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Lab News

LOXHD1 is a crucial component of the auditory mechanotransduction machinery

We published our discovery of an additional component of the auditory mechanotransduction machinery in Nature Communications.

The protein LOXHD1, that we had previously discovered as causing hearing loss in mice and human when mutated, is critical to maintain the auditory channels at the tip of stereocilia, where the force is received. Contact Pr. Nicolas Grillet for more information at ngrillet@stanford.edu.

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A revolution for in vivo protein localization

We published in Nature Communications a new technique to localize proteins close to the plasma membrane with nanoscale resolution by Scanning Electron Microscopy. We discovered the presence of a nanoscale ring at the tip of stereocilia. 

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LOXHD1 and cancer

Our collaborative work with D. Asangani, University of Pennsylvania is published in Cell Reports.We show that LOXHD1 is overexpressed in a rare pediatric cancer and drives its malignancy.

Congrats to the team and Pei who contributed to the discovery!

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