BFAM Member Spotlights

Meet the members of the Stanford Medicine Black Faculty Affinity Meetings (BFAM), a network created through OFDD's Community Support Initiative. BFAM is intended to provide networking and social engagement opportunities for Stanford Medicine faculty across all clinical lines and departments.

Iris C. Gibbs, MD, FAAWR, FACR, FASTRO

Radiation Oncology

Associate Dean of MD Admissions Chair
Diversity Sub-committee of the SOM Faculty Senate

Research Interests
Cyberknife radiosurgery, spinal radiosurgery, pediatric brain tumors, adult brain tumors, health equity

Something you wouldn’t know just by looking at me.
During the COVID-19 pandemic I revived my love of singing and writing. I am the only member of my book club who does not currently live in Los Angeles--shout out to Literary Sisters West!!

Full Stanford Profile

Professor of Radiation Oncology (Radiation Therapy) and, by courtesy, of Neurosurgery

(650) 736-1480

iris.gibbs@stanford.edu

Publications

A Case-based Guide for World Health Organization (WHO) Grade 2 Meningioma Radiosurgery and Radiation Therapy from The Radiosurgery Society. Practical radiation oncology Vassantachart, A. K., Ehret, F., Chen, E., Kumar, R., Gogineni, E., Andraos, T. Y., Sahgal, A., Redmond, K. J., Lo, S. S., Chang, E. L., Sheehan, J., Chao, S. T., Kim, G. G., Kresl, J. J., Schulder, M., Palmer, J. D., Gibbs, I. C., Santacroce, A., Shih, H. A. 2024 More

Abstract

PURPOSE: Meningiomas represent the most common primary tumor of the central nervous system. Current treatment options include surgical resection with or without adjuvant radiation therapy (RT), definitive RT, and observation. However, the radiation dose, fractionation, and margins used to treat patients with WHO grade 2 meningiomas, which account for approximately 20% of all meningiomas, are not clearly defined, and deciding on the optimal treatment modality can be challenging owing to the lack of randomized data.METHODS AND MATERIALS: In this manuscript, 3 cases of patients with WHO grade 2 meningiomas are presented with descriptions of treatment options after gross total resection, subtotal resection, and recurrent tumors within a prior irradiated field. Treatment recommendations were compiled from 9 central nervous system radiation oncology and neurosurgery experts from The Radiosurgery Society, and the majority consensus of treatment guidelines are reported.RESULTS: Both conventional and stereotactic RT are treatment options for WHO grade 2 meningiomas. The majority of prospective data in the setting of WHO grade 2 meningiomas involve larger margins. Stereotactic radiosurgery/hypofractionated stereotactic RT are less appropriate in this setting. Conventionally fractionated RT to at least 59.4 Gy is considered standard of care with utilization of preoperative and postoperative imaging to evaluate the extent of disease and possible osseous involvement. After careful discussion, stereotactic radiosurgery/hypofractionated stereotactic RT may play a role for the subset of patients who are unable to tolerate the standard lengthy conventionally fractionated treatment course, for those with prior RT, or for small residual tumors. However, more studies are needed to determine the optimal approach.CONCLUSIONS: This case-based evaluation of the current literature seeks to provide examples for the management of grade 2 meningiomas and give examples of both conventional and stereotactic RT.

View details for DOI 10.1016/j.prro.2024.02.009

View details for PubMedID 38970567
How Ending Affirmative Action May Affect Radiation Oncology Workforce and Our Patients: A Collaboration of the American Society of Radiation Oncology, Society of Chairs of Academic Radiation Oncology Programs, Association for Directors of Radiation Oncology Programs, and Association of Residents in Radiation Oncology. International journal of radiation oncology, biology, physics LeCompte, M. C., Gibbs, I. C., Taparra, K., Suneja, G., Jr, C. D., Ii, Z. W., MacDuffie, E., Pinnix, C. C., Kamrava, M., Jimenez, R. B., Currey, A. D., Chen, Y., Franco, I. 2024 More

View details for DOI 10.1016/j.ijrobp.2024.06.014

View details for PubMedID 38944312
CyberKnife stereotactic radiosurgery for extramedullary plasmacytoma in the external auditory canal: illustrative case. Journal of neurosurgery. Case lessons Patil, S., Shaghaghian, E., Yuan, L., Shah, A., Marianayagam, N. J., Park, D. J., Soltys, S. G., Veeravagu, A., Gibbs, I. C., Li, G., Chang, S. D. 2024; 7 (19) More

Abstract

Plasmacytoma, a rare plasma cell disorder, often presents as a solitary or multiple tumors within the bone marrow or soft tissues, typically associated with multiple myeloma. Extramedullary plasmacytomas (EMPs), particularly those located in the external auditory canal (EAC), are exceedingly rare and pose significant treatment challenges given their location, anatomical complexity, and high risk of recurrence.The authors report the case of a 72-year-old male with a history of multiple myeloma, presenting with recurrent left EAC plasmacytoma. After initial conventional radiotherapy for the lesion, a recurrence was documented in 7 years. The patient subsequently underwent stereotactic radiosurgery, which proved successful, leading to complete resolution of the lesion without any long-term adverse effects or radiation-related complications over a 45-month period.This case is a unique instance of utilizing stereotactic radiosurgery for recurrent EMP in the EAC, highlighting its potential as an effective approach in managing complex plasmacytomas.

View details for DOI 10.3171/CASE2479

View details for PubMedID 38710109

View details for PubMedCentralID PMC11076403
Automated contouring, treatment planning, and quality assurance for VMAT craniospinal irradiation (VMAT-CSI). Frontiers in oncology Simiele, E., Romero, I. O., Wang, J. Y., Chen, Y., Lozko, Y., Severyn, Y., Skinner, L., Yang, Y., Xing, L., Gibbs, I., Hiniker, S. M., Kovalchuk, N. 2024; 14: 1378449 More

Abstract

Create a comprehensive automated solution for pediatric and adult VMAT-CSI including contouring, planning, and plan check to reduce planning time and improve plan quality.Seventy-seven previously treated CSI patients (age, 2-67 years) were used for creation of an auto-contouring model to segment 25 organs at risk (OARs). The auto-contoured OARs were evaluated using the Dice Similarity Coefficient (DSC), 95% Hausdorff Distance (HD95), and a qualitative ranking by one physician and one physicist (scale: 1-acceptable, 2-minor edits, 3-major edits). The auto-planning script was developed using the Varian Eclipse Scripting API and tested with 20 patients previously treated with either low-dose VMAT-CSI (12 Gy) or high-dose VMAT-CSI (36 Gy + 18 Gy boost). Clinically relevant metrics, planning time, and blinded physician review were used to evaluate significance of differences between the auto and manual plans. Finally, the plan preparation for treatment and plan check processes were automated to improve efficiency and safety of VMAT-CSI.The auto-contours achieved an average DSC of 0.71 ± 0.15, HD95 of 4.81 ± 4.68, and reviewers' ranking of 1.22 ± 0.39, indicating close to "acceptable-as-is" contours. Compared to the manual CSI plans, the auto-plans for both dose regimens achieved statistically significant reductions in body V50% and Dmean for parotids, submandibular, and thyroid glands. The variance in the dosimetric parameters decreased for the auto-plans as compared to the manual plans indicating better plan consistency. From the blinded review, the auto-plans were marked as equivalent or superior to the manual-plans 88.3% of the time. The required time for the auto-contouring and planning was consistently between 1-2 hours compared to an estimated 5-6 hours for manual contouring and planning.Reductions in contouring and planning time without sacrificing plan quality were obtained using the developed auto-planning process. The auto-planning scripts and documentation will be made freely available to other institutions and clinics.

View details for DOI 10.3389/fonc.2024.1378449

View details for PubMedID 38660134

View details for PubMedCentralID PMC11039907
Stereotactic Radiosurgery in the Management of Brain Metastases: A Case-Based Radiosurgery Society Practice Guideline. Advances in radiation oncology Ladbury, C., Pennock, M., Yilmaz, T., Ankrah, N. K., Andraos, T., Gogineni, E., Kim, G. G., Gibbs, I., Shih, H. A., Hattangadi-Gluth, J., Chao, S. T., Pannullo, S. C., Slotman, B., Redmond, K. J., Lo, S. S., Schulder, M. 2024; 9 (3): 101402 More

Abstract

Brain metastases are common among adult patients with solid malignancies and are increasingly being treated with stereotactic radiosurgery (SRS). As more patients with brain metastases are becoming eligible for SRS, there is a need for practical review of patient selection and treatment considerations.Two patient cases were identified to use as the foundation for a discussion of a wide and representative range of management principles: (A) SRS alone for 5 to 15 lesions and (B) a large single metastasis to be treated with pre- or postoperative SRS. Patient selection, fractionation, prescription dose, treatment technique, and dose constraints are discussed. Literature relevant to these cases is summarized to provide a framework for treatment of similar patients.Treatment of brain metastases with SRS requires many considerations including optimal patient selection, fractionation selection, and plan optimization.Case-based practice guidelines developed by the Radiosurgery Society provide a practical guide to the common scenarios noted above affecting patients with metastatic brain tumors.

View details for DOI 10.1016/j.adro.2023.101402

View details for PubMedID 38292892

View details for PubMedCentralID PMC10823095

see all 178 publications

BFAM Member Spotlights

Iris C. Gibbs, MD, FAAWR, FACR, FASTRO

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