Clinical Trials
OVERVIEW
The Division of Gastroenterology and Hepatology conducts clinical trials on novel therapeutics for various liver diseases, bringing promising and innovative therapies to our patients.
Our team has extensive experience selecting the right patients for the right trials.
Clinical trials are an important part of the research involved in developing new medical treatments. Enrolling in a clinical trial enables participants to take an active role in their own health care, gain entrance to new research, and contribute to medical science.
Participants must meet specific criteria to be eligible for enrollment in a clinical trial. Some research studies seek participants with illnesses or specific conditions to be studied in the clinicaltrial, while others ask for healthy participants.
CURRENT AND ONGOING TRIALS
Vitamin D Regulation of Gut Specific B Cells and Antibodies Targeting Gut Bacteria in Inflammatory Bowel Disease
Specific Aim 1: Characterize the effects of vitamin D treatment on expression of α4β7 on B cells in patients with inflammatory bowel disease (IBD).
Specific Aim 2: Determine the effects of vitamin D treatment on fecal immunoglobulins, percentage of Ig-coated gut bacteria, gut microbiome composition (global and bound by immunoglobulins) in patients with IBD and the association of these parameters with change in α4β7+ B cells .
Specific Aim 3: Compare BCR repertoire (BCR clonotypes, immunoglobulin heavy chain gene (IGHV), and isotype usage) between α4β7+ and α4β7- B cells in patients with IBD and identify α4β7+ BCR clonotypes associated with Ig-bound gut bacteria .
Stanford is currently not accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- drug: Vitamin D
Eligibility
Inclusion Criteria:
- Adult patients (18 years or older) with inflammatory bowel disease (ulcerative colitis
or Crohn's disease)
- Low serum vitamin D (25(OH)D ≤ 25 ng/mL
- Not currently on high dose vitamin D supplementation
- No prior bowel resections
- No antibiotic use in past 3 months.
Exclusion Criteria:
- Patients less than 18 years old
- No diagnosis of IBD
- Serum 25(OH)D > 25 ng/mL
- Patients already on vitamin D supplementation
- Prior history of bowel surgery (colectomy or small bowel resections)
- Recent antibiotic use in past 3 months
- Renal Dysfunction
- History of Hypercalcemia
- History of HIV
- History of IgA deficiency
- History of Common Variable Immunodeficiency (CVID)
- Active C. diff infection
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Not currently accepting new patients for this trial
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
John Gubatan, MD
650-725-3362
Not Recruiting