George Lab Research

Conductive polymers scaffolds for stem cell-enhanced stroke recovery

We focus on developing conductive polymers for stem cell applications.  We have created a microfabricated, polymeric system that can continuously interact with its biological environment.  This interactive polymer platform allows modifications of the recovery environment to determine essential repair mechanisms. Recent work studies the effect of electrical stimulation on neural stem cells seeded on the conductive scaffold and the pathways by which it enhances stroke recovery  Further understanding the combined effect of electrical stimulation and stem cells in augmenting neural repair for clinical translational is a major focus of this research going forward.

Biopolymer systems for neural recovery and understanding stroke repair pathways

The George lab develops biomaterials to improve neural recovery in the peripheral and central nervous systems. By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. By identifying the critical mechanisms for stroke and neural recovery, we are able to develop polymeric technologies for clinical translation in nerve regeneration and stroke recovery.

Applying engineering techniques to determine biomarkers for stroke diagnostics

The ability to create diagnostic assays and techniques enables us to understand biological systems more completely and improve clinical management. Previous work utilized mass spectroscopy proteomics to find a simple serum biomarker for TIAs (a warning sign of stroke). Our study discovered a novel candidate marker, platelet basic protein. Current studies are underway to identify further candidate biomarkers using transcriptome analysis.  More accurate diagnosis will allow for aggressive therapies to prevent subsequent strokes.

Clinical Trials

Imaging Collaterals in Acute Stroke (iCAS), Recruiting