HTSKC Publications (formerly HTBC)

HTSKC users are requested to acknowledge the Sarafan ChEM-H High-Throughput Screening Knowledge Center in all publications that have results generated from HTSKC equipment or services.   Users should also acknowledge appropriate HTSKC support mechanisms such as, the Stanford Cancer Center, Digestive Disease Center, Spectrum, SPARK, Innovative Medicine Accelerator, or instrumentation grant number.

2023

  1. A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson's disease.
    Vinita Bharat, Aarooran S Durairaj, Roeland Vanhauwaert, Li Li, Colin M Muir, Sujyoti Chandra, Chulhwan S Kwak, Yann Le Guen, Pawan Nandakishore, Chung-Han Hsieh, Stefano E Rensi, Russ B Altman, Michael D Greicius, Liang Feng, Xinnan Wang. 
    Cell Rep. 2023 Dec 26;42(12):113544. Epub 2023 Dec 6. PubMedID: 38060381 PMCID: PMCTBD DOI: 10.1016/j.celrep.2023.113544
  2. Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease.
    Ellen R Bowen, Phillip DiGiacomo, Hannah P Fraser, Kevin Guttenplan, Benjamin A H Smith, Marlene L Heberling, Laura Vidano, Nigam Shah, Mehrdad Shamloo, Jennifer L Wilson, Kevin V Grimes. 
    Discov Ment Health. 2023 Nov 30;3(1):27. PubMedID: 38036718 PMCID: PMC10689618 DOI: 10.1007/s44192-023-00050-5
  3. Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects.
    Sirle Saul, Marwah Karim, Pei-Tzu Huang, Winston Chiu,  Verónica Durán, Chieh-Wen Lo, Sathish Kumar, Nishank Bhalla, Pieter Leyssen, Farhang Alem, Niloufar A Boghdeh, Do HoangNhu Tran, Courtney A Cohen, Jacquelyn A Brown, Kathleen Huie, Courtney Tindle, Mamdouh Sibai,  Chengjin Ye, Ahmed Magdy Khalil, Kevin Chiem, Luis Martinez-Sobrido, John M Dye, Benjamin A Pinsky, Pradipta Ghosh, Soumita Das, David E Solow-Cordero, Jing Jin,  John P Wikswo, Dirk Jochmans, Johan Neyts, Steven De Jonghe, Aarthi Narayanan, Shirit Einav. 
    J Clin Invest. 2023 Oct 2;133(19):e169510. PubMedID: 37581931 PMCID: PMC10541190 DOI: 10.1172/JCI169510 
  4. Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.
    Katharina Papsdorf, Jason W Miklas, Amir Hosseini, Matias Cabruja, Christopher S Morrow, Marzia Savini, Yong Yu, Carlos G Silva-García, Nicole R Haseley, Luke Meraz Murphy, Pallas Yao, Elisa de Launoit, Scott J Dixon, Michael P Snyder, Meng C Wang, William B Mair, Anne Brunet.
    Nat Cell Biol. 2023 May;25(5):672-684. Epub 2023 May 1. PubMedID:  37127715  PMCID: PMC10185472  DOI: 10.1038/s41556-023-01136-6
  5. Quantifying bias introduced by sample collection in relative and absolute microbiome measurements.
    Dylan G Maghini, Mai Dvorak, Alex Dahlen, Morgan Roos, Scott Kuersten, Ami S Bhatt.
    Nat Biotechnol. 2023 Apr 27. Online ahead of print. PubMedID: 37106038  PMCID: PMCTBD  DOI: 10.1038/s41587-023-01754-3
  6. The Tomato Brown Rugose Fruit Virus Movement Protein Gene Is a Novel Microbial Source Tracking Marker.
    Aravind Natarajan, Brayon J Fremin, Danica T Schmidtke, Marlene K Wolfe, Soumaya Zlitni, Katherine E Graham, Erin F Brooks, Christopher J Severyn, Kathleen M Sakamoto, Norman J Lacayo, Scott Kuersten, Jeff Koble, Glorianna Caves, Inna Kaplan, Upinder Singh, Prasanna Jagannathan, Andrew R Rezvani, Ami S Bhatt, Alexandria B Boehm.
    Appl Environ Microbiol. 2023 Jul 26;89(7):e0058323. Epub 2023 Jul 5. PubMedID: 37404180  PMCID: PMC10370318  DOI: 10.1128/aem.00583-23 
  7. Reversible 2'-OH acylation enhances RNA stability.
    Linglan Fang, Lu Xiao, Yong Woong Jun, Yoshiyuki Onishi, Eric T Kool.
    Nat Chem. 2023 Sep;15(9):1296-1305. Epub 2023 Jun 26. PubMedID: 37365334  PMCID: PMCTBD  DOI: 10.1038/s41557-023-01246-6
  8. The molecular mechanism of CD81 antibody inhibition of metastasis.
    Niroz Abu-Saleh, Chiung-Chi Kuo, Wei Jiang, Ronald Levy, Shoshana Levy.
    Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2305042120. Epub 2023 Jun 20. PubMedID: 37339209  PMCID: PMC10293848  DOI: 10.1073/pnas.2305042120
  9. Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control.
    Yan Gao, Yousuf A Khan, Weike Mo, K Ian White, Matthew Perkins, Richard A Pfuetzner, Josef G Trapani, Axel T Brunger, Teresa Nicolson.
    Cell Rep. 2023 Apr 25;42(4):112345. Epub 2023 Apr 5. PubMedID: 37027300  PMCID: PMC10524599  DOI: 10.1016/j.celrep.2023.112345
  10. Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor.
    Kailu Yang, Chuchu Wang, Alex J B Kreutzberger, K Ian White, Richard A Pfuetzner, Luis Esquivies, Tomas Kirchhausen, Axel T Brunger.
    Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2300360120. Epub 2023 Mar 20. PubMedID: 36940324  PMCID: PMC10068829  DOI: 10.1073/pnas.2300360120
  11. Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation.
    Weili Miao, Douglas F Porter, Vanessa Lopez-Pajares, Zurab Siprashvili, Robin M Meyers, Yunhao Bai, Duy T Nguyen, Lisa A Ko, Brian J Zarnegar, Ian D Ferguson, Matthew M Mills, Christie E Jilly-Rehak, Cheng-Guo Wu, Yen-Yu Yang, Jordan M Meyers, Audrey W Hong, David L Reynolds, Muthukumar Ramanathan, Shiying Tao, Sizun Jiang, Ryan A Flynn, Yinsheng Wang, Garry P Nolan, Paul A Khavari.
    Cell. 2023 Jan 5;186(1):80-97.e26. PubMedID: 36608661  PMCID: PMC10171372  DOI: 10.1016/j.cell.2022.12.004
  12. Engineering circular RNA for enhanced protein production.
    Robert Chen, Sean K Wang, Julia A Belk, Laura Amaya, Zhijian Li, Angel Cardenas, Brian T Abe, Chun-Kan Chen, Paul A Wender, Howard Y Chang.
    Nat Biotechnol. 2023 Feb;41(2):262-272. Epub 2022 Jul 18. PubMedID: 35851375  PMCID: PMC9931579  DOI: 10.1038/s41587-022-01393-0

2022

  1. Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.
    John Janetzko, Ryoji Kise, Benjamin Barsi-Rhyne, Dirk H Siepe, Franziska M Heydenreich, Kouki Kawakami, Matthieu Masureel, Shoji Maeda, K Christopher Garcia, Mark von Zastrow, Asuka Inoue, Brian K Kobilka.
    Cell. 2022 Nov 23;185(24):4560-4573.e19. Epub 2022 Nov 10.    PubMedID: 36368322 PMCID: PMC10030194 DOI: 10.1016/j.cell.2022.10.018
  2. Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells.
    Wei Chen, Pingting Liu, Dong Liu, Haoliang Huang, Xue Feng, Fang Fang, Liang Li, Jian Wu, Liang Liu, David E Solow-Cordero, Yang Hu.
    Nat Commun. 2022 Nov 10;13(1):6796.    PubMedID: 36357388 PMCID: PMC9649812 DOI: 10.1038/s41467-022-34682-y
  3. Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2.
    Caitlin M Rodriguez, Sophia C Bechek, Graham L Jones, Lisa Nakayama, Tetsuya Akiyama, Garam Kim, David E Solow-Cordero, Stephen M Strittmatter, Aaron D Gitler .
    Cell Rep. 2022 Oct 25;41(4):111505.    PubMedID: 36288715 PMCID: PMC9664481 DOI: 10.1016/j.celrep.2022.111505  
  4. miR-409-3p represses Cited2 to refine neocortical layer V projection neuron identity.
    Nikolaus R Wagner, Ashis Sinha, Verl Siththanandan, Angelica M Kowalchuk, Jessica L MacDonald, Suzanne Tharin.
    Front Neurosci. 2022 Sep 29;16:931333. eCollection 2022.    PubMedID: 36248641 PMCID: PMC9558290  DOI: 10.3389/fnins.2022.931333
  5. Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.
    Kailu Yang, Chuchu Wang, Alex J B Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J Eisen, K Ian White, Richard G Held, Subu Subramanian, Kendra Marcus, Richard A Pfuetzner, Luis Esquivies, Catherine A Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen, Axel T Brunger.
    Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2210990119. Epub 2022 Sep 19.   PubMedID:36122200 PMCID: PMC9546559  DOI: 10.1073/pnas.2210990119
  6. Highly multiplexed selection of RNA aptamers against a small molecule library.
    Brent Townshend, Matias Kaplan, Christina D Smolke.
    PLoS One. 2022 Sep 15;17(9):e0273381. eCollection 2022. PubMedID: 36107884 PMCID: PMC9477273 DOI: 10.1371/journal.pone.0273381  
  7. Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes.
    Ning Deng, Yun-Yun Wu, Yanan Feng, Wen-Chieh Hsieh, Jen-Shin Song, Yu-Shiuan Lin, Ya-Hsien Tseng, Wan-Jhu Liao, Yi-Fan Chu, Yu-Cheng Liu, En-Cheng Chang, Chia-Rung Liu, Sheh-Yi Sheu, Ming-Tsan Su, Hung-Chih Kuo, Stanley N Cohen, Tzu-Hao Cheng.
    Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2204779119. Epub 2022 Aug 1. PubMedID: 35914128 PMCID: PMC9371670 DOI: 10.1073/pnas.2204779119
  8. Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection.
    Aravind Natarajan, Soumaya Zlitni, Erin F Brooks, Summer E Vance, Alex Dahlen, Haley Hedlin, Ryan M Park, Alvin Han, Danica T Schmidtke, Renu Verma, Karen B Jacobson, Julie Parsonnet, Hector F Bonilla, Upinder Singh, Benjamin A Pinsky, Jason R Andrews, Prasanna Jagannathan, Ami S Bhatt.
    Med (N Y). 2022 Jun 10;3(6):371-387.e9. Epub 2022 Apr 13.   PubMedID: 35434682 PMCID: PMC9005383 DOI: 10.1016/j.medj.2022.04.001  
  9. Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle.
    Kailu Yang, Chuchu Wang, K Ian White, Richard A Pfuetzner, Luis Esquivies, Axel T Brunger.
    Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2119467119. Epub 2022 Apr 1.   PubMedID: 35363556 PMCID: PMC9169775 DOI: 10.1073/pnas.2119467119
  10. Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides.
    Ying Lai, Giorgio Fois, Jose R Flores, Michael J Tuvim, Qiangjun Zhou, Kailu Yang, Jeremy Leitz, John Peters, Yunxiang Zhang, Richard A Pfuetzner, Luis Esquivies, Philip Jones, Manfred Frick, Burton F Dickey, Axel T Brunger.
    Nature. 2022 Mar;603(7903):949-956. Epub 2022 Mar 23.   PubMedID: 35322233 PMCID: PMC8967716 DOI: 10.1038/s41586-022-04543-1 
  11. Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging.
    Adelaida R Palla, Keren I Hilgendorf, Ann V Yang, Jaclyn P Kerr, Aaron C Hinken, Janos Demeter, Peggy Kraft, Nancie A Mooney, Nora Yucel, David M Burns, Yu Xin Wang, Peter K Jackson, Helen M Blau.
    Nat Commun. 2022 Mar 17;13(1):1439.   PubMedID: 35301320 PMCID: PMC8931095 DOI: 10.1038/s41467-022-29150-6
  12. Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia.
    Kaiming Zhang, Naoki Horikoshi, Shanshan Li, Alexander S Powers, Mikhail A Hameedi, Grigore D Pintilie, Hee-Don Chae, Yousuf A Khan, Carl-Mikael Suomivuori, Ron O Dror, Kathleen M Sakamoto, Wah Chiu, Soichi Wakatsuki.
    ACS Cent Sci. 2022 Feb 23;8(2):214-222. Epub 2022 Feb 7.   PubMedID: 35233453 PMCID: PMC8875425 DOI: 10.1021/acscentsci.1c01090
  13. Ponatinib, Lestaurtinib, and mTOR/PI3K Inhibitors Are Promising Repurposing Candidates against Entamoeba histolytica.
    Monica M Kangussu-Marcolino, Upinder Singh.
    Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0120721. Epub 2021 Dec 6.   PubMedID: 34871094 PMCID: PMC8846492 DOI: 10.1128/AAC.01207-21

2021

  1. Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis.
    Madeleine Dorsch, Manuela Kowalczyk, Mélanie Planque, Geronimo Heilmann, Sebastian Urban, Philip Dujardin, Jan Forster, Kristina Ueffing, Silke Nothdurft, Sebastian Oeck, Annika Paul, Sven T. Liffers, Farnusch Kaschani, Markus Kaiser, Alexander Schramm, Jens T. Siveke, Monte M. Winslow, Sarah-Maria Fendt, Perihan Nalbant, and Barbara M. Grüner.
    Cell Rep. 2021 Nov 23;37(8):110056. PMCID: PMC8640221   PubMedID: 34818551 DOI: 10.1016/j.celrep.2021.110056  
  2. The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation.
    Daniel S Kim, Viviana I Risca, David L Reynolds, James Chappell, Adam J Rubin, Namyoung Jung, Laura K H Donohue, Vanessa Lopez-Pajares, Arwa Kathiria, Minyi Shi, Zhixin Zhao, Harsh Deep, Mahfuza Sharmin, Deepti Rao, Shin Lin, Howard Y Chang, Michael P Snyder, William J Greenleaf, Anshul Kundaje, Paul A Khavari.
    Nat Genet. 2021 Nov;53(11):1564-1576. Epub 2021 Oct 14.  PubMedID: 34650237 PMCID: PMC8763320 DOI: 10.1038/s41588-021-00947-3
  3. Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA.
    Aravind Natarajan, Alvin Han, Soumaya Zlitni, Erin F Brooks, Summer E Vance, Marlene Wolfe, Upinder Singh, Prasanna Jagannathan, Benjamin A Pinsky, Alexandria Boehm, Ami S Bhatt.
    Nat Commun. 2021 Oct 1;12(1):5753.   PubMedID: 34599164 PMCID: PMC8486790 DOI: 10.1038/s41467-021-25576-6
  4. Self-Assembled, Dilution-Responsive Hydrogels for Enhanced Thermal Stability of Insulin Biopharmaceuticals.
    Catherine M Meis, Erika E Salzman, Caitlin L Maikawa, Anton A A Smith, Joseph L Mann, Abigail K Grosskopf, Eric A Appel.
    ACS Biomater Sci Eng. 2021 Sep 13;7(9):4221-4229. Epub 2020 Nov 17. PubMedID: 34510910 PMCID: PMC8441967 DOI: 10.1021/acsbiomaterials.0c01306
  5. High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment.
    Veronica D Gonzalez, Ying-Wen Huang, Antonio Delgado-Gonzalez, Shih-Yu Chen, Kenyi Donoso, Karen Sachs, Andrew J Gentles, Grace M Allard, Kevin S Kolahi, Brooke E Howitt, Ermelinda Porpiglia, Wendy J Fantl.
    Cell Rep. 2021 Aug 31;36(9):109632. PubMedID: 34469729 PMCID: PMC8546503 DOI: 10.1016/j.celrep.2021.109632
  6. Two new hybrid populations expand the swordtail hybridization model system.
    Daniel L. Powell, Ben Moran, Bernard Kim, Shreya M. Banerjee, Stepfanie M. Aguillon, Paola Fascinetto-Zago, Quinn Langdon, Molly Schumer.
    Evolution. 2021 Oct;75(10):2524-2539. Epub 2021 Sep 13. PubMedID: 34460102 PMCID: PMC8659863 DOI: 10.1111/evo.14337
  7. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis.
    Zewen Jiang, Meng Zhao, Laetitia Voilquin, Yunshin Jung, Mari A Aikio, Tanushi Sahai, Florence Y Dou, Alexander M Roche, Ivan Carcamo-Orive, Joshua W Knowles, Martin Wabitsch, Eric A Appel, Caitlin L Maikawa, Joao Paulo Camporez, Gerald I Shulman, Linus Tsai, Evan D Rosen, Christopher D Gardner, Bruce M Spiegelman, Katrin J Svensson.
    Cell Metab. 2021 Sep 7;33(9):1836-1852.e11. Epub 2021 Aug 3. PubMedID: 34348115 PMCID: PMC8429235 DOI: 10.1016/j.cmet.2021.07.010
  8. Engineering Insulin Cold Chain Resilience to Improve Global Access.
    Caitlin L Maikawa, Joseph L Mann, Aadithya Kannan, Catherine M Meis, Abigail K Grosskopf, Ben S Ou, Anton A A Autzen, Gerald G Fuller, David M Maahs, Eric A Appel.
    Biomacromolecules. 2021 Aug 9;22(8):3386-3395. Epub 2021 Jul 2.   PubMedID: 34213889 PMCID: PMC8627795 DOI: 10.1021/acs.biomac.1c00474
  9. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. Manal Mehibel, Yu Xu, Caiyun G Li, Eui Jung Moon, Kaushik N Thakkar, Anh N Diep, Ryan K Kim, Joshua D Bloomstein, Yiren Xiao, Julien Bacal, Joshua C Saldivar, Quynh-Thu Le, Karlene A Cimprich, Erinn B Rankin, Amato J Giaccia. J Clin Invest. 2021 Jun 1;131(11):e146256. PubMedID: 34060485 PMCID: PMC8266208 DOI: 10.1172/JCI146256
  10. Modulation of injectable hydrogel properties for slow co-delivery of influenza subunit vaccine components enhance the potency of humoral immunity.
    Olivia M Saouaf, Gillie A Roth, Ben S Ou, Anton A A Smith, Anthony C Yu, Emily C Gale, Abigail K Grosskopf, Vittoria C T M Picece, Eric A Appel.
    J Biomed Mater Res A. 2021 Nov;109(11):2173-2186. Epub 2021 May 6. PubMedID: 33955657 PMCID: PMC8518857 DOI: 10.1002/jbm.a.37203
  11. iPSC-endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension.
    Mingxia Gu, Michele Donato, Minzhe Guo, Neil Wary, Yifei Miao, Shuai Mao, Toshie Saito, Shoichiro Otsuki, Lingli Wang, Rebecca L Harper, Silin Sa, Purvesh Khatri, Marlene Rabinovitch.
    J Sci Transl Med. 2021 May 5;13(592):eaba6480. PubMedID: 33952674 PMCID: PMC8762958 DOI: 10.1126/scitranslmed.aba6480
  12. T cell reactivity to regulatory factor X4 in type 1 narcolepsy.
    Guo Luo, Selina Yogeshwar, Ling Lin, Emmanuel Jean-Marie Mignot.
    Sci Rep. 2021 Apr 9;11(1):7841.  PubMedID: 33837283 PMCID: PMC8035403 DOI: 10.1038/s41598-021-87481-8
  13. The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infectiony.
    Zhiyuan Yao, Fabio Zanini, Sathish Kumar, Marwah Karim, Sirle Saul, Nishank Bhalla, Nuttada Panpradist, Avery Muniz, Aarthi Narayanan, Stephen R Quake, Shirit Einav.
    PLoS Negl Trop Dis. 2021 Mar 31;15(3):e0009306. eCollection 2021 Mar.  PubMedID:33788849 PMCID: PMC8041203 DOI: 10.1371/journal.pntd.0009306
  14. Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea.
    Marie Kubota, Mirko Scheibinger, Taha A Jan, Stefan Heller.
    Cell Rep. 2021 Jan 19;34(3):108646.   PubMedID: 33472062 PMCID: PMC7847202 DOI: 10.1016/j.celrep.2020.108646

 

2020

  1. Bistable, Biphasic Regulation of PP2A-B55 Accounts for the Dynamics of Mitotic Substrate Phosphorylation.
    Julia Kamenz, Lendert Gelens, James E Ferrell Jr.
    Curr Biol. 2020 Dec 19;S0960-9822(20)31771-1.   PubMedID: 33357450 DOI: 10.1016/j.cub.2020.11.058  
  2. How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling.
    Naomi R Latorraca, Matthieu Masureel, Scott A Hollingsworth, Franziska M Heydenreich, Carl-Mikael Suomivuori, Connor Brinton, Raphael J L Townshend, Michel Bouvier, Brian K Kobilka, Ron O Dror.
    Cell. 2020 Dec 23;183(7):1813-1825.e18.  Epub 2020 Dec 8.   PubMedID: 33296703 PMCID: PMC7901245 DOI: 10.1016/j.cell.2020.11.014
  3. Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion.
    Momei Zhou, Vivek Kamarshi, Ann M Arvin, Stefan L Oliver.
    PLoS Pathog. 2020 Nov 20;16(11):e1009022. eCollection 2020 Nov.   PubMedID: 33216797 PMCID: PMC7717522 DOI: 10.1371/journal.ppat.1009022
  4. Injectable Hydrogels for Sustained Codelivery of Subunit Vaccines Enhance Humoral Immunity.
    Gillie A Roth, Emily C Gale, Marcela Alcántara-Hernández, Wei Luo, Eneko Axpe, Rohit Verma, Qian Yin, Anthony C Yu, Hector Lopez Hernandez, Caitlin L Maikawa, Anton A A Smith, Mark M Davis, Bali Pulendran, Juliana Idoyaga, Eric A Appel.
    ACS Cent Sci. 2020 Oct 28;6(10):1800-1812. Epub 2020 Sep 16.   PubMedID: 33145416 PMCID: PMC7596866 DOI: 10.1021/acscentsci.0c00732
  5. An evolutionarily acquired microRNA shapes development of mammalian cortical projections.
    Jessica L Diaz, Verl B Siththanandan, Victoria Lu, Nicole Gonzalez-Nava, Lincoln Pasquina, Jessica L MacDonald, Mollie B Woodworth, Abdulkadir Ozkan, Ramesh Nair, Zihuai He, Vibhu Sahni, Peter Sarnow, Theo D Palmer, Jeffrey D Macklis, Suzanne Tharin.
    Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29113-29122. Epub 2020 Nov 2.   PubMedID: 33139574 PMCID: PMC7682328 DOI: 10.1073/pnas.2006700117
  6. An anchoring molecule increases intravitreal retention of antibody-based therapeutics used in the treatment of ocular diseases.
    Quanqing Gao, Ira H Schachar.
    J Control Release. 2020 Dec 10;328:263-275. Epub 2020 Aug 25.    PubMedID:32858075 PMCID: PMC7749058 DOI: 10.1016/j.jconrel.2020.08.034
  7. The Apparent Requirement for Protein Synthesis during G2 Phase Is due to Checkpoint Activation.
    Sarah Lockhead, Alisa Moskaleva, Julia Kamenz, Yuxin Chen, Minjung Kang, Anay R Reddy, Silvia D M Santos, James E Ferrell Jr.
    Cell Rep. 2020 Jul 14;32(2):107901.  PubMedID: 32668239 PMCID: PMC7802425 DOI: 10.1016/j.celrep.2020.107901
  8. Rapidly dynamic host cell heterogeneity in bacterial adhesion governs susceptibility to infection by Listeria monocytogenes.
    Michelle Rengarajan, Julie A Theriot.
    Mol Biol Cell. 2020 Sep 1;31(19):2097-2106. Epub 2020 Jun 17.   PubMedID: 32583738 PMCID: PMC7530904 DOI: 10.1091/mbc.E19-08-0454
  9. The Clinical Drug Ebselen Attenuates Inflammation and Promotes Microbiome Recovery in Mice after Antibiotic Treatment for CDI.
    Megan Garland, Andrew J Hryckowian, Martina Tholen, Kristina Oresic Bender, William W Van Treuren, Sebastian Loscher, Justin L Sonnenburg, Matthew Bogyo.
    Cell Rep Med 2020 Apr 21;1(1):100005.  PubMedID: 32483557  PMCID: PMC7263476 DOI: 10.1016/j.xcrm.2020.100005
  10. Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity.
    Gretchen Ehrenkaufer, Pengyang Li, Erin E Stebbins, Monica M Kangussu-Marcolino, Anjan Debnath, Corin V White, Matthew S Moser, Joseph DeRisi, Jolyn Gisselberg, Ellen Yeh, Steven C Wang, Ana Hervella Company, Ludovica Monti, Conor R Caffrey, Christopher D Huston, Bo Wang, Upinder Singh.
    PLoS Negl Trop Dis. 2020 Mar 20;14(3):e0008150. eCollection 2020 Mar.   PubMedID: 32196500  PMCID: PMC7112225 DOI: 10.1371/journal.pntd.0008150
  11. HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis.
    Gongshi Bai, Chames Kermi, Henriette Stoy, Carl J Schiltz, Julien Bacal, Angela M Zaino, M Kyle Hadden, Brandt F Eichman, Massimo Lopes, Karlene A Cimprich.
    Mol Cell. 2020 Jun 18;78(6):1237-1251.e7. doi: 10.1016/j.molcel.2020.04.031. Epub 2020 May 21.   PubMedID: 32442397   PMCID: PMC7305998 DOI: 10.1016/j.molcel.2020.04.031
  12. CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.
    Kyuho Han, Sarah E Pierce, Amy Li, Kaitlyn Spees, Grace R Anderson, Jose A Seoane, Yuan-Hung Lo, Michael Dubreuil, Micah Olivas, Roarke A Kamber, Michael Wainberg, Kaja Kostyrko, Marcus R Kelly, Maryam Yousefi, Scott W Simpkins, David Yao, Keonil Lee, Calvin J Kuo, Peter K Jackson, Alejandro Sweet-Cordero, Anshul Kundaje, Andrew J Gentles, Christina Curtis, Monte M Winslow, Michael C Bassik.
    Nature. 2020 Apr;580(7801):136-141. Epub 2020 Mar 11.   PubMedID: 32238925   PMCID: PMC7368463 DOI: 10.1038/s41586-020-2099-x
  13. Stable Monomeric Insulin Formulations Enabled by Supramolecular PEGylation of Insulin Analogues.
    Caitlin L Maikawa, Anton A A Smith, Lei Zou, Catherine M Meis, Joseph L Mann, Matthew J Webber, Eric A Appel.
    Adv Ther (Weinh). 2020 Jan;3(1):1900094. Epub 2019 Dec 17.   PubMedID: 32190729 PMCID: PMC7079736  DOI: 10.1002/adtp.201900094
  14. An Excimer Clamp for Measuring Damaged-Base Excision by the DNA Repair Enzyme NTH1.
    Yong Woong Jun, David L Wilson, Anna M Kietrys, Elizabeth R Lotsof, Savannah G Conlon, Sheila S David, Eric T Kool.
    Angew Chem Int Ed Engl. 2020 May 4;59(19):7450-7455. Epub 2020 Mar 17.   PubMedID: 32109332 PMCID: PMC7180134  DOI: 10.1002/anie.202001516
  15. A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont.
    Catherine S Liou, Shannon J Sirk, Camil A C Diaz, Andrew P Klein, Curt R Fischer, Steven K Higginbottom, Amir Erez, Mohamed S Donia, Justin L Sonnenburg, Elizabeth S Sattely.
    Cell. 2020 Feb 20;180(4):717-728.e19.   PubMedID: 32084341 PMCID: PMC7515767  DOI: 10.1016/j.cell.2020.01.023
  16. Gut microbiota plasticity is correlated with sustained weight loss on a low-carb or low-fat dietary intervention.
    Jessica A Grembi, Lan H Nguyen, Thomas D Haggerty, Christopher D Gardner, Susan P Holmes, Julie Parsonnet.
    Sci Rep. 2020 Jan 29;10(1):1405.   PubMedID: 31996717 PMCID: PMC6989501  DOI: 10.1038/s41598-020-58000-y
  17. Structure of the neurotensin receptor 1 in complex with β-arrestin 1.
    Weijiao Huang, Matthieu Masureel, Qianhui Qu, John Janetzko, Asuka Inoue, Hideaki E Kato, Michael J Robertson, Khanh C Nguyen, Jeffrey S Glenn, Georgios Skiniotis, Brian K Kobilka.
    Nature. 2020 Mar;579(7798):303-308. Epub 2020 Jan 16.   PubMedID: 31945771 PMCID: PMC7100716  DOI: 10.1038/s41586-020-1953-1

2019

  1. Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia.
    Kangussu-Marcolino MM, Ehrenkaufer GM, Chen E, Debnath A, Singh U.
    Int J Parasitol Drugs Drug Resist. 2019 Dec;11:80-94. Epub 2019 Oct 22.   PubMedID: 31707263  PMCID: PMC6849155 DOI: 10.1016/j.ijpddr.2019.10.003
  2. Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1.
    Yu-Ki Tahara,  Anna M Kietrys, Marian Hebenbrock, Yujeong Lee, David L Wilson, Eric T Kool.
    ACS Chem Biol. 2019 Dec 20;14(12):2606-2615. Epub 2019 Oct 29.  PubMedID:31622553 PMCID: PMC7061906 DOI: 10.1021/acschembio.9b00490
  3. Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide.
    Nitta RT, Bolin S, Luo E, Solow-Cordero DE, Samghabadi P, Purzner T, Aujla PS, Nwagbo G, Cho YJ, Li G.
    Oncogene. 2019 Oct;38(42):6867-6879. Epub 2019 Aug 12. PubMedID: 31406250  PMCID: PMC6800621 DOI: 10.1038/s41388-019-0927-y,  Correction:  Oncogene. 2019 Oct 28. [Epub ahead of print] PubMedID: 31659253 DOI: 10.1038/s41388-019-1077-y.
  4. A high-throughput system to identify inhibitors of Candidatus Liberibacter asiaticus transcription regulators.
    Barnett MJ, Solow-Cordero DE, Long SR.
    Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):18009-18014. Epub 2019 Aug 19.  PubMedID: 31427509 PMCID: PMC6731658  DOI: 10.1073/pnas.1905149116
  5. Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes.
    Lauren N Booth, Travis J Maures, Robin W Yeo, Cindy Tantilert, Anne Brunet.
    Elife. 2019 Jul 8;8:e46418..  PubMedID: 31282863   PMCID: PMC6697445 DOI: 10.7554/eLife.46418
  6. SAR optimization studies on modified salicylamides as a potential treatment for acute myeloid leukemia through inhibition of the CREB pathway.
    Hee-Don Chae, Nick Cox, Samanta Capolicchio, Jae Wook Lee, Naoki Horikoshi, Sharon Kam, Andrew A Ng, Jeffrey Edwards, Tae-León Butler, Justin Chan, Yvonne Lee, Garrett Potter, Mark C Capece, Corey W Liu, Soichi Wakatsuki, Mark Smith, Kathleen M Sakamoto.
    Bioorg Med Chem Lett. 2019 Aug 15;29(16):2307-2315. Epub 2019 Jun 19.  PubMedID: 31253529   DOI: 10.1016/j.bmcl.2019.06.023
  7. Nuclear Factor Y (NF-Y) Modulates Encystation in Entamoeba via Stage-Specific Expression of the NF-YB and NF-YC Subunits.
    Dipak Manna, Upinder Singh.
    mBio. 2019 Jun 18;10(3):e00737-19.  PubMedID: 31213550   PMCID: PMC6581852 DOI: 10.1128/mBio.00737-19
  8. Small-Molecule Activators of Glucose-6-phosphate Dehydrogenase (G6PD) Bridging the Dimer Interface.
    Raub AG, Hwang S, Horikoshi N, Cunningham AD, Rahighi S, Wakatsuki S, Mochly-Rosen D.
    ChemMedChem. 2019 Jul 17;14(14):1321-1324. PubMedID: 31183991  PMCID: PMC6701841 DOI: 10.1002/cmdc.201900341
  9. Novel CMKLR1 Inhibitors for Application in Demyelinating Disease.
    Vineet Kumar, Melissa LaJevic, Mallesh Pandrala, Sam A Jacobo, Sanjay V Malhotra, Brian A Zabel.
    Sci Rep. 2019 May 9;9(1):7178.  PubMedID: 31073181 PMCID: PMC6509344 DOI: 10.1038/s41598-019-43428-8
  10. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.
    Lin Gan, Akiko Seki, Kimberle Shen, Harini Iyer, Kyuho Han, Arnold Hayer, Roy Wollman, Xuecai Ge, Jerry R Lin, Gautam Dey, William S Talbot, Tobias Meyer.
    Nat Cell Biol. 2019 May;21(5):614-626. Epub 2019 Apr 29.  PubMedID: 31036939 PMCID: PMC6649673 DOI: 10.1038/s41556-019-0321-6
  11. Luciferase-LOV BRET enables versatile and specific transcriptional readout of cellular protein-protein interactions.
    Christina K Kim, Kelvin F Cho, Min Woo Kim, Alice Y Ting.
    Elife. 2019 Apr 3;8:e43826.  PubMedID: 30942168 PMCID: PMC6447360 DOI: 10.7554/eLife.43826
  12. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.
    Gregor Bieri, Michel Brahic, Luc Bousset, Julien Couthouis, Nicholas J Kramer, Rosanna Ma, Lisa Nakayama, Marie Monbureau, Erwin Defensor, Birgitt Schüle, Mehrdad Shamloo, Ronald Melki, Aaron D Gitler.
    Acta Neuropathol. 2019 Jun;137(6):961-980. Epub 2019 Mar 29.   PubMedID: 30927072 PMCID: PMC6531417 DOI: 10.1007/s00401-019-01995-0
  13. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.
    Joe Z Zhang, Vittavat Termglinchan, Ning-Yi Shao, Ilanit Itzhaki, Chun Liu, Ning Ma, Lei Tian, Vicky Y Wang, Alex C Y Chang, Hongchao Guo, Tomoya Kitani, Haodi Wu, Chi Keung Lam, Kazuki Kodo, Nazish Sayed, Helen M Blau, Joseph C Wu.
    Cell Stem Cell. 2019 May 2;24(5):802-811.e5. doi: 10.1016/j.stem.2019.02.015. Epub 2019 Mar 14.   PubMedID: 30880024 PMCID: PMC6499654 DOI: 10.1016/j.stem.2019.02.015

2018

  1. Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity.
    Arun Sharma, Wesley L McKeithan, Ricardo Serrano, Tomoya Kitani, Paul W Burridge, Juan C Del Álamo, Mark Mercola, Joseph C Wu.
    Nat Protoc. 2018 Dec;13(12):3018-3041.  PubMedID: 30413796 PMCID: PMC6502639 DOI: 10.1038/s41596-018-0076-8
  2. An NAD+-dependent novel transcription factor controls stage conversion in Entamoeba.
    Manna D, Lentz CS, Ehrenkaufer GM, Suresh S, Bhat A, Singh U.
    Elife. 2018 Oct 30;7. pii: e37912.  PubMedID: 30375973 PMCID: PMC6207428 DOI: 10.7554/eLife.37912
  3. Dynamin impacts homology-directed repair and breast cancer response to chemotherapy.
    Chernikova SB, Nguyen RB, Truong JT, Mello SS, Stafford JH, Hay MP, Olson A, Solow-Cordero DE, Wood DJ, Henry S, von Eyben R, Deng L, Gephart MH, Aroumougame A, Wiese C, Game JC, Győrffy B, Brown JM.
    J Clin Invest. 2018 Dec 3;128(12):5307-5321. Epub 2018 Oct 29. PubMedID: 30371505 PMCID: PMC6264728   DOI: 10.1172/JCI87191
  4. Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.
    Hwang S, Mruk K, Rahighi S, Raub AG, Chen CH, Dorn LE, Horikoshi N, Wakatsuki S, Chen JK, Mochly-Rosen D.
    Nat Commun. 2018 Oct 2;9(1):4045. PubMedID: 30279493 PMCID: PMC6168459  DOI: 10.1038/s41467-018-06447-z
  5. High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites.
    Ehrenkaufer GM, Suresh S, Solow-Cordero D, Singh U.
    Front Cell Infect Microbiol. 2018 Aug 17;8:276. eCollection 2018.   PubMedID: 30175074 PMCID: PMC6107840  DOI: 10.3389/fcimb.2018.00276
  6. An intrinsic S/G2 checkpoint enforced by ATR.
    Saldivar JC, Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, Cortez D, Meyer T, Cimprich KA.
    Science. 2018 Aug 24;361(6404):806-810.  PubMedID: 30139873 PMCID: PMC6365305  DOI: 10.1126/science.aap9346
  7. FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension.
    Dannewitz Prosseda S, Tian X, Kuramoto K, Boehm M, Sudheendra D, Miyagawa K, Zhang F, Solow-Cordero D, Saldivar JC, Austin ED, Loyd JE, Wheeler L, Andruska A, Donato M, Wang L, Huebner K, Metzger RJ, Khatri P, Spiekerkoetter E.
    Am J Respir Crit Care Med. 2019 Jan 1;199(1):83-98. PubMedID: 30107138 PMCID: PMC6353016  DOI: 10.1164/rccm.201712-2553OC
  8. NKX3-1 is required for induced pluripotent stem cell reprogramming and can replace OCT4 in mouse and human iPSC induction.
    Thach Mai, Glenn J Markov, Jennifer J Brady, Adelaida Palla, Hong Zeng, Vittorio Sebastiano, Helen M Blau.
    Nat Genet. 2018 Mar;50(3):460-471. Epub 2018 Feb 19. PubMedID: 30013107 PMCID: PMC6101038 DOI: 10.1038/s41556-018-0136-x 
  9. Guanine Nucleotide Exchange Assay Using Fluorescent MANT-GDP.
    Tomoharu Kanie, Peter K Jackson.
    Bio Protoc. 2018 Apr 5;8(7):e2795. PubMedID: 29951569 PMCID: PMC6017992 DOI: 10.21769/BioProtoc.2795 
  10. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.
    Breslow DK, Hoogendoorn S, Kopp AR, Morgens DW, Vu BK, Kennedy MC, Han K, Li A, Hess GT, Bassik MC, Chen JK, Nachury MV.
    Nat Cell Biol. 2018 Aug;20(8):900-908. doi: 10.1038/s41556-018-0136-x. Epub 2018 Jul 16. PubMedID: 29459677  PMCID: PMC5862771  DOI: 10.1038/s41588-018-0054-7
  11. A Human Genome-wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation.
    Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC.
    Mol Cancer Res. 2018 May;16(5):745-753. Epub 2018 Feb 9. PubMedID: 29440447  PMCID: PMC5932228  DOI: 10.1158/1541-7786.MCR-17-0307.
  12. Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site.
    Gisselberg JE, Herrera Z, Orchard LM, Llinás M, Yeh E.
    Cell Chem Biol. 2018 Feb 15;25(2):185-193.e5. Epub 2017 Dec 21. PubMedID: 29276048 PMCID: PMC5820002  DOI: 10.1016/j.chembiol.2017.11.010
  13. Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand.
    Coronado M, Fajardo G, Nguyen K, Zhao M, Kooiker K, Jung G, Hu DQ, Reddy S, Sandoval E, Stotland A, Gottlieb RA, Bernstein D.
    Circ Res. 2018 Jan 19;122(2):282-295. Epub 2017 Dec 12.   PubMedID: 29233845  PMCID: PMC5775047 DOI: 10.1161/CIRCRESAHA.117.310725
  14. Ultrasensitive optical imaging with lanthanide lumiphores.
    Cho U, Riordan DP, Ciepla P, Kocherlakota KS, Chen JK, Harbury PB.
    Nat Chem Biol. 2018 Jan;14(1):15-21. Epub 2017 Nov 6. PubMedID: 29106397  PMCID: PMC5726931  DOI: 10.1038/nchembio.2513

2017

  1. Household triclosan and triclocarban effects on the infant and maternal microbiome.
    Ribado JV, Ley C, Haggerty TD, Tkachenko E, Bhatt AS, Parsonnet J.
    EMBO Mol Med. 2017 Dec;9(12):1732-1741. PubMedID: 29030459 PMCID: PMC5709730 DOI: 10.15252/emmm.201707882.
  2. Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor.
    Kim J, Shin JH, Chen CH, Cruz L, Farnebo L, Yang J, Borges P, Kang G, Mochly-Rosen D, Sunwoo JB.
    Oncotarget. 2017 Apr 10;8(32):52345-52356. eCollection 2017 Aug 8. PubMedID: 28881734 PMCID: PMC5581033 DOI: 10.18632/oncotarget.17017.
  3. Combinatorial Extracellular Matrix Microenvironments for Probing Endothelial Differentiation of Human Pluripotent Stem Cells.
    Hou L, Kim JJ, Wanjare M, Patlolla B, Coller J, Natu V, Hastie TJ, Huang NF.
    Sci Rep. 2017 Jul 26;7(1):6551. PubMedID: 28747756 PMCID: PMC5529516 DOI: 10.1038/s41598-017-06986-3.
  4. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
    Tomoharu Kanie, Keene Louis Abbott, Nancie Ann Mooney, Edward Douglas Plowey, Janos Demeter, Peter Kent Jackson.
    Dev Cell. 2017 Jul 10;42(1):22-36.e12. Epub 2017 Jun 15.   PubMedID: 28625565 PMCID: PMC5556974 DOI: 10.1016/j.devcel.2017.05.016
  5. Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength.
    Ho ATV, Palla AR, Blake MR, Yucel ND, Wang YX, Magnusson KEG, Holbrook CA, Kraft PE, Delp SL, Blau HM.
    Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6675-6684. Epub 2017 Jun 12. PubMedID: 28607093  PMCID: PMC5495271  DOI: 10.1073/pnas.1705420114
  6. Tethering Growth Factors to Collagen Surfaces Using Copper-Free Click Chemistry: Surface Characterization and in Vitro Biological Response.
    Lee HJ, Fernandes-Cunha GM, Putra I, Koh WG, Myung D.
    ACS Appl Mater Interfaces. 2017 Jul 19;9(28):23389-23399. Epub 2017 Jul 6. PubMedID: 28598594  DOI: 10.1021/acsami.7b05262
  7. Coupling between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants.
    Cunningham AD, Colavin A, Huang KC, Mochly-Rosen D.
    Cell Rep. 2017 Mar 14;18(11):2592-2599. PubMedID: 28297664 PMCID: PMC5396575 DOI: 10.1016/j.celrep.2017.02.048.
  8. Chemical Space Mimicry for Drug Discovery.
    Yuan W, Jiang D, Nambiar DK, Liew LP, Hay MP, Bloomstein J, Lu P, Turner B, Le QT, Tibshirani R, Khatri P, Moloney MG, Koong AC.
    J Chem Inf Model. 2017 Apr 24;57(4):875-882. Epub 2017 Apr 3. PubMedID: 28257191  PMCID: PMC5802964  DOI: 10.1021/acs.jcim.6b00754
  9. Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1.
    Child MA, Garland M, Foe I, Madzelan P, Treeck M, van der Linden WA, Oresic Bender K, Weerapana E, Wilson MA, Boothroyd JC, Reese ML, Bogyo M.
    MBio. 2017 Feb 28;8(1). pii: e02189-16. PubMedID: 28246362 PMCID: PMC5347346  DOI: 10.1128/mBio.02189-16
  10. Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.
    Bekerman E, Neveu G, Shulla A, Brannan J, Pu SY, Wang S, Xiao F, Barouch-Bentov R, Bakken RR, Mateo R, Govero J, Nagamine CM, Diamond MS, De Jonghe S, Herdewijn P, Dye JM, Randall G, Einav S.
    J Clin Invest. 2017 Apr 3;127(4):1338-1352. Epub 2017 Feb 27. PubMedID: 28240606 PMCID: PMC5373883 DOI: 10.1172/JCI89857.
  11. High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells.
    Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC.
    Sci Transl Med. 2017 Feb 15;9(377). pii: eaaf2584. PubMedID: 28202772  PMCID: PMC5409837  DOI: 10.1126/scitranslmed.aaf2584

2016

  1. Response to Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".
    Bender KO, Garland M, Bogyo M.
    Sci Transl Med. 2016 Dec 21;8(370):370tr2. PubMedID: 28003551  DOI: 10.1126/scitranslmed.aaf3410
  2. Screening of NCI-DTP library to identify new drug candidates for Borrelia burgdorferi.
    Pothineni VR, Wagh D, Babar MM, Inayathullah M, Watts RE, Kim KM, Parekh MB, Gurjarpadhye AA, Solow-Cordero D, Tayebi L, Rajadas J.
    J Antibiot (Tokyo). 2017 Mar;70(3):308-312. Epub 2016 Nov 9. PubMedID: 27826144  DOI: 10.1038/ja.2016.131
  3. Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy.
    Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM.
    Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13120-13125. Epub 2016 Oct 31. PubMedID: 27799523  PMCID: PMC5135315  DOI: 10.1073/pnas.1615340113
  4. An in vivo multiplexed small-molecule screening platform.
    Grüner BM, Schulze CJ, Yang D, Ogasawara D, Dix MM, Rogers ZN, Chuang CH, McFarland CD, Chiou SH, Brown JM, Cravatt BF, Bogyo M, Winslow MM.
    Nat Methods. 2016 Oct;13(10):883-9. PubMedID: 27617390 PMCID: PMC5088491 DOI: 10.1038/nmeth.3992. 
  5. Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage.
    Stork CT, Bocek M, Crossley MP, Sollier J, Sanz LA, Chédin F, Swigut T, Cimprich KA.
    Elife. 2016 Aug 23;5. pii: e17548. PubMedID: 27552054 PMCID: PMC5030092 DOI: 10.7554/eLife.17548
  6. Combinatorial extracellular matrix microenvironments promote survival and phenotype of human induced pluripotent stem cell-derived endothelial cells in hypoxia.
    Hou L, Coller J, Natu V, Hastie TJ, Huang NF.
    Acta Biomater. 2016 Oct 15;44:188-99. Epub 2016 Aug 4. PubMedID:27498178  PMCID: PMC5045796  DOI: 10.1016/j.actbio.2016.08.003
  7. Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction.
    Sclip A, Bacaj T, Giam LR, Südhof TC.
    PLoS One. 2016 Jun 27;11(6):e0158295. eCollection 2016. PubMedID:27348751  PMCID: PMC4922586  DOI: 10.1371/journal.pone.0158295
  8. A Multimodal Data Analysis Approach for Targeted Drug Discovery Involving Topological Data Analysis (TDA).
    Alagappan M, Jiang D, Denko N, Koong AC.
    Adv Exp Med Biol. 2016;899:253-68. PubMedID: 27325272 PMCID: PMC5519345  DOI: 10.1007/978-3-319-26666-4_15
  9. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Cytotoxic to Human Multiple Myeloma.
    Jiang D, Tam A, Alagappan M, Hay MP, Gupta A, Kozak M, Solow-Cordero DE, Lum PY, Denko N, Giaccia AJ, Le QT, Niwa M, Koong AC.
    Mol Cancer Ther. 2016 Sep;15(9):2055-65. Epub 2016 Jun 15. PubMedID: 27307600  PMCID: PMC5010920  DOI: 10.1158/1535-7163.MCT-15-1023
  10. Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening.
    Pothineni VR, Wagh D, Babar MM, Inayathullah M, Solow-Cordero D, Kim KM, Samineni A, Parekh M, Tayebi L, Rajadas J
    Drug Design, Development and Therapy. 2016 Apr 1; 10: 1307–1322. eCollection 2016. PubMedID: 27103785  PMCID: PMC4827596  DOI: 10.2147/DDDT.S101486  Press Release
  11. Small molecule screen for inhibitors of expression from canonical CREB response element-containing promoters.
    Mitton B, Hsu K, Dutta R, Tiu BC, Cox N, McLure KG, Chae HD, Smith M, Eklund EA, Solow-Cordero DE, Sakamoto KM.
    Oncotarget. 2016 Feb 23;7(8):8653-62.  PubMedID: 26840025  PMCID: PMC4890994  DOI: 10.18632/oncotarget.7085
  12. Development of RNA Interference Trigger-Mediated Gene Silencing in Entamoeba invadens.
    Suresh S, Ehrenkaufer G, Zhang H, Singh U.
    Infect Immun. 2016 Mar 24;84(4):964-975. Print 2016 Apr.  PubMedID: 26787723  PMCID: PMC4807475  DOI: 10.1128/IAI.01161-15
  13. The primate-specific noncoding RNA HPAT5 regulates pluripotency during human preimplantation development and nuclear reprogramming.
    Durruthy-Durruthy J, Sebastiano V, Wossidlo M, Cepeda D, Cui J, Grow EJ, Davila J, Mall M, Wong WH, Wysocka J, Au KF, Reijo Pera RA.
    Nat Genet. 2016 Jan;48(1):44-52. Epub 2015 Nov 23. PubMedID: 26595768  PMCID: PMC4827613  DOI: 10.1038/ng.3449

2015

  1. Oxygen regulation of breathing through an olfactory receptor activated by lactate.
    Chang AJ, Ortega FE, Riegler J, Madison DV, Krasnow MA.
    Nature. 2015 Nov 12;527(7577):240-4. PubMedID: 26560302  PMCID: PMC4765808  DOI: 10.1038/nature15721
  2. Plant stilbenes induce endoplasmic reticulum stress and their anti-cancer activity can be enhanced by inhibitors of autophagy.
    Papandreou I, Verras M, McNeil B, Koong AC, Denko NC.
    Exp Cell Res. 2015 Nov 15;339(1):147-53. Epub 2015 Oct 17. PubMedID: 26477823  PMCID: PMC4822495  DOI: 10.1016/j.yexcr.2015.10.014
  3. A small-molecule antivirulence agent for treating Clostridium difficile infection.
    Bender KO, Garland M, Ferreyra JA, Hryckowian AJ, Child MA, Puri AW, Solow-Cordero DE, Higginbottom SK, Segal E, Banaei N, Shen A, Sonnenburg JL, Bogyo M.
    Sci Transl Med. 2015 Sep 23;7(306):306ra148. Epub 2015 Sep 23. PubMedID: 26400909  PMCID: PMC6025901  DOI: 10.1126/scitranslmed.aac9103  Press Release
  4. Cell-Based High-Throughput Screening Identifies Rifapentine as an Inhibitor of Amyloid and Biofilm Formation in Escherichia coli.
    Maher MC, Lim JY, Gunawan C, Cegelski L.
    ACS Infect. Dis., 2015 Oct 9;1(10):460-8. Epub 2015 Aug 11. PubMedID: 27623312  DOI: 10.1021/acsinfecdis.5b00055
  5. Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease.
    Hwang S, Disatnik MH, Mochly-Rosen D.
    EMBO Mol Med. 2015 Oct;7(10):1307-26. PubMedID: 26268247  PMCID: PMC4604685  DOI: 10.15252/emmm.201505256
  6. Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension.
    Spiekerkoetter E, Sung YK, Sudheendra D, Bill M, Aldred MA, van de Veerdonk MC, Vonk Noordegraaf A, Long-Boyle J, Dash R, Yang PC, Lawrie A, Swift AJ, Rabinovitch M, Zamanian RT.
    Am J Respir Crit Care Med. 2015 Jul 15;192(2):254-7. PubMedID: 26177174  PMCID: PMC4532822  DOI: 10.1164/rccm.201411-2061LE
  7. Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.
    Chen CH, Cruz LA, Mochly-Rosen D.
    Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3074-9. Epub 2015 Feb 23. PubMedID: 25713355  PMCID: PMC4364197  DOI: 10.1073/pnas.1414657112  Press Release
  8. MicroRNA-200c Contributes to Injury From Transient Focal Cerebral Ischemia by Targeting Reelin.
    Stary CM, Xu L, Sun X, Ouyang YB, White RE, Leong J, Li J, Xiong X, Giffard RG.
    Stroke. 2015 Feb;46(2):551-6. Epub 2015 Jan 20. PubMedID: 25604249  PMCID: PMC4346276  DOI: 10.1161/STROKEAHA.114.007041
  9. A simple real-time assay for in vitro translation.
    Capece MC, Kornberg GL, Petrov A, Puglisi JD.
    RNA. 2015 Feb;21(2):296-305. Epub 2014 Dec 18. PubMedID: 25525154  PMCID: PMC4338355  DOI: 10.1261/rna.047159.114
  10. AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
    Neveu G, Ziv-Av A, Barouch-Bentov R, Berkerman E, Mulholland J, Einav S.
    J Virol. 2015 Apr;89(8):4387-404. Epub 2015 Feb 4. PubMedID: 25653444  PMCID: PMC4442395  DOI: 10.1128/JVI.02705-14

2014

  1. p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress.
    Yang ZJ, Kenzelmann Broz D, Noderer WL, Ferreira JP, Overton KW, Spencer SL, Meyer T, Tapscott SJ, Attardi LD, Wang CL.
    Cell Death Differ. 2014 Dec 4;159(6):1389-403. Epub 2014 Nov 20. PubMedID: 25501595  PMCID: PMC4329143  DOI: 10.1016/j.cell.2014.10.059
  2. Proteostatic Control of Telomerase Function through TRiC-Mediated Folding of TCAB1.
    Freund A, Zhong FL, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE.
    Cell. 2014 Dec 4;159(6):1389-403. Epub 2014 Nov 20.  PubMedID: 25467444  PMCID: PMC4329143  DOI: 10.1016/j.cell.2014.10.059
  3. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1.
    Gomes KM, Bechara LR, Lima VM, Ribeiro MA, Campos JC, Dourado PM, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC.
    Int J Cardiol. 2015 Jan 20;179:129-38. Epub 2014 Oct 23.  PubMedID: 25464432  PMCID: PMC4405147  DOI: 10.1016/j.ijcard.2014.10.140
  4. A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease.
    Graham KL, Zhang JV, Lewén S, Burke TM, Dang T, Zoudilova M, Sobel RA, Butcher EC, Zabel BA.
    PLoS One. 2014 Dec 1;9(12):e112925. eCollection 2014.  PubMedID: 25437209   PMCID: PMC4249827  DOI: 10.1371/journal.pone.0112925
  5. Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome.
    Emrich FC, Okamura H, Dalal AR, Penov K, Merk DR, Raaz U, Hennigs JK, Chin JT, Miller MO, Pedroza AJ, Craig JK, Koyano TK, Blankenberg FG, Connolly AJ, Mohr FW, Alvira CM, Rabinovitch M, Fischbein MP.
    Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):146-54. Epub 2014 Oct 30.  PubMedID: 25359856  DOI: 10.1161/ATVBAHA.114.304364
  6. Therapeutic targeting of BRCA1-mutated breast cancers with agents that activate DNA repair.
    Alli E, Solow-Cordero D, Casey SC, Ford JM.
    Cancer Res. 2014 Nov 1;74(21):6205-15. Epub 2014 Sep 12.  PubMedID: 25217519  PMCID: PMC4388430  DOI: 10.1158/0008-5472.CAN-14-1716
  7. Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors.
    Shin K, Lim A, Zhao C, Sahoo D, Pan Y, Spiekerkoetter E, Liao JC, Beachy PA.
    Cancer Cell. 2014 Oct 13;26(4):521-533.  PubMedID: 25314078  PMCID: PMC4326077  DOI: 10.1016/j.ccell.2014.09.001
  8. Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain.
    Zambelli VO, Gross ER, Chen CH, Gutierrez VP, Cury Y, Mochly-Rosen D.
    Sci Transl Med. 2014 Aug 27;6(251):251ra118. PubMedID: 25163478  PMCID: PMC4234033  DOI: 10.1126/scitranslmed.3009539   Press Release
  9. Arhgap36-dependent activation of Gli transcription factors.
    Rack PG, Ni J, Payumo AY, Nguyen V, Crapster JA, Hovestadt V, Kool M, Jones DT, Mich JK, Firestone AJ, Pfister SM, Cho YJ, Chen JK.
    Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11061-6. Epub 2014 Jul 14.  PubMedID: 25024229  PMCID: PMC4121843  DOI: 10.1073/pnas.1322362111
  10. Infection by Toxoplasma gondii specifically induces host c-Myc and the genes this pivotal transcription factor regulates.
    Franco M, Shastri AJ, Boothroyd JC.
    Eukaryot Cell. 2014 Apr;13(4):483-93. Epub 2014 Feb 14. PubMedID: 24532536  PMCID: PMC4000098  DOI: 10.1128/EC.00316-13
  11. Characterization of a fluorescent probe for imaging nitric oxide.
    Ghebremariam YT, Huang NF, Kambhampati S, Volz KS, Joshi GG, Anslyn EV, Cooke JP.
    J Vasc Res. 2014;51(1):68-79. Epub 2013 Dec 11.  PubMedID: 24335468  PMCID: PMC3927988  DOI: 10.1159/000356445
  12. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide.
    Ghebremariam YT, Erlanson DA, Cooke JP.
    J Pharmacol Exp Ther. 2014 Jan;348(1):69-76. Epub 2013 Oct 17.  PubMedID: 24135074  PMCID: PMC3868884  DOI: 10.1124/jpet.113.206847

2013

  1. Next-Generation NAMPT Inhibitors Identified by Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens.
    Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML.
    Chem Biol. 2013 Nov 21;20(11):1352-63. Epub 2013 Oct 31. PubMedID: 24183972  PMCID: PMC3881547  DOI: 10.1016/j.chembiol.2013.09.014 Press Release
  2. NEK8 Links the ATR-Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies.
    Choi HJ, Lin JR, Vannier JB, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ, Cimprich KA.
    Mol Cell. 2013 Aug 22;51(4):423-39.  PubMedID: 23973373  PMCID: PMC3790667  DOI: 10.1016/j.molcel.2013.08.006
  3. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion.
    Child MA, Hall CI, Beck JR, Ofori LO, Albrow VE, Garland M, Bowyer PW, Bradley PJ, Powers JC, Boothroyd JC, Weerapana E, Bogyo M.
    Nat Chem Biol. 2013 Oct;9(10):651-6. doi: 10.1038/nchembio.1315. Epub 2013 Aug 11.  PubMedID: 23934245  PMCID: PMC3832678  DOI: 10.1038/nchembio.1315
  4. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
    Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Dijke PT, Rabinovitch M.
    J Clin Invest. 2013 Aug 1;123(8):3600-13. Epub 2013 Jul 15. PubMedID: 23867624  PMCID: PMC3726153  DOI: 10.1172/JCI65592
  5. A c-Myc activation sensor-based high throughput drug screening identifies an anti-neoplastic effect of Nitazoxanide.
    Fan-Minogue H, Bodapati S, Solow-Cordero DE, Fan A, Paulmurugan R, Massoud T, Felsher DW, Gambhir SS.
    Mol Cancer Ther. 2013 Sep;12(9):1896-905. Epub 2013 Jul 3. PubMedID: 23825064  PMCID: PMC3772774  DOI: 10.1158/1535-7163.MCT-12-1243
  6. Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.
    Ghebremariam YT, LePendu P, Lee JC, Erlanson DA, Slaviero A, Shah NH, Leiper J, Cooke JP.
    Circulation. 2013 Aug 20;128(8):845-53. Epub 2013 Jul 3.  PubMedID: 23825361  PMCID: PMC3838201  DOI: 10.1161/CIRCULATIONAHA.113.003602
  7. A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth.
    Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT.
    Clin Cancer Res. 2013 Aug 15;19(16):4455-64. Epub 2013 Jun 28. PubMedID:23812668  PMCID: PMC3745542  DOI: 10.1158/1078-0432.CCR-13-0127
  8. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
    Penchala SC1, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, Graef IA, Alhamadsheh MM.
    Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. Epub 2013 May 28. PubMedID:23716704  PMCID: PMC3683741  DOI: 10.1073/pnas.1300761110
  9. Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts.
    Davila J, Chanda S, Ang CE, Südhof TC, Wernig M.
    J Neurosci Methods. 2013 Jun 15;216(2):104-9. Epub 2013 Apr 3. PubMedID:23562599  PMCID: PMC4009399  DOI: 10.1016/j.jneumeth.2013.03.020
  10. Oocyte-derived R-spondin2 promotes ovarian follicle development.
    Cheng Y, Kawamura K, Takae S, Deguchi M, Yang Q, Kuo C, Hsueh AJ.
    FASEB J. 2013 Jun;27(6):2175-84. Epub 2013 Feb 13. PubMedID: 23407710  PMCID: PMC3659360  DOI: 10.1096/fj.12-223412
  11. The incorporation of extracellular matrix proteins in protein polymer hydrogels to improve encapsulated beta-cell function.
    Beenken-Rothkopf LN1, Karfeld-Sulzer LS, Davis NE, Forster R, Barron AE, Fontaine MJ.
    Ann Clin Lab Sci. 2013 Spring;43(2):111-21. PubMedID: 23694784
  12. Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3.
    Tao GZ, Lehwald N, Jang KY, Baek J, Xu B, Omary MB, Sylvester KG.
    J Biol Chem. 2013 Jun 14;288(24):17214-24. Epub 2013 Apr 25.  PubMedID:23620592  PMCID: PMC3682526  DOI: 10.1074/jbc.M112.445965
  13. The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch.
    Yang Q, Ferrell JE Jr.
    Nat Cell Biol. 2013 May;15(5):519-25. Epub 2013 Apr 28. PubMedID:23624406  PMCID: PMC3728279  DOI: 10.1038/ncb2737
  14. Genetically encoded multispectral labeling of proteins with polyfluorophores on a DNA backbone.
    Singh V, Wang S, Kool ET.
    J Am Chem Soc. 2013 Apr 24;135(16):6184-91. Epub 2013 Apr 16.  PubMedID:23590213  PMCID: PMC3646636  DOI: 10.1021/ja4004393
  15. A critical role for AID in the initiation of reprogramming to induced pluripotent stem cells.
    Bhutani N, Decker MN, Brady JJ, Bussat RT, Burns DM, Corbel SY, Blau HM.
    FASEB J. 2013 Mar;27(3):1107-13. Epub 2012 Dec 4. PubMedID:23212122  PMCID: PMC3574289  DOI: 10.1096/fj.12-222125
  16. Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons.
    Krey JF, Paşca SP, Shcheglovitov A, Yazawa M, Schwemberger R, Rasmusson R, Dolmetsch RE.
    Nat Neurosci. 2013 Feb;16(2):201-9. Epub 2013 Jan 13. PubMedID:23313911   PMCID: PMC3568452  DOI: 10.1038/nn.3307
  17. CD271(+) bone marrow mesenchymal stem cells may provide a niche for dormant Mycobacterium tuberculosis.
    Das B, Kashino SS, Pulu I, Kalita D, Swami V, Yeger H, Felsher DW, Campos-Neto A.
    Sci Transl Med. 2013 Jan 30;5(170):170ra13. PubMedID: 23363977  PMCID: PMC3616630  DOI: 10.1126/scitranslmed.3004912

2012

  1. Identification and Characterization of a Potent Activator of P53-Independent Cellular Senescence Via a Small Molecule Screen for Modifiers of the Integrated Stress Response.
    Sayers CM, Papandreou I, Guttmann DM, Maas NL, Diehl JA, Witze ES, Koong AC, Koumenis C.
    Mol Pharmacol. 2013 Mar;83(3):594-604. Epub 2012 Dec 10.   PubMedID: 23229510 PMCID: PMC3583498 DOI: 10.1124/mol.112.081810
  2. SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
    Jang KY, Noh SJ, Lehwald N, Tao GZ, Bellovin DI, Park HS, Moon WS, Felsher DW, Sylvester KG.
    PLoS One. 2012;7(9):e45119. Epub 2012 Sep 14.   PubMedID: 23024800 PMCID: PMC3443243 DOI: 10.1371/journal.pone.0045119
  3. A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E-receptor interactions.
    Kim B, Tarchevskaya SS, Eggel A, Vogel M, Jardetzky TS.
    Anal Biochem. 2012 Dec 15;431(2):84-9. Epub 2012 Sep 18.   PubMedID: 22995065 PMCID: PMC3583350 DOI: 10.1016/j.ab.2012.09.010
  4. A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia.
    Dorn KV, Hughes CE, Rohatgi R.
    Dev Cell. 2012 Oct 16;23(4):823-35. Epub 2012 Sep 13.   PubMedID: 22981989 PMCID: PMC3586260 DOI: 10.1016/j.devcel.2012.07.004
  5. Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.
    Chan CT, Reeves RE, Geller R, Yaghoubi SS, Hoehne A, Solow-Cordero DE, Chiosis G, Massoud TF, Paulmurugan R, Gambhir SS.
    Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85. Epub 2012 Aug 15.   PubMedID: 22895790 PMCID: PMC3443147 DOI: 10.1073/pnas.1205459109
  6. β-Catenin regulates hepatic mitochondrial function and energy balance in mice.
    Lehwald N, Tao GZ, Jang KY, Papandreou I, Liu B, Liu B, Pysz MA, Willmann JK, Knoefel WT, Denko NC, Sylvester KG.
    Gastroenterology. 2012 Sep;143(3):754-64. Epub 2012 Jun 7.   PubMedID: 22684045 DOI: 10.1053/j.gastro.2012.05.048
  7. HIF-2α suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells.
    Das B, Bayat-Mokhtari R, Tsui M, Lotfi S, Tsuchida R, Felsher DW, Yeger H.
    Stem Cells. 2012 Aug;30(8):1685-95. PubMedID: 22689594 PMCID: PMC3584519 DOI: 10.1002/stem.1142
  8. C-type natriuretic peptide stimulates ovarian follicle development.
    Sato Y, Cheng Y, Kawamura K, Takae S, Hsueh AJ.
    Mol Endocrinol. 2012 Jul;26(7):1158-66. Epub 2012 May 17. PubMedID: 22595960 PMCID: PMC3385790 DOI: 10.1210/me.2012-1027
  9. Spatial positive feedback at the onset of mitosis.
    Santos SD, Wollman R, Meyer T, Ferrell JE Jr.
    Cell. 2012 Jun 22;149(7):1500-13. PubMedID: 22726437 PMCID: PMC3395376 DOI: 10.1016/j.cell.2012.05.028
  10. Development of a Dimethylarginine Dimethylaminohydrolase (DDAH) Assay for High-Throughput Chemical Screening.
    Ghebremariam YT, Erlanson DA, Yamada K, Cooke JP.
    J Biomol Screen. 2012 Jun;17(5):651-61. Epub 2012 Mar 29. PubMedID: 22460174 PMCID: PMC3606823 DOI: 10.1177/1087057112441521
  11. Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice.
    Ning S, Budas GR, Churchill EN, Chen CH, Knox SJ, Mochly-Rosen D.
    Radiat Res. 2012 Jul;178(1):69-74. Epub 2012 Mar 9. PubMedID: 22404739 PMCID: PMC3417825
  12. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
    Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK.
    Nature. 2012 Mar 18;484(7392):125-9. PubMedID: 22425997 PMCID: PMC3321072 DOI: 10.1038/nature10936
  13. Oxysterols are allosteric activators of the oncoprotein Smoothened.
    Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R.
    Nat Chem Biol. 2012 Jan 8;8(2):211-20. PubMedID: 22231273 PMCID: PMC3262054 DOI: 10.1038/nchembio.765

2011

  1. Neuropilins are positive regulators of Hedgehog signal transduction.
    Hillman RT, Feng BY, Ni J, Woo WM, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP.
    Genes Dev. 2011 Nov 15;25(22):2333-46. Epub 2011 Nov 3. Erratum in: Genes Dev. 2012 Mar 15;26(6):630.
    PubMedID: 22051878 PMCID: PMC3222900 DOI: 10.1101/gad.173054.111
  2. ALDH2 Activator Inhibits Increased Myocardial Infarction Injury by Nitroglycerin Tolerance.
    Sun L, Ferreira JC, Mochly-Rosen D.
    Sci Transl Med. 2011 Nov 2;3(107):107ra111.
    PubMedID: 22049071 MCID: PMC3547591 DOI: 10.1126/scitranslmed.3002067
  3. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.
    Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD.
    J Biol Chem. 2011 Dec 16;286(50):43486-94. Epub 2011 Oct 21.
    PubMedID: 22021038 PMCID: PMC3234859 DOI: 10.1074/jbc.M111.293597
  4. A Novel Aldehyde Dehydrogenase-3 Activator Leads to Adult Salivary Stem Cell Enrichment In Vivo.
    Banh A, Xiao N, Cao H, Chen CH, Kuo P, Krakow T, Bavan B, Khong B, Yao M, Ha C, Kaplan MJ, Sirjani D, Jensen K, Kong CS, Mochly-Rosen D, Koong AC, Le QT.
    Clin Cancer Res. 2011 Dec 1;17(23):7265-72. Epub 2011 Oct 13.
    PubMedID: 21998334 PMCID: PMC3544360 DOI: 10.1158/1078-0432.CCR-11-0179
  5. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.
    Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA.
    Sci Transl Med. 2011 Aug 24;3(97):97ra81.
    PubMedID: 21865539 PMCID: PMC3227540 DOI: 10.1126/scitranslmed.3002473
  6. Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality.
    Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan JU, Bouley DM, Graves EE, Denny WA, Hay MP, Giaccia AJ.
    Sci Transl Med. 2011 Aug 3;3(94):94ra70.
    PubMedID: 21813754 PMCID: PMC3683134 DOI: 10.1126/scitranslmed.3002394 Press Release SF Chronicle Front Page Article
  7. Wnt-β-catenin signaling protects against hepatic ischemia and reperfusion injury in mice.
    Lehwald N, Tao GZ, Jang KY, Sorkin M, Knoefel WT, Sylvester KG.
    Gastroenterology. 2011 Aug;141(2):707-18, 718.e1-5. Epub 2011 May 4.
    PubMedID: 21679710 PMCID: PMC4084974 DOI: 10.1053/j.gastro.2011.04.051
  8. Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.
    Hall CI, Reese ML, Weerapana E, Child MA, Bowyer PW, Albrow VE, Haraldsen JD, Phillips MR, Sandoval ED, Ward GE, Cravatt BF, Boothroyd JC, Bogyo M.
    Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10568-73. Epub 2011 Jun 13.
    PubMedID: 21670272 PMCID: PMC3127939 DOI: 10.1073/pnas.1105622108
  9. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells.
    Bonnet M, Flanagan JU, Chan DA, Lai EW, Nguyen P, Giaccia AJ, Hay MP.
    Bioorg Med Chem. 2011 Jun 1;19(11):3347-56. Epub 2011 Apr 24.
    PubMedID: 21561782 PMCID: PMC3115526 DOI: 10.1016/j.bmc.2011.04.042
  10. The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein.
    Lee C, Ma H, Hang JQ, Leveque V, Sklan EH, Elazar M, Klumpp K, Glenn JS.
    Virology.  2011 May 25;414(1):10-8. Epub 2011 Apr 22.
    PubMedID: 21513964 PMCID: PMC3096933 DOI: 10.1016/j.virol.2011.03.026
  11. Differentiating between fluorescence-quenching metal ions with polyfluorophore sensors built on a DNA backbone.
    Tan SS, Kim SJ, Kool ET.
    J Am Chem Soc. 2011 Mar 2;133(8):2664-71. Epub 2011 Feb 4.
    PubMedID: 21294558 PPMCID: PMC3045473 DOI: 10.1021/ja109561e
  12. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.
    Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ.
    Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1931-6. Epub 2011 Jan 13.
    PubMedID: 21233420 PMCID: PMC3033256 DOI: 10.1073/pnas.1011777108

2010

  1. PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells.
    Kim J, Koyanagi T, Mochly-Rosen D.
    Prostate. 2011 Jun 15;71(9):946-54. doi: 10.1002/pros.21310. Epub 2010 Nov 23.   PubMedID: 21541971 PMCID: PMC3544470 DOI: 10.1002/pros.21310
  2. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma.
    Papandreou I, Denko NC, Olson M, Van Melckebeke H, Lust S, Tam A, Solow-Cordero DE, Bouley DM, Offner F, Niwa M, Koong AC.
    Blood. 2011 Jan 27;117(4):1311-4. Epub 2010 Nov 16.   PubMedID: 21081713 PMCID: PMC3056474 DOI: 10.1182/blood-2010-08-303099
  3. Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.
    Vicent S, Chen R, Sayles LC, Lin C, Walker RG, Gillespie AK, Subramanian A, Hinkle G, Yang X, Saif S, Root DE, Huff V, Hahn WC, Sweet-Cordero EA.
    J Clin Invest. 2010 Nov 1;120(11):3940-52. Epub 2010 Oct 25.   PubMedID: 20972333 PMCID: PMC2965578 DOI: 10.1172/JCI44165
  4. The roles of cyclin A2, B1, and B2 in early and late mitotic events.
    Gong D, Ferrell JE Jr.
    Mol Biol Cell. 2010 Sep 15;21(18):3149-61. Epub 2010 Jul 21 PubMedID: 20660152 PMCID: PMC2938381 DOI: 10.1091/mbc.E10-05-0393
  5. Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.
    Yi-Ching Ong, Michael L Reese, John C Boothroyd.
    J Biol Chem. 2010 Sep 10;285(37):28731-40. Epub 2010 Jul 12. PubMedID: 20624917 PMCID: PMC2937901 DOI: 10.1074/jbc.M110.112359
  6. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors.
    Einav S, Sobol HD, Gehrig E, Glenn JS.
    J Infect Dis. 2010 Jul 1;202(1):65-74 PubMedID: 20486856 PMCID: PMC3008401 DOI: 10.1086/653080
  7. A small molecule inhibits HCV replication and alters NS4B's subcellular distribution.
    Bryson PD, Cho NJ, Einav S, Lee C, Tai V, Bechtel J, Sivaraja M, Roberts C, Schmitz U, Glenn JS.
    Antiviral Res. 2010 Jul;87(1):1-8. Epub 2010 Apr 2 PubMedID: 20363257 PMCID: PMC3909674 DOI: 10.1016/j.antiviral.2010.03.013
  8. Identification of a Class of HCV Inhibitors Directed Against the Nonstructural Protein NS4B.
    Cho NJ, Dvory-Sobol H, Lee C, Cho SJ, Bryson P, Masek, M, Elazar M, Frank CW, Glenn JS.
    Sci Transl Med 2010 Jan 20;2(15):15ra6.   PubMedID: 20371471 PMCID: PMC3025298 DOI: 10.1126/scitranslmed.3000331
    Press Release
  9. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.
    Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD.
    Nature Structural & Molecular Biology. 2010; Feb;17(2):159-64. Epub 2010 Jan 10.   PubMedID: 20062057 PMCID: PMC2857674 DOI: 10.1038/nsmb.1737
    Press Release
  10. 4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death.
    Hay MP, Turcotte S, Flanagan JU, Bonnet M, Chan DA, Sutphin PD, Nguyen P, Giaccia AJ, Denny WA.
    J Med Chem. 2010 Jan 28;53(2):787-97. PubMedID: 19994864 PMCID: PMC2838715 DOI: 10.1021/jm901457w

2009

  1. Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.
    Budas GR, Disatnik, MH, Chen CH, Mochly-Rosen D.
    J Mol Cell Cardiol. 2010 Apr;48(4):757-64. Epub 2009 Nov 11.    PubMedID: 19913552 PMCID: PMC2837767 DOI: 10.1016/j.yjmcc.2009.10.030
  2. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
    Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK.
    Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7. Epub 2009 Aug 5.   PubMedID: 19666565 PMCID: PMC2721821 DOI: 10.1073/pnas.0907134106
  3. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. 
    Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA.
    Mol Cell. 2009 Jul 31; 35 (2): 228-39. PubMedID: 19647519 PMCID: PMC2772893 DOI: 10.1016/j.molcel.2009.06.021
  4. Molecular imaging of phosphorylation events for drug development. 
    Chan CT, Paulmurugan R, Reeves RE, Solow-Cordero D, Gambhir SS.
    Mol Imaging Biol. 2009 May-Jun;11(3):144-58. Epub 2008 Dec 2. PubMedID: 19048345 PMCID: PMC4154800 DOI: 10.1007/s11307-008-0187-7
  5. The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation. 
    Elazar M, Liu M, McKenna SA, Liu P, Gehrig EA, Puglisi JD, Rossignol JF, Glenn JS.
    Gastroenterology. 2009 Nov;137(5):1827-35. Epub 2009 Aug 4. PubMedID: 19664635 DOI: 10.1053/j.gastro.2009.07.056
  6. Noninflammatory gluten peptide analogs as biomarkers for celiac sprue.
    Bethune MT, Crespo-Bosque M, Bergseng E, Mazumdar K, Doyle L, Sestak K, Sollid LM, Khosla C.
    Chem Biol. 2009 Aug 28;16(8):868-81. PubMedID: 19716477 PMCID: PMC3721637 DOI: 10.1016/j.chembiol.2009.07.009
  7. Converse conformational control of smoothened activity by structurally related small molecules.
    Yang H, Xiang J, Wang N, Zhao Y, Hyman J, Li S, Jiang J, Chen JK, Yang Z, Lin S.
    J Biol Chem. 2009 Jul 31;284(31):20876-84. Epub 2009 Apr 14.
    PubMedID: 19366682 PMCID: PMC2742853 DOI: 10.1074/jbc.M807648200
  8. Interferon-gamma released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides.
    Bethune MT, Siegel M, Howles-Banerji S, Khosla C.
    J Pharmacol Exp Ther. 2009 May;329(2):657-68. Epub 2009 Feb 13.   PubMedID: 19218531 PMCID: PMC2672868 DOI: 10.1124/jpet.108.148007
  9. Defective repair of oxidative dna damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase.
    Alli E, Sharma VB, Sunderesakumar P, Ford JM.
    Cancer Res. 2009 Apr 15;69(8):3589-96. Epub 2009 Apr 7.   PubMedID: 19351835 PMCID: PMC2681413 DOI: 10.1158/0008-5472.CAN-08-4016
  10. Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.
    Rohatgi R, Milenkovic L, Corcoran RB, Scott MP.
    Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3196-201. Epub 2009 Feb 13.   PubMedID: 19218434 PMCID: PMC2642660 DOI: 10.1073/pnas.0813373106
  11. Viral infection of human progenitor and liver-derived cells encapsulated in three-dimensional PEG-based hydrogel.
    Nam-Joon Cho, Menashe Elazar, Anming Xiong, Wonjae Lee, Eric Chiao, Julie Baker, Curtis W Frank, Jeffrey S Glenn.
    Biomed Mater. 2009 Feb;4(1):011001. Epub 2008 Nov 4.   PubMedID: 18981544 DOI: 10.1088/1748-6041/25/1/011001

2008

  1. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.
    Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D.
    Science. 2008 Sep 12;321(5895):1493-5.   PubMedID: 18787169 PMCID: PMC2741612 DOI: 10.1126/science.1158554 Press Release
  2. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy.
    Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ.
    Cancer Cell. 2008 Jul 8; 14 (1): 90-102. PubMedID: 18598947 PMCID: PMC2819422 DOI: 10.1016/j.ccr.2008.06.004
    Press Release
  3. Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death.
    Turcotte S, Sutphin PD, Giaccia AJ.
    Autophagy. 2008 Oct;4(7):944-6. Epub 2008 Oct 13. PubMedID: 18769110 PMCID: PMC2803726
  4. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.
    Einav S, Gerber D, Bryson PD, Sklan EH, Elazar M, Maerkl SJ, Glenn JS, Quake SR.
    Nat Biotechnol. 2008 Sep 26 (9): 1019-27. PubMedID: 18758449 PMCID: PMC4110250 DOI: 10.1038/nbt.1490
    Press Release
  5. Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF. 
    Pomerening JR, Ubersax JA, Ferrell JE.
    Mol Biol Cell. 2008 Aug;19(8):3426-41. Epub 2008 May 14.   PubMedID: 18480403 PMCID: PMC2488275 DOI: 10.1091/mbc.e08-02-0172
  6. GLUT1 and GLUT9 as major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor.
    Takanaga H, Chaudhuri B, Frommer WB.
    Biochim Biophys Acta. 2008 Apr;1778(4):1091-9.  Epub 2007 Dec 14.   PubMedID: 18177733 PMCID: PMC2315637 DOI: 10.1016/j.bbamem.2007.11.015

2007

  1. siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake.
    Galvez T, Teruel MN, Heo WD, Jones JT, Kim ML, Liou J, Myers JW, Meyer T.
    Genome Biol. 2007;8(7):R142. PubMedID: 17640392 PMCID: PMC2323231 DOI: 10.1186/gb-2007-8-7-r142
  2. Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1.
    Gong D, Pomerening JR, Myers JW, Gustavsson C, Jones JT, Hahn AT, Meyer T, Ferrell JE.
    Curr Biol. 2007; 17 (1): 85-91. PubMedID: 17208191 PMCID: PMC1830184 DOI: 10.1016/j.cub.2006.11.066
  3. A transgenic mouse model for high content, cell cycle phenotype screening in live primary cells.
    Burney RO, Lee AI, Leong DE, Jones JT, Hahn AT, Meyer T, Yao MW.
    Cell Cycle. 2007 Sep 15;6(18):2276-83. Epub 2007 Jul 9. PubMedID: 17881898 DOI: 10.4161/cc.6.18.4718
  4. TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.
    Sklan EH, Serrano RL, Einav S, Pfeffer SR, Lambright DG, Glenn JS.
    Biol Chem. 2007 Dec 14;282(50):36354-61. Epub 2007 Sep 27. PubMedID: 17901050 DOI: 10.1074/jbc.M705221200

2006

2005

  1. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.
    Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE, Meyer T.
    Curr Biol. 2005 Jul 12;15(13):1235-41.. PubMedID: 16005298 PMCID: PMC3186072 DOI: 10.1016/j.cub.2005.05.055
    Stanford Medicine: Anatomy of an Experiment Article
  2. The unfolded protein response: a novel component of the hypoxic stress response in tumors.
    Feldman DE, Chauhan V, Koong AC.
    Mol Cancer Res. 2005; 3 (11): 597-605. PubMedID: 16317085 DOI: 10.1158/1541-7786.MCR-05-0221

The HTSKC is located in the Sarafan ChEM-H Building Room W008 and CCSR, Room 0133-North Wing, between the Transgenic Research Center and the Stanford Genomics Facility.

For Directions to the HTSKC, see our Contact page.

HTSKC iLAB Page for HTSKC registration, room access, and to see equipment Calendars.