Publications
Selected Publications
1. Lu G*, Hickey JW, Naveed A, Haist M, Forgo E, Baertsch MA, Mani L, Rovira-Clave X, Finegersh A, Goltsev Y, Caraccio C, van den Berg NS, Hom M, Kong CS, Lui NS, Colevas AD, Poultsides GA, Thurber GM, West RB, Nolan GP*, Rosenthal EL*. “Spatial Pharmaco-Biology Reveals that Cancer-Associated Fibroblasts and Extracellular Matrix Act as Barriers to Targeted Therapy in Head and Neck Cancer.” 2024 (*Co-Corresponding; Under Revision)
2. Matusiak M, Hickey JW, van IJzendoorn DGP, Lu G, Kidzinski L, Zhu S, Colburg DRC, Luca B, Phillips DJ, Brubaker SW, Charville GW, Shen J, Loh KM, Okwan-Duodu DK, Nolan GP, Newman AM, West RB, van de Rijn M. Spatially Segregated Macrophage Populations Predict Distinct Outcomes In Colon Cancer. Cancer Discov. 2024. PMID: 38552005.
3. Lu G, Baertsch MA, Hickey JW, Goltsev Y, Rech AJ, Mani L, Forgo E, Kong C, Jiang SZ, Nolan GP*, Rosenthal EL*. “RAPID: a real-time GPU-accelerated processor for highly multiplexed fluorescence imaging microscopy data.” Front Immunol. 2022;13:981825. (*Co-Corresponding)
4. Fuswanto W, Nolan GP, Lu G*. “Highly multiplexed spatial profiling with CODEX: bioinformatic analysis and application in human disease. Semin Immunopathol.” 2022:1–13 (*Corresponding; Invited Review)
5. Lu G, Nishio N, van den Berg NS, Martin BA, Fakurnejad S, van Keulen S, Colevas AD, Thurber GM, Rosenthal EL. “Co-administered antibody improves penetration of antibody-dye conjugate into human cancers with implications for antibody-drug conjugates.” Nat Commun. 2020;11(1):5667. (*Editors’ Highlights; Editors’ Choice-Sci Transl Med)
6. Lu G, Rosenthal EL. “Translating a fluorescent DNA-repair inhibitor”. Nat Biomed Eng. 2020;4(3):247-249.
7. Lu G, Fakurnejad S, Martin BA, van den Berg NS, van Keulen S, Nishio N, Zhu AJ, Chirita SU, Zhou Q, Gao RW, Kong CS, Fischbein N, Penta M, Colevas AD, Rosenthal EL. “Predicting therapeutic antibody delivery into human head and neck cancers.” Clin Cancer Res. 2020;26(11):2582-2594. (*Journal Cover)
8. Lu G, van den Berg NS, Martin BA, Nishio N, Hart ZP, van Keulen S, Fakurnejad S, Chirita SU, Raymundo RC, Yi G, Zhou Q, Fisher GA, Rosenthal EL, Poultsides GA. “Tumour-specific fluorescence-guided surgery for pancreatic cancer using panitumumab-IRDye800CW: a phase 1 single-centre, open-label, single-arm, dose-escalation study.” Lancet Gastroenterol Hepatol. 2020;5(8):753-764. (*Accompanied Editorial)
9. Lu G, Little JV, Wang X, Zhang H, Patel MR, Griffith CC, El-Deiry MW, Chen AY, Fei B. “Detection of head and neck cancer in surgical specimens using quantitative hyperspectral imaging.” Clin Cancer Res. 2017;23(18):5426-5436.
10. Lu G, Wang D, Qin X, Muller S, Little JV, Wang X, Chen AY, Chen G, Fei B. “Histopathology feature mining and association with hyperspectral imaging for the detection of squamous neoplasia.” Sci Rep. 2019;9(1):17863.
11. Lu G, Wang D, Qin X, Muller S, Wang X, Chen AY, Chen ZG, Fei B. “Detection and delineation of squamous neoplasia with hyperspectral imaging in a mouse model of tongue carcinogenesis.” J Biophotonics. 2018;11(3).
12. Lu G, Wang D, Qin X, Halig L, Muller S, Zhang H, Chen A, Pogue BW, Chen ZG, Fei B. “Framework for hyperspectral image processing and quantification for cancer detection during animal tumor surgery.” J Biomed Opt. 2015;20(12):126012.
13. Lu G, Halig L, Wang D, Qin X, Chen ZG, Fei B. “Spectral-spatial classification for noninvasive cancer detection using hyperspectral imaging.” J Biomed Opt. 2014;19(10):106004.
14. Lu G, Fei B. “Medical hyperspectral imaging: a review”. J Biomed Opt. 2014;19(1):10901. (*Top Downloaded Papers)
15. Pike R*, Lu G*, Wang D, Chen ZG, Fei B. “A minimum spanning forest-based method for noninvasive cancer detection with hyperspectral imaging.” IEEE Trans Biomed Eng. 2016;63(3):653-63. (*Equal Contribution)
16. Halicek M, Lu G, Little JV, Wang X, Patel M, Griffith CC, El-Deiry MW, Chen AY, Fei B. “Deep convolutional neural networks for classifying head and neck cancer using hyperspectral imaging.” J Biomed Opt. 2017 1;22(6):60503.
17. Kapoor S*, Lu G*, van den Berg NS, Krishnan Giri, Pei J, Zhou Q, Martin BA, Baik F, Rosenthal EL, Nisho N, “Effect of formalin fixation for near-infrared fluorescence imaging with an antibody-dye conjugate in head and neck cancer patients.” Mol Imaging Biol. 2021;23(2):270-276. (*Equal Contribution)
18. Hart ZP, Nishio N, Krishnan G, Lu G, Zhou Q, Fakurnejad S, Wormald PJ, van den Berg NS, Rosenthal EL, Baik FM. “Endoscopic fluorescence-guided surgery for sinonasal cancer using an antibody-dye conjugate.” Laryngoscope. 2019; 130(12):2811-2817. (*Journal Cover)
19. Fei B, Lu G, Wang X, Zhang H, Little JV, Patel MR, Griffith CC, El-Diery MW, Chen AY. “Label-free reflectance hyperspectral imaging for tumor margin assessment: a pilot study on surgical specimens of cancer patients.” J Biomed Opt. 2017;22(8):1-7.
20. Guo R, Lu G, Qin B, Fei B. “Ultrasound Imaging Technologies for Breast Cancer Detection and Management: A Review.” Ultrasound Med Biol. 2018;44(1):37-70.
21. Ma L, Lu G, Wang D, Qin X, Chen ZG, Fei B. “Adaptive deep learning for head and neck cancer detection using hyperspectral imaging.” Vis Comput Ind Biomed Art. 2019;2(1):18.
22. Lee Y. J., Krishnan G., Nishio N., van den Berg N. S., Lu G., Martin B. A., van Keulen S., Colevas A. D., Kapoor S., Liu J. T., Rosenthal E. L. “Intraoperative Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma.” The Laryngoscope. 2021; 131 (3): 529–34.
23. Krishnan G, van den Berg NS, Nishio N, Juniper G, Pei J, Zhou Q, Lu G, Lee YJ, Ramos K, Iagaru AH, Baik FM, Colevas AD, Martin BA, Rosenthal EL. “Metastatic and sentinel lymph node mapping using intravenously delivered Panitumumab-IRDye800CW.” Theranostics. 2021;11(15):7188-7198.
24. Nishio N, van den Berg NS, van Keulen S, Martin BA, Fakurnejad S, Teraphongphom N, Chirita SU, Oberhelman NJ, Lu G, Horton CE, Kaplan MJ, Divi V, Colevas AD, Rosenthal EL. “Optical molecular imaging can differentiate metastatic from benign lymph nodes in head and neck cancer.” Nat Commun. 2019;10(1):5044.