Functional Genomics of DSB Repair Processes
The Frock Lab studies the genome-wide fate of various forms of double-stranded DNA breaks (DSBs). Projects in the lab use a combination of genetics, molecular biology, next generation sequencing, and bioinformatics to uncover DSB mechanisms and to reveal a deeper understanding of DSB repair processes.
The long term goal of the Frock lab is to develop novel cancer diagnostics/therapeutics and genome editing approaches.
Visit frocklab.com for more information
There are a variety of DNA double strand break (DSB) sources. The DNA Damage Response is a reversible epigenetic process that synergizes repair efficiency by supporting engaged repair pathways. Importantly, emerging secondary repair pathways, fine mechanistic detail of primary repair, and the contexts to which they are all used remain to be fully elucidated. We seek to understand the genome-wide DSB repair fates and how they can be leveraged into effective therapies.
Our functional genomics projects cover many different fields: radiation and cancer biology, genome editing, immunology, and cell cycle phase-restricted DSB repair.
Latest News in the Frock Lab
Farewell to Cheyenne who was dedicated to do research for the long haul in the lab. We have great expectations for you @ UNC! -- June 2025
Grateful to have contributed to the work from our neighbors, the Rankin lab. Pub is out now @ JCI Insight! -- June 2025
Welcome, Olivia Santos, to the Frock Lab! -- June 2025
Welcome, Faiza Chowdhury, to the Frock Lab! -- May 2025
Congratulations to Carrie for deciding to attend Harvard University in the fall! They are fortunate to have your talents! -- April 2025
Congratulations to Cheyenne for accepting the offer to join the UNC MD PhD program! Threaded the needle just before the window closed. -- April 2025
Welcome Garima Chaturvedi, PhD to the Frock lab! -- March 2025
Perfect timing! 3 papers published in 2 weeks (Genes and Development and Nature Communications) thanks to great collaborators. The final one a publication for Jinglong’s deep dive into alternative end joining and DDR collaboration in quiescent cells out in Science Advances!
Check out the latest work from the lab on bioRxiv describing how the DNA Damage Response works with alternative end joining to suppress microhomology-mediated end joining! -- April 2024
Congratulations to Jinglong for his publication on DNA-PK kinase inhibition and impact to chromosome translocations in Nucleic Acids Research! -- February 2024
... and more!
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