Publications

  • Wang JL, Le Gall J, Frock RL, Strick TR. 2023. Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation. Nature Structural & Molecular Biology Oct 12 PMCID: pending bioRxiv preprint: Nov. 2022
  • Barghouth PB, Melemenidis S, Montay-Gruel P, Ollivier J, Viswanathan V, Jorge PG, Soto LA, Lau BC, Sadeghi C, Edlabadkar A, Zhang R, Ru N, Baulch JE, Manjappa R, Wang J, Le Bouteiller M, Surucu M, Yu A, Bush K, Skinner L, Maxim PG, Loo Jr BW, Limoli CL, Vozenin M-C, Frock RL. 2023. FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates. Radiotherapy and Oncology. Sep 9:188:109906.
  • Frock RL, Sadeghi C, Meng J, Wang JL. DNA End Joining: G0-ing to the Core. Biomolecules. 2021 Oct 9;11(10):1487. doi: 10.3390/biom11101487. PMID: 34680120
  • Lattanzi A, Camarena J, Lahiri P, Segal H, Srifa W, Vakulskas CA, Frock RL, Kenrick J, Lee C, Talbott N, Skowronski J, Cromer MK, Charlesworth CT, Bak RO, Mantri S, Bao G, DiGiusto D, Tisdale J, Wright JF, Bhatia N, Roncarolo MG, Dever DP, Porteus MH. Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease. Sci Transl Med. 2021 Jun 16;13(598):eabf2444. doi: 10.1126/scitranslmed.abf2444. PMID: 34135108
  • Liang Z, Kumar V, Le Bouteiller M, Zurita J, Kenrick J, Lin SG, Lou J, Hu J, Ye AY, Boboila C, Frock RL 2021 Ku70 suppresses alternative end-joining in G1-arrested progenitor B cells. Proc. Natl. Acad. Sci. USA. 118 (21) e2103630118; DOI: 10.1073/pnas.2103630118PMID:34135108
  • Wang Q, Liu J, Janssen JM, Le Bouteiller M, *Frock RL, Gonçalves MAFV. 2021. Precise and broad scope genome editing based on high-specificity Cas9 nickases.  Nucleic Acids Research. Jan4;gkaa1236. DOI10.1093/nar/gkaa1236 PMID:33398349
  • Chen X, Tasca F, Wang Q, Liu J, Janssen JM, Brescia MD, Bellin M, Szuhai K, Kenrick J, Frock RL, Gonçalves MAFV. 2020.  Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking.  Nucleic Acids Research. Jan 24;48(2):974-995. DOI: 10.1093/nar/gkz1121. PMID:31799604
  • Layer JV, Cleary JP, Brown AJ, Stevenson KE, Morrow SN, Van Scoyk A, Blasco RB, Karaca E, Meng FL, Frock RL, Tivey T, Kim S, Fuchs H, Chiarle R, Alt FW, Roberts SA, Weinstock DM, Day TA. 2018. Parp3 promotes long-range end joining in murine cells.  Proc Natl Acad Sci U S A. 115(40):10076-10081. PMCID:PMC6176633.
  • Willis NA, Frock RL, Menghi F, Duffey EE, Panday A, Camacho V, Hasty EP, Liu ET, Alt FW, Scully R. 2017. Mechanism of tandem duplication formation in BRCA1-mutant cells. Nature. 551(7682):590-595. PMCID: PMC5728692.
  • Paulsen BS, Mandal PK, Frock RL, Boyraz B, Yadav R, Gutierrez-Martinez P, Ebina W, Fasth A, Talkowski ME, Agarwal S, Alt FW, Rossi DJ. 2017. Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR/Cas9-mediated genome editing. Nature Biomedical Engineering. 1, 878-888. DOI: 10.1038/s41551-017-0145-2.
  • *Kumar V, Alt FW, *Frock RL2016. PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line. Proc Natl Acad Sci USA. 113(38):10619-24. PMCID: PMC5035843.
  • *Zhao L, *Frock RL, Du Z, Hu J, Chen L, Krangel MS, Alt FW. 2016. Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. Journal of Experimental Medicine. 213(9):1921-1936. PMCID: PMC4995090.
  • Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL2016. Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nature Protocols. 11(5):853-71. PMCID: PMC4895203.
  • Hu J, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng FL Schatz DG, Alt FW. 2015. Chromosomal loop domains direct the recombination of antigen receptors genes. Cell. 163(4):947-59. PMCID: PMC4660266.
  • *Frock RL, *Hu J, Meyers RM, Ho YJ, Kii E, Alt FW. 2015. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nature Biotechnology. 33(2):179-86. PMCID:PMC4320661.
  • *Chiarle R, *Zhang Y, *Frock RL, *Lewis SM, Molinie B, Ho YJ, Myers DR, Choi VW, Compagno M, Malkin DJ, Neuberg D, Monti S, Giallourakis CC, Gostissa M, Alt FW. 2011. Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells. Cell. 147(1):107-19. PMCID: PMC3186939.

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