Gene Therapy Clinical Trials
Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Detecting Lactate and Bicarbonate in Participants With Central Nervous System Tumors
This early phase I trial studies how well hyperpolarized carbon C 13 pyruvate magnetic resonance imaging works in detecting lactate and bicarbonate in participants with central nervous system tumors. Hyperpolarized carbon C 13 pyruvate magnetic resonance imaging may be used to measure the metabolic state of malignant brain tumors.
Stanford is currently not accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- other: Gadolinium
- drug: Hyperpolarized Carbon C 13 Pyruvate
- procedure: Magnetic Resonance Imaging
- procedure: Magnetic Resonance Spectroscopic Imaging
Eligibility
Inclusion Criteria:
- Patients with a known diagnosis of central nervous system (CNS) malignancy, including
metastases, with known enhancement on magnetic resonance (MR) who are otherwise
eligible to undergo MRI
- Glomerular filtration rate (GFR) > 30 ml/min
- No allergy to gadolinium
- Ability to understand and the willingness to sign a written informed consent document
Exclusion Criteria:
- Refusal to have an IV placed for injection
- Acute major illness (e.g., unstable angina, etc.) or other condition that makes
participation unsafe, per the investigator?s judgement
- Total bilirubin > 1.5 x upper limit of normal (ULN)
- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 2.5 x ULN
- Gamma-glutamyltransferase (GGT) > 2.5 x ULN
- Pregnant or breast-feeding
- Cardiovascular risk, including:
- Poorly controlled hypertension, defined as either systolic > 170 or diastolic >
110
- Congestive heart failure
- Myocardial infarction within the past year
- QT prolongation, defined as pretreatment corrected QT interval (QTc) > 440 msec
in males or > 460 msec in females
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Not currently accepting new patients for this trial
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Lewis Naya
650-725-0739
Not Recruiting