Mechanisms of DNA double-stranded break repair and Chromosomal Translocation

The Frock Lab studies the genome-wide fate of various forms of double-stranded DNA breaks (DSBs). Projects in the lab use a combination of genetics, molecular biology, next generation sequencing, and bioinformatics to uncover DSB mechanisms and to reveal a deeper understanding of DSB repair processes.

The long term goal of the Frock lab is to develop novel cancer diagnostics/therapeutics and genome editing approaches.

Please visit for more information.

Latest News in the Frock Lab

Check out the latest work from the lab on bioRxiv describing how the DNA Damage Response works with alternative end joining to suppress microhomology-mediated end joining! -- April 2024

Congratulations to Jinglong for his publication on DNA-PK kinase inhibition and impact to chromosome translocations in Nucleic Acids Research! -- February 2024

Welcome to Carrie Truong working on a remote project from St. Joseph Notre Dame! -- November 2023

Congratulations to Jinglong for his published paper on Cas9 cleavage plasticity in the Nature Structural & Molecular Biology! -- October 2023

Welcome, Elvis Lang, to the lab this summer coming from from Case Western Reserve! -- June 2023

Check out the first episode of Science in 5 by Kai Zheng on youtube! -- June 2023

Welcome to Darsh Vithlani working on a remote summer project with us from the Institute of Chemical Technology in Mumbai, India! -- May 2023

Congratulations to Richard Frock who received a Research Scholar Grant from the American Cancer Society (ACS) -- April 2023

Check out Paul’s manuscript on FLASH radiotherapy, hypoxia, apoptosis, and chromosome translocations! -- March 2023

Excellent presentation by Jinglong for his Stanford Cancer Institute talk! -- February 2023

Science in 5 or Sci-5 collaboration with Kai Zheng is in the works…stay tuned! -- January 2023

Great work by Jinglong and colleagues for putting together an excellent manuscript! -- November 2022

Welcome, Anushka Edlabadkar, to the Frock lab!  The third time’s a charm! -- July 2022

Welcome, Long Le and Kristin Conner, to the Frock lab! -- June 2022

Congrats to Jinglong for getting accepted into the GSB Ignite program! -- May 2022

Great job, Jinglong, on your SCI seminar presentation! -- March 2022

Congratulations to Cheyenne for getting accepted in to the BIO-X summer program! Great way to start off the meiosis collaboration. -- February 2022

Congrats to current and alum lab members for helping with the DNA end joining review now published in Biomolecules. -- October 2021

Welcome to Anita Taft, Cheyenne Ali Sadeghi and Jodie Meng, Undergraduate Interns to the Frock Lab -- July 2021

Our part in a great collaborative genome therapy study for Sickle Cell Disease led by the Porteus group is now out in Science Translational Medicine. -- June 2021

Our JoinT-seq paper was highlighted with a Q & A as a publication of the week by Stem Cell Technologies! -- June 2021

Congratulations to Paul for nabbing a position at Nucleix!  We can’t wait to see what comes next. -- June 2021

Just in Time!  Our manuscript describing JoinT-seq was published in the Proceedings of the National Academy of Sciences.  Congrats to Marie and Josefin for developing such a useful tool. -- May 2021

A proud farewell to Marie!  An integral lab member, we wish her all the best in Europe. -- May 2021

Great talk by Jinglong for the Stanford Cancer Institute Radiation Biology Seminar! -- April 2021

Brilliant team effort! Our long-awaited DSB repair study in G0/G1-phase is out on bioRxiv. -- February 2021

The long and the short of it - farewell to Josefin and Carlos. Exciting opportunities lie ahead for you both! -- February 2021

Well done, Marie! Collaborative paper led by the Gonçalves group is published in Nucleic Acids Research. -- January 2021

Frock Lab virtual reunion! -- September 2020

Welcome Carlos Origel, Postdoctoral Scholar to the Frock Lab -- March 2020

Welcome Jinglong Wang, Postdoctoral Scholar to the Frock Lab -- January 2020

Congratulations to Dr. Frock for becoming a V Scholar from the V Foundation for Cancer Research! -- November 2019

Way to go, Paul, for presenting at the Department Retreat at SLAC and then giving a different talk for the Division Floor Meeting the following week! -- October 2019

Welcome Marie Le Bouteiller, Postdoctoral Scholar to the Frock Lab -- September 2019

Finn’s summer internship is over but we hope to see him again in the near future! We can’t wait to see what he’ll do next! -- August 2019

Welcome Paul Barghouth, Postdoctoral Scholar to the Frock Lab -- June 2019

Grateful for the support in the lab’s first phase, Melissa Wong! Excited to have Meg Fuentes support the next phase of the lab. -- June 2019

Welcome Finn Maniscalco, Summer Intern to the Frock Lab -- June 2019 to August 2019

Micah gave an excellent Floor Meeting presentation! -- May 2019

Congratulations to Dr. Frock for receiving the Career Development Award from the Radiation Research Foundation! -- April 2019

Josefin gave an awesome presentation for the Division Floor Meeting! -- February 2019

Woot! Collaborative paper led by the Weinstock group is published in the Proceedings of the National Academy of Sciences. -- August 2018

Welcome, Josefin Kenrick, to the Frock lab! -- July 2018

Welcome, Micah Kelly, to the Frock lab! -- March 2018

Dr. Frock was mentioned in The Scientist: New Methods to Detect CRISPR Off-Target Mutations! -- March 2018

Dr. Frock was mentioned in a Biotechniques article: CRISPR/Cas9 eliminates chromosomes. -- January 2018