Gerald Grant Lab

Blood-Brain Barrier Translational Laboratory

Our lab focuses on understanding the role of the vasculature in the brain and brain tumors and ways to manipulate the blood-brain and blood-tumor barriers to enhance drug delivery to brain tumors in children. Although we employ a multitude of both in vitro and in vivo techniques to study these barriers, we focus on in vivo multi-photon microscopy imaging which provides cellular resolution to study these changes in a temporal and quantitative fashion. One of the main mechanisms we have to manipulate the blood-brain barrier is siRNA to claudin-5. Claudin-5 is an endothelial tight junction protein that highly expressed in the brain vasculature and using the siRNA to claudin-5 we can open the barrier in a reversible manner that allows enhanced drug delivery to the brain while not increasing side effects throughout the rest of the body.

Department of Neurosurgery

The Gerald Grant lab is part of the Department of Neurosurgery.