Clinical Research

Our
Clinical
Research

Serum and cellular biomarkers to predicting disease activity in MS and Neuromyelitis optica

Blood and imaging biomarkers to predict disease activity in MS

Cognitive impairment in MS

The Collaborative International Research in Clinical and Longitudinal Experience for Neuromyelitis Optica (NMO) Studies (CIRCLES)

Neuromyelitis
Optica
(NMO)

Is an inflammatory demyelinating disorder of the Central Nervous System (CNS) primarily affecting the optic nerve and spinal cord. Individuals suffering from NMO mainly present with vision impairment, weakness and paralysis, and bladder and bowel problems. NMO patients most often have relapses and progressive neurologic disability.

Collaborative
International
Research

The Collaborative International Research in Clinical and Longitudinal Experience for Neuromyelitis Optica (NMO) Studies (CIRCLES) is a study that aims to create an open-access repository of data and samples from participants with NMO and from control participants.  These materials are intended to be used in research to better understand:

  • NMO Pathogenesis,
  • Clinical Course
  • Impact of Therapy

Results of these studies may identify:

  • The etiology and risk factors
  • Biomarkers for disease progression
  • Treatment outcomes to guide development of novel therapies

Findings may also facilitate future research and clinical trials to investigate specific hypotheses related to NMO and to improve the lives of individuals suffering from NMO.

Clinical Trials

CorEvitas SPHERES (Synergy of Prospective Health & Experimental Research for Emerging Solutions) Registry for Neuromyelitis Optica Spectrum Disorder (NMOSD)
NCT04886492
PI: May Han, MD
Research Coordinator: Tara Sarkar, tarats@stanford.edu
Status: Enrolling

A Randomized, Double-blind, Placebo-Controlled, Multicenter, Phase 3, Pivotal Study with an Open-Label Extension Period to Evaluate the Efficacy and Safety of Rozanlixizumab in Adult Participants with Myelin Oligodentrocyte Glycoprotein (MOG) antibody-associated disease (MOG-AD)
NCT05063162
PI: May Han, MD
Research Coordinator: Tara Sarkar, tarats@stanford.edu
Status: Enrolling

Clinical Trials Contact:

Tara Sarkar
Research Coordinator
tarats@stanford.edu

Clinical Research Questions?

For more information regarding the Han Lab Clinical Reseach:

Tara Sarkar
Research Coordinator
tarats@stanford.edu

Guthy-Jackson Charitable Foundation

 

This work is funded by the Guthy-Jackson Charitable Foundation for NMO research.

We are currently recruiting participants for the CIRCLES study.

Participants will answer patient questionnaires and donate blood samples.