2014 - 2017 Publications

Ouyang YB, Ning SC, Adler JR, MacIver B, Knox SJ, Giffard RG. Alteration of interneuron immunoreactivity and autophagic activity in rat hippocampus after single high-dose whole-brain irradiation. Cureus. 2017 June 30. 9(6): e1414. doi: 10.7759/cureus.1414

Bell JD, Cho JE, Giffard RG. MicroRNA Changes in Preconditioning-Induced Neuroprotection. Translational Stroke Research. 2017 June 23. doi: 10.1007/s12975-017-0547-1 

Stary CM, Xu LJ, Li L, Sun XY, Ouyang YB, Xiong XX, Zhao J, Giffard RG. Inhibition of miR-181a Protects Female Mice from Transient Focal Cerebral Ischemia by Targeting Astrocyte Extrogen Receptor-α. Molecular and Cellular Neuroscience. 2017 May 15. 82; 118-125. doi: 10.1016/j.mcn.2017.05.004. 

Dagne BA, Sunay MK, Cayla NS, Ouyang YB, Knox SJ, Giffard RG. High dose gamma radiation selectively reduces GABAA-slow inhibition. Cureus. 2017 March 4. ;9(3):e1076. doi: 10.7759/cureus.1076.

  • Chang, J, Mancuso MR, Maier-Albers C, Liang, X, Yuki K, Yang L, Kwong JW, Wang J, Rao V, Vallon M, Kosinski C, Zhang H, Mah AT, Xu LJ, Li L, Gholamin S, Reyes TF, Li R, Kuhnert F, Han X, Yuan J, Chiou SH, Brettman AD, Wang Z, Tracy L, Corney DC, Cheshier SH, Shortliffe LD, Wu X, Snyder M, Chan P, Giffard RG, Chang HY, Andreasson K, Kuo CJ. Grp124 is essential for pathologic blood-brain barrier integrity. Nature Medicine. 2017 March. doi: 10.1038/nm.4309
  • Voloboueva LA, Sun X, Xu L, Ouyang YB, Giffard RG. Distinct effects of miR-210 reduction on neurogenesis: increased neuronal survival of inflammation but reduced proliferation associated with mitochondrial enhancement. J Neurosci. 2017 Feb 10: 1777-16. doi: 10.1523/JNEUROSCI.1777-16.2017. Epub 2017 Feb 10. PMID: 28188219  
  • Stary CM, Sun X, Ouyang Y, Li L, Giffard RG.  miR-29a differentially regulates cell survival in astrocytes from cornu ammonis 1 and dentate gyrus by targeting VDAC1. Mitochondrion. 2016 Sep;30:248-54. doi: 10.1016/j.mito.2016.08.013. Epub 2016 Aug 21.
  • Stary CM, Sun X., Giffard RG. Astrocytes Protect against Isoflurane Neurotoxicity by Buffering Pro-Brain-Derived Neurotrophic Factor. Anesthesiology. 123(4):810-9, 2015.
  • Sun X, Voloboueva L, Stary CM, Giffard RG. Physiologically normal 5% O2 Supports Neuronal Differentiation and Resistance to Inflammatory Injury in Neural Stem Cell Cultures. Journal of Neuroscience Research. 93(11):1703-12, 2015.
  • Xiong X, Xu LJ, Wei L, White RE, Ouyang YB, Giffard RG. IL-4 is required for Sex Differences in Vulnerability to Focal Ischemia in Mice. Stroke 46(8):2271-6, 2015.
  • Stary CM, Xu L, Sun X, Ouyang YB, White RE, Leong J, Li J, Xiong X, Giffard RG. MicroRNA-200c contributes to injury from transient focal cerebral ischemia by targeting Reelin. Stroke 46(2): 551-6, 2015.
  • Ouyang YB, Stary CM, White RE, Giffard RG. The Use of microRNAs to Modulate Redox and Immune Response to Stroke. Antioxidants & Redox Signaling. 22(2): 187-202, 2015.
  • Xu LJ, Ouyang YB, Xiong X, Stary CM, Giffard RG. Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia. Experimental Neurology 264: 1-7, 2015.
  • Stary CM, Giffard RG. Advances in Astrocyte-targeted Approaches for Stroke Therapy: An Emerging Role for Mitochondria and microRNAS. Neurochemical Research. 40(2):301-7, 2015.
  • Ouyang YB, Giffard RG. MicroRNAs affect BCL-2 family proteins in the setting of cerebral ischemia. Neurochemistry International. 77:2-8, 2014.
  • Ouyang YB, Xu L, Yue S, Liu S, Giffard RG. Neuroprotection by astrocytes in brain ischemia: importance of microRNAs. Neuroscience Letters. 17; 565:53-8, 2014.
  • Sheppard PW, Sun X, Khammash M, Giffard RG. Overexpression of heat shock protein 72 attenuates NF-κB activation using a combination of regulatory mechanisms in microglia. PLoS Computational Biology.  6;10(2):e1003471, 2014.

2011 - 2013 PUBLICATIONS

  • Moon JM, Xu L, Giffard RG. Inhibition of microRNA-181 reduces forebrain ischemia induced neuronal loss. Journal of Cerebral Blood Flow and Metabolism, 33(12): 1976-82, 2013.
  • Ouyang YB, Xu L, Lu Y, Sun XY, Xiong XX, Giffard RG. Astrocyte enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia. Glia, 61(11):1784-1794, 2013.
  • Voloboueva LA, Emery JF, Sun X, Giffard RG. Inflammatory response of microglial BV2 cells includes a glycolytic shift and is modulated by mitochondrial glucose regulated protein 75/mortalin. FEBS Letters, 587(6):756-62, 2013.
  • Xiong X, White RE, Xu L, Yang L, Sun X, Zou B, Pascual C, Sakura T, Giffard RG, Xie X.  Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation. Stroke, 44(3):764-70, 2013.
  • Sun X, Budas G, Xu L, Barreto G, Mochly-Rosen D, Giffard RG. Selective activation of PKC epsilon in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice. J Neurosci Res, 91(6):799-807, 2013.
  • Barreto GE, Sun X, Xu L, White RE, Emery J, Palm CJ, Giffard RG. Effects of Hsp72 on astrocyte activation following stroke in the mouse. Experimental Neurology, 238(2):284-96, 2012.
  • White RE, Palm CJ, Ling EB, Daigle BJ, Han R, Patterson AJ, Altman RB, Giffard RG. Mice lacking the β2 adrenergic receptor have an attenuated inflammatory response to focal cerebral ischemia. ASN Neuro, 4(5):e00096, 2012.
  • Lafargue M, Carles M, Xu L, Iles KE, Tadie-Serve E, Anjum N, Giffard RG, Pittet JF. Stroke increases lung injury caused by pseudomonas aeruginosa via the activation of the α7 nicotinic receptor. FASEB Journal, 26(7):2919-29, 2012.
  • Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, Barres BA. Genomic analysis of reactive astrogliosis. Journal of Neuroscience, 32(18):6391-410, 2012.
  • White RE, Giffard RG. MicroRNA-320 Induces Neurite Outgrowth by Targeting ARPP-1. Neuroreport, 23(10):590-5, 2012.
  • Adelson J, Barreto GE, Xu L, Brott B, Ouyang YB, Naserke T, Djurisic M, Xiong X, Shatz CJ, Giffard RG. Neuroprotection from stroke in the absence of MHCI or PirB. Neuron, 73(6): 1100-7, 2012.
  • Ouyang YB, Lu Y, Yue S, Giffard RG. MiR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes. Mitochondrion, 12: 213-219, 2012.
  • Ouyang YB, Lu Y, Yue S, Xu L, Xiong X, White RE, Sun X, Giffard RG. MiR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo. Neurobiology of Disease 45: 555–563, 2012.
  • Barreto GE, Sun X, Xu L, Giffard RG. Astrocyte proliferation following stroke in the mouse depends on distance from the infarct. PLoS ONE 6(11): e27881, 2011.
  • Voloboueva LA, Giffard RG. Inflammation, mitochondria, and the inhibition of adult neurogenesis. Journal of Neuroscience Research 89: 1989-1996, 2011.
  • Tang XN, Zheng Z, Giffard RG, Yenari MA. Significance of marrow-Derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke. Annals of Neurology 70: 606-615, 2011.
  • Sheppard PW, Sun XY, Emery JF, Giffard RG, Khammash M. Quantitative characterization and analysis of the dynamic NF-kB response in microglia. BMC Bioinformatics, 12: 276, 2011.
  • Kacimi R, Giffard RG, Yenari MA. Endotoxin-activated microglia injure brain derived endothelial cells via NF-kB, JAK-STAT and JNK stress kinase pathways. Journal of Inflammation, 8(7), 2011.
  • Xiong X, Barreto G, Xu L, Ouyang Y, Xie X, Giffard RG. Increased brain injury and worsened neurological outcome in IL-4 Knockout mice following transient focal cerebral ischemia. Stroke, 42: 2026-2032, 2011. Selected and recommended by the Faculty of 1000.
  • Vizcaychipi M, Xu L, Barreto G, Ma D, Maze M, Giffard RG. Heat shock protein 72 overexpression prevents early postoperative cognitive dysfunction following orthopedic surgery under general anesthesia in mice. Anesthesiology, 114(4): 891-900, 2011. Selected as an Editor’s Choice article in Science Translation Medicine.
  • Ouyang YB, Xu L, Emery JF, Lee AS, Giffard RG. Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress. Mitochondrion, 11(2): 279-286, 2011.
  • Xu L, Xiong X, Ouyang YB, Barreto G, Giffard RG. Heat shock protein 72 (Hsp72) improves long-term recovery after focal cerebral ischemia in mice. Neuroscience Letters 488(3): 279-282, 2011.

2009 - 2010 PUBLICATIONS

  • Huang WC, Qiao Y, Xu L, Kacimi R, Sun X, Giffard RG, Yenari MA. Direct protection of cultured neurons form ischemia-like injury by minocycline. Anatomy and Cell Biology, 43(4): 325-331, 2010.
  • Voloboueva LA, Lee SW, Emery JF, Palmer TD, Giffard RG. Mitochondrial Protection Attenuates Inflammation-Induced Impairment of Neurogenesis. In Vitro and In Vivo. Journal of Neuroscience: 30:12242-51, 2010, PMID 20844120.
  • Loram LC, Harrison JA, Chao L, Taylor FR, Reddy A, Travis CL, Giffard R, Al-Abed Y, Tracey K, Maier SF, Watkins LR. Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats. Brain, Behavior, and Immunity 24:959-67, 2010. PMID20353818.
  • Xu L, Emery JF, Ouyang YB, Voloboueva LA, Giffard RG. Astrocyte targeted overexpression of Hsp72 and SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia, 58:1042-9, 2010. PMID 20235222.
  • Barreto G, Huang TT, Giffard RG. Age-related defects in sensorimotor activity, spatial learning, and memory in C57BL/6 mice. Journal of Neurosurgical Anesthesiology: 22(3); 214-19, 2010. PMID 20479674.
  • Xu L, Voloboueva LA, Ouyang Y, Emery JF, Giffard RG. Overexpression of mitochondrial Hsp70/75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia. Journal of Cerebral Blood Flow Metabolism, 29(2); 365-74, 2009. PMID 18985056