The Eye-Brain Lab focuses on the understanding and treatment of human conditions that lead to vision loss and degeneration of the eye-brain connections. We use animal models of anterior ischemic optic neuropathy, the most common acute optic neuropathy in adults, hypoxia, and others. We also perform studies of the human eye-brain network by using advanced optical, vascular, and brain imaging techniques to measure changes in the structure of the eye and the brain due to various neuro-ophthalmic diseases.

Current research areas for optic neuropathies include:
1) Study of the cellular and subcellular changes to the retinal neurons, glia, axons in optic neuropathies and diabetes;

2) Development of highly promising treatment approaches for optic neuropathies and vision loss, including neuroprotection and regenerative therapy, in order to identify effective ways to treat human vision loss in the future;

3) Development of state-of-the-art in vivo optical eye and brain imaging in humans and animal models of hypoxic-ischemic injury, in order to identify novel biomarkers that can help direct treatment and to facilitate bench-to-bedside translation of research findings.

Y. Joyce Liao, MD, PhD