Perioperative organ injury

Perioperative organ injury are acute organ injuries that occur while undergoing surgery including acute myocardial infarction, stroke, and gut, lung, and kidney injury.  Based on our long-standing interest in studying how anesthetics and analgesics impact organ injury, particularly cardiac injury, we are developing new models and cutting-edge strategies in the basic science laboratory to better understand how genetic variants, particularly in Asians, impact perioperative organ injury.  Understanding how these genetic differences in Asians may alter organ damage can unlock novel treatment strategies for all ethnicities to reduce organ injury occurring during surgery.

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We are also using our background in anesthesiology and organ injury together with cutting-edge technology to develop real-time monitoring systems for organ injury in humans to be used for patients having surgery.


Novel analgesics

We are currently developing novel analgesics for pain control through strategies including targeting protein-protein interactions and boosting reactive aldehyde metabolism.  We hope these strategies may replace prescribing opioids to treat pain.

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Using our background in rodent experimental models of the cardiopulmonary system, we are also studying how e-cigarette exposure, when coupled with genetics may affect the cardiopulmonary system.

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