Our lab studies the role of organelles and subcellular metabolism in health and disease using genetic screens as well as state-of-the-art metabolomics and proteomics.
The Helix Group at Stanford is directed by Russ Altman.
Associate Dean, School of Medicine, Roger and Joelle Burnell Professor of Genomics and Precision Health, Professor of Medicine (Cardiovascular Medicine), of Genetics, of Biomedical Data Science and, by courtesy, of Pathology
The Ashley lab is focused on the application of genomics to medicine.
The p53 transcription factor provides a potent barrier to cancer development, yet its inappropriate activation can cause detrimental phenotypes. In our lab, we strive to deconvolute the cellular and molecular programs through which p53 promotes beneficial and deleterious effects, key knowledge for ultimately modulating this protein for improving human health.
Cellular differentiation is governed by dynamic changes occurring in the genome.
“We study post-transcriptional regulation of gene expression. We are interested in all facets of RNA biology from decoding the genome to function in cells and tissues.”
We develop and use high-complexity shRNA and CRISPR/Cas9-based tools to study stress signaling, endocytosis, and the biology of novel drugs.
The Bhatt lab applies modern genetic tools to deconvolute how the microbiome is intertwined with states of health and disease.
Michele and Timothy Barakett Endowed Professor
Dr. Brunet is interested in the molecular mechanisms of aging and longevity, with a particular emphasis on the nervous system. Her lab is interested in identifying pathways involved in delaying aging in response to external stimuli such as availability of nutrients and mates. She also seeks to understand the mechanisms that influence the rejuvenation of old stem cells. Finally, her lab has pioneered the naturally short-lived African killifish as a new model to explore the regulation of aging and age-related diseases.
Our laboratory studies the molecular mechanisms of aging and longevity.
The Calos Lab is interested in developing novel gene and cell therapy approaches to address human diseases.
MS Program in Human Genetics and Genetic Counseling:
The Stanford MS Program in Human Genetics and Genetic Counseling began in 2008 and is fully accredited by the Accreditation Council for Genetic Counseling (ACGC).
The Chang lab is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning..
Innovation in literature curation, dataset validation and ontologies enhance experimental results.
We study RNA decay, microbial antibiotic resistance, and mechanisms that regulate transcription elongation through genes containing expanded regions of trinucleotide repeats.
Cong Lab is developing scalable CRISPR and single-cell genomics technology with computational/data analysis to understand cancer immunology and neuro-immunology.
We aim to characterize the evolutionary dynamics of tumor progression and the genotype-phenotype map in cancer by leveraging both experimental and computational approaches.
Our center develops new technologies to address important biological questions that otherwise would not be feasible.
Assistant Professor of Genetics
Jesse is currently an Assistant Professor at Stanford University in the Department of Genetics and the Children’s Heart Center Basic Sciences and Engineering (BASE) Initiative, and is a recipient of the NHGRI Genomic Innovator Award. He co-leads a Functional Characterization Center at Stanford for the Impact of Genomic Variation on Function (IGVF) Consortium, and is an Associate Director of the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute. Previously, Jesse was a Junior Fellow at the Harvard Society of Fellows and led a research group at the Broad Institute of MIT and Harvard. During his postdoctoral fellowship at the Broad Institute, Jesse developed large-scale CRISPR tools to map enhancer-gene regulation with Eric Lander and Nir Hacohen, and launched the Variants-to-Function (V2F) Initiative to connect genetic disease variants to their molecular and cellular functions. Jesse previously attended Stanford University, where he developed computational algorithms for analyzing gene expression with Russ Altman, and completed his PhD in the Harvard-MIT Division of Health Sciences and Technology, where he studied genome regulation by long noncoding RNAs with Eric Lander and Mitch Guttman. His research has been supported by the National Human Genome Research Institute, National Heart, Lung, and Blood Institute, Additional Ventures, Foundations for the National Institutes of Health, Harvard Society of Fellows, Fannie and John Hertz Foundation, and Department of Defense. Outside the lab, Jesse enjoys playing jazz/rock/funk, testing Chinese recipes, and surfing.