Welcome to Guolan Lu Laboratory
Spatial AI for Human Disease Ecosystems
We develop and integrate spatial omics, biomedical imaging, and artificial intelligence to map, model, and reprogram how cells, matrix, and therapies are organized in human tissues. Our goal is to reveal how tissue architecture shapes biological function, disease progression, and therapeutic response and to translate these insights toward disease interception and curative therapy.
Latest News
June 2026
We are excited to announce that our manuscript is online in Nature Biotechnology, "Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors". This work introduces a single-cell spatial pharmacobiology framework to map therpeutic antibody delivery, target engagement, and stromal barriers in intact human tumors.
July 2026
Our recent publication in Nature Biotechnology is highlighted by Stanford Medicine News.
Antibody therapies show limited success in solid tumors. A new imaging technique developed at Stanford Medicine that locates antibodies at subcellular resolution in human tumors hints at why.