wang S, Qi LS.
    Multiplexed genome regulation in vivo with hyper-efficient Cas12a.
    Nat Cell Biol. 2022 Apr 12. doi: 10.1038/s41556-022-00870-7. PMC9035114

  9. Zhang Y, Lu S, Huang S, Yu Z, Xia T, Li M, Yang C, Mao Y, Xu B, Wang L, Xu L, Shi J, Zhu X, Zhu S, Zhang S, Qian H, Hu Y, Li W, Tu Y, Wu W.
    Optic chiasmatic potential by endoscopically implanted skull base microinvasive biosensor: a brain-machine interface approach for anterior visual pathway assessment
    Theranostics. 2022 Apr 11;12(7):3273-3287. doi: 10.7150/thno.71164. PMC9065198

  10. Zhang Y, Li M, Yu B, Lu S, Zhang L, Zhu S, Yu Z, Xia T, Huang H, Jiang W, Zhang S, Sun L, Ye Q, Sun J, Zhu H, Huang P, Hong H, Yu S, Li W, Ai D, Fan J, Li W, Song H, Xu L, Chen X, Chen T, Zhou M, Ou J, Yang J, Li W, Hu Y, Wu W.
    Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy
    eLife 2022 Mar 30;11:e75070. doi: 10.7554/eLife.75070. PMC9068221

  11. Fang F, Zhuang P, Feng X, Liu P, Liu D, Huang H, Li L, Chen We, Liu L, Sun Y, Jiang H, Ye J, Hu Y.
    NMNAT2 Is Downregulated in Glaucomatous RGCs and RGC-Specific Gene Therapy Rescues Neurodegeneration and Visual Function
    Molecular Therapy. 2022 Jan 31:S1525-0016(22)00074-0. DOI: 10.1016/j.ymthe.2022.01.035. PMC9077370

  12. Liu P, Huang H, Fang F, Liu L, Li L, Feng X, Chen W, Dalal R, Sun Y, Hu Y
    Neuronal NMNAT2 Overexpression Does Not Achieve Significant Neuroprotection in Experimental Autoimmune Encephalomyelitis/Optic Neuritis
    Frontiers in Cellular Neuroscience. 2021; Oct 11;15:754651. DOI: 10.3389/fncel.2021.754651. PMC8542903

  13. Ning K, Sendayen BE, Kowal TJ, Wang B, Jones BW, Hu Y, Sun Y.
    Primary Cilia in Amacrine Cells in Retinal Development
    Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):15. doi: 10.1167/iovs.62.9.15. PMC8287049

  14. Wang B, He W, Prosseda PP, Li L, Kowal TJ, Alvarado JA, Wang Q, Hu Y, Sun Y.
    OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring
    EMBO Rep. 2021 Jul 5;22(7):e52173. doi: 10.15252/embr.202052173. PMC8406401

  15. Alvarado JA, Dhande OS, Prosseda PP, Kowal TJ, Ning K, Jabbehdari S, Hu Y, Sun Y. Developmental distribution of primary cilia in the retinofugal visual pathway.
    J Comp Neurol. 2021 May 1;529(7):1442-1455. doi: 10.1002/cne.25029. PMC7965790.

  16. Kowal, T. J., Prosseda, P. P., Ning, K., Wang, B., Alvarado, J., Sendayen, B. E., Jabbehdari, S., Stamer, W., Hu, Y., Sun, Y.
    Optogenetic Modulation of Intraocular Pressure in a Glucocorticoid-Induced Ocular Hypertension Mouse Model.
    Translational Vision Science & Technology 2021, May 3;10(6):10. DOI: 10.1167/tvst.10.6.10. PMC8107493

  17. Fang F, Zhang J, Zhuang P, Liu P, Li L, Huang H, Webber HC, Xu Y, Liu L, Dalal R, Sun Y, Hu Y.
    Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension.
    Sci Rep. 2021 Apr 27;11(1):9052. doi: 10.1038/s41598-021-88690-x. PMC8079709

  18. Chang KC, Bian M, Xia X, Madaan A, Sun C, Wang Q, Li L, Nahmou M, Noro T, Yokota S, Galvao J, Kreymerman A, Tanasa B, Hu Y, Goldberg JL.
    Post-translational modification of Sox11 regulates RGC survival and axon regeneration.
    eNeuro. 2021 Jan 12:ENEURO.0358-20.2020. DOI: 10.1523/ENEURO.0358-20.2020. PMC7890524

  19. Patel AK, Broyer RM, Lee CD, Lu T, Louie MJ, La Torre A, Al-Ali H, Vu MT, Mitchell KL, Wahlin KJ, Berlinicke CA, Jaskula-Ranga V, Hu Y, Duan X, Vilar S, Bixby JL, Weinreb RN, Lemmon VP, Zack DJ, Welsbie DS.
    Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons.
    Proc Natl Acad Sci U S A. 2020 Dec 14:202004683. DOI: 10.1073/pnas.2004683117. PMC7777023

  20. Ning K, Song E, Sendayen BE, Prosseda PP, Chang KC, Ghaffarieh A, Alvarado JA, Wang B, Haider KM, Berbari NF, Hu Y, Sun Y.
    Defective INPP5E distribution in NPHP1-related Senior-Loken syndrome.
    Mol Genet Genomic Med. 2021 Jan;9(1):e1566. doi: 10.1002/mgg3.1566. PMC7963418

  21. Niu J, Sanders SS, Jeong HK, Holland SM, Sun Y, Collura KM, Hernandez LM, Huang H, Hayden MR, Smith GM, Hu Y, Jin Y, Thomas GM.
    Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17
    Cell Rep. 2020 Nov 17;33(7):108365. doi: 10.1016/j.celrep.2020.108365. PMC7803378

  22. Ma X, Ning K, Jabbehdari S, Prosseda PP, Hu Y, Shue A, Lambert SR, Sun Y
    Oculocerebrorenal syndrome of Lowe: Survey of ophthalmic presentations and management.
    Euro J. Ophthalmology, 2020, Sep;30(5):966-973. DOI: 10.1177/1120672120920544. PMC8177091

  23. Zhang Y, Zhang S, Xia Y, Ji Y, Jiang W, Li M, Huang H, Xu M, Sun J, Ye Q, Hu Y, Wu W. In Vivo Evaluation of Retinal Ganglion Cells and Optic Nerve's Integrity in Large Animals by Multi-Modality Analysis
    Exp Eye Res. 2020 Aug;197:108117. DOI: 10.1016/j.exer.2020.108117

  24. Wang Q, Zhuang P, Huang H, Li L, Liu L, Webber HC, Dalal R, Siew L, Fligor CM, Chang K, Nahmou M, Kreymerman A, Sun Y, Meyer JS, Goldberg JL, Hu Y.
    Mouse gamma-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells.
    Journal of Neuroscience. 2020; May 13;40(20):3896-3914. DOI: 10.1523/JNEUROSCI.0102-20.2020 PMC7219295

  25. Prosseda PP, Alvarado JA, Wang B, Kowal TJ, Ning Ke, Stamer WD, Hu Y, Sun Y
    Optogenetic Stimulation of Aqueous Outflow: the Role of Phosphoinositides in Eye Pressure Regulation.
    Science Advances 2020; May;6(18):eaay8699. doi: 10.1126/sciadv.aay8699. PMC7190330

  26. Li L, Huang H, Fang F, Liu L, Sun Y, Hu Y.
    Longitudinal Morphological and Functional Assessment of RGC Neurodegeneration After Optic Nerve Crush in Mouse.
    Frontiers in Cellular Neuroscience. 2020; Apr 29;14:109. DOI: 10.3389/fncel.2020.00109. PMC7200994

  27. Zhang, J., Fang, F., Li, L., Huang, H., Webber, H. C., Sun, Y., Mahajan, V. B., Hu, Y.
    A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice.
    J. Vis. Exp. 2019 Nov 15;(153). doi: 10.3791/60409. PMC6938455

  28. Starr CR, Nyankerh CNA, Qi X, Hu Y, Gorbatyuk OS, Sonenberg N, Boulton ME, Gorbatyuk MS.
    Role of Translational Attenuation in Inherited Retinal Degeneration.
    Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4849-4857. doi: 10.1167/iovs.19-27512. PMC6871337.

  29. Zhang J, Li L, Huang H, Fang F, Webber HC, Zhuang P, Liu L, Dalal R, Tang PH, Mahajan VB, Sun Y, Li S, Zhang M, Goldberg JL, Hu Y.
    Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse.
    Elife. 2019 May 15;8. pii: e45881. doi: 10.7554/eLife.45881. PMC6533060

  30. Kumar V, Mesentier-Louro LA, Oh AJ, Heng K, Shariati MA, Huang H, Hu Y, Liao YJ.
    Increased ER Stress After Experimental Ischemic Optic Neuropathy and Improved RGC and Oligodendrocyte Survival After Treatment With Chemical Chaperon.
    Invest Ophthalmol Vis Sci. 2019 May 1;60(6):1953-1966. DOI: 10.1167/iovs.18-24890. PMC6735778.

  31. Huang H, Miao L, Yang L, Liang F, Wang Q, Zhuang P, Sun Y, Hu Y.
    AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration.
    Cell Death Dis. 2019 Feb 27;10(3):203. doi: 10.1038/s41419-018-1289-z. PMC6393504.

  32. Wang Q, Wu Z, Zhang J, Firrman J, Wei H, Zhuang Z, Liu L, Miao L, Hu Y, Li D, Diao Y, Xiao W.
    A Robust System for Production of Superabundant VP1 Recombinant AAV Vectors.
    Molecular Therapy — Methods & Clinical Development. 2017 Dec 15;7:146-156. DOI: 10.1016/j.omtm.2017.11.002. PMC5721209.

  33. Prosseda PP, Luo N, Wang B, Alvarado JA, Hu Y, Sun Y.
    Loss of OCRL increases ciliary PI(4,5)P2 in oculocerebrorenal syndrome of Lowe.
    J Cell Sci. 2017 Sep 4. pii: jcs.200857. doi: 10.1242/jcs.200857. PMC5665444.

  34. Huang H, Miao L, Liang F, Liu X, Xu L, Teng X, Wang Q, Ridder WH 3rd, Shindler KS, Sun Y, Hu Y.
    Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritis.
    Cell Death Dis. 2017 Jul 20;8(7):e2936. doi: 10.1038/cddis.2017.329. PMC5550873

  35. Yang L, Li S, Miao L, Huang H, Liang F, Teng X, Xu L, Wang Q, Xiao W, Ridder WH 3rd, Ferguson TA, Chen DF, Kaufman RJ, Hu Y.
    Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal ER Stress Molecules.
    Journal of Neuroscience. 2016 May 25;36(21):5891-903. DOI: 10.1523/JNEUROSCI.3709-15.2016. PMC4879204

  36. Miao L, Yang L, Huang H, Liang F, Ling C, Hu Y.
    mTORC1 Is Necessary But mTORC2 And GSK3β Are Inhibitory For AKT3-Induced Axon Regeneration in the Central Nervous System.
    Elife. 2016 Mar 30;5. pii: e14908. doi: 10.7554/eLife.14908. PMC4841781

  37. Yang L, Miao L, Liang F, Huang H, Teng X, Li S, Nuriddinov J, Selzer ME and Hu Y.
    The mTORC1 Effectors S6K1 and 4E-BP Play Different Roles in CNS Axon Regeneration.
    Nature Communications. 2014 Nov 10;5:5416. doi: 10.1038/ncomms6416 PMC4228696

  38. Hu Y, Park KK, Yang L, Wei X, Yang Q, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF and He Z.
    Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells.
    Neuron. 2012 Volume 73, Issue 3, 9 February 2012, Pages 445-452. doi: 10.1016/j.neuron.2011.11.026.. PMC3278720

  39. Park, KK.*, Liu, K.*, Hu, Y.*, Smith, PD.*, Wang, C., Cai, B., Kramvis, I., Sahin, M. and He, Z.
    Promoting Axon Regeneration in the Adult CNS by Modulating the PTEN/mTOR Pathway.
    Science 2008 Nov 7;322(5903):963-6. doi: 10.1126/science.1161566. PMC2652400 (co-first author).

  40. Hu, Y.1, Park-Min, KH.1, Yarilina, A. and Ivashkiv, LB.
    Regulation of STAT Pathways and IRF1 During Human Dendritic Cell Maturation by TNFα and PGE2.
    Journal of Leukocyte Biology 2008 Nov;84(5):1353-60. DOI: 10.1189/jlb.0107040. PMC2567899

  41. Hu, Y, Hu, X, Boumsell, L, Ivashkiv, LB.
    IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways.
    Journal of Immunology 2008 Jun 15;180(12):8057-65. DOI: 10.4049/jimmunol.180.12.8057. PMC2742170

  42. Tassiulas I, Park-Min KH, Hu Y, Kellerman L, Mevorach D, Ivashkiv LB.
    Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages.
    Hum Immunol. 2007 Mar; 68(3):156-64. DOI: 10.1016/j.humimm.2006.12.008. PMC2736914

  43. Hu, Y. and Ivashkiv LB.
    Costimulation of Chemokine Receptor Signaling by MMP-9 Mediates Enhanced Migration of IFNα-DCs.
    Journal of Immunology 2006 May 15; 176 (10): 6022-603. DOI: 10.4049/jimmunol.176.10.6022. PMID: 16670311

  44. Sharif MN, Tassiulas I, Hu Y., Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB
    IFN-alpha priming results in a gain of proinflammatory function by IL-10: Implications for systemic lupus erythematosus pathogenesis.
    Journal of Immunology 2004 May 15; 172(10): 6476-6481. DOI: 10.4049/jimmunol.172.10.6476. PMID: 15128840

  45. Hu, Y., Chuang, JZ., Xu, K., McGraw, TG, Sung, CH.
    SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.
    Journal of Cell Science 2002 DEC 15, 115 (24): 4755-4763. DOI: 10.1242/jcs.00177. PMC3899687

Other Publications

Reviews, perspectives, articles, book chapters, and patents

1. Xu Y, Fan X, Hu Y. In vivo interactome profiling by enzyme-catalyzed proximity labeling. Cell Biosci. 2021 Jan 29;11(1):27. doi: 10.1186/s13578-021-00542-3. PMID: 33514425

2. Zhang J, Hu Y. Comparing silicone oil-induced ocular hypertension with other inducible glaucoma models in mice. Neural Regen Res. 2020 Sep;15(9):1652-1653. doi: 10.4103/1673-5374.276330.

3. Chen W, Hu Y, Ju D. Gene therapy for neurodegenerative disorders: advances, insights and prospects. Acta Pharmaceutica Sinica B. 2020 DOI: 10.1016/j.apsb.2020.01.015

4. Ma X, Ning K, Jabbehdari S, Prosseda PP, Hu Y, Shue A, Lambert SR, Sun Y. Oculocerebrorenal syndrome of Lowe: Survey of ophthalmic presentations and management. Euro J. Ophthalmology, 2020, Apr 27;1120672120920544. doi: 10.1177/1120672120920544. PMID: 32340490

5. Huang H, Kaur S, Hu Y. Lab review: Molecular dissection of the signal transduction pathways associated with PTEN deletion-induced optic nerve regeneration. Restor Neurol Neurosci. 2019;37(6):545-552. doi: 10.3233/RNN-190949. PMC6938454

6. Zhang J, Yang D, Huang H, Sun Y, Hu Y. Coordination of Necessary and Permissive Signals by PTEN Inhibition for CNS Axon Regeneration. Front Neurosci. 2018 Aug 13;12:558. doi: 10.3389/fnins.2018.00558. eCollection 2018. Review. PMCID: PMC6104488.

7. Hu Y. Axon injury induced endoplasmic reticulum stress and neurodegeneration. Neural Regen Res 2016 11(10):1557-1559. (Invited Review) PMC5116825

8. Hu Y. The necessary role of mTORC1 in central nervous system axon regeneration. Neural Regen Res 2015 Feb. 10(2):186-188. PMCID: PMC4392657 (Invited perspective) PMC4392657

9. Li S, Yang L, Selzer ME, Hu Y. Neuronal ER stress in Axon Injury and Neurodegeneration. Annals of Neurology. 2013 Dec;74(6):768-77. doi: 10.1002/ana.24005. Epub 2013 Oct 7. (Review) PMCID: PMC3963272.

10. Park KK, Liu K, Hu Y, Kanter JL, He Z. PTEN/mTOR and axon regeneration. Exp Neurol. 2010 Jan 14. (Review).

11. Ge, Z., Hu, Y., Heng, BC, Yang, Z., Ouyang, H., Lee, EH and Cao T. Osteoarthritis and Therapy.  Arthritis & Rheumatism  2006 Jun 15;55(3):493-500 (Review).
 

Book Chapters

Chapter 11, Eye Injuries, in “Current Occupational and Environmental Medicine, sixth Edition”, 2020, McGraw-Hill, New York