Edgar G. Engleman, MD

Professor of Pathology and of Medicine (Immunology and Rheumatology)
Medical Director, Stanford Blood Center
Co-Director, Tumor Immunology and Immunotherapy, Stanford Cancer Institute
Member, Stanford Diabetes Research Center, Stanford

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Email: edengleman@stanford.edu

Sreya Bagchi, PhD 

Postdoctoral Fellow in Pathology
Field of research/study: Tumor immunology and autoimmunity 

I am interested in learning how obesity alters the immune landscape, for example, how and why it increases both the frequency and severity of certain cancers. We have made some exciting discoveries that appears to offer a mechanistic explanation. Hopefully, this work will lead to new therapies for these patients.

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Email: sbagchi@tanford.edu

Pamela Basto, MD, PhD

Hematology/Oncology Fellow 

I am a physician scientist, specializing in medical oncology with a focus in the discovery of novel anti-tumor immune mechanisms and engineering cellular therapies against metastatic solid cancers with a particular interest in gastrointestinal malignancies. I hope to translate new discoveries found in the laboratory in order to help all patients with cancer have longer and better lives.

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Email: basto@stanford.edu

David Kung-Chun Chiu, PhD

Postdoctoral Fellow in Pathology 

I studied the genetics of liver cancer during my graduate training in Hong Kong. Here at Stanford, I am using different genome editing tools and mouse models to investigate the role of macrophages in promoting tumor progression and immune tolerance in liver cancer. Our findings indicate that tumor associated macrophages including Kupfer cells, have a profound impact on liver cancer and I am studying the molecular basis for these effects.

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Email: kcchiu@stanford.edu

Han-Li Huang, PhD

I am a visiting scholar from Taiwan Medical University. My interests focus on cancer immunology and anti-cancer drug discovery, and I am currently working on deciphering epigenetic mechanisms of lymph node metastasis and novel myeloid target validation.

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Email: hanlih@stanford.edu

Kazukuni Hayashi, PhD

Postdoctoral Fellow in Pathology

I am interested in understanding the tumor-immune mechanisms responsible for tumor-specific immune tolerance with the goal of developing therapies to overcome this pathobiological process. My current focus is on identifying the types, locations and factors that regulate the antigen presenting cells responsible for inducing Tregs in cancer and other settings. Aside from science, I enjoy playing soccer and tennis, as well as going on a food/boba run.

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Email: hayashik@stanford.edu

Sameera Kongara, PhD

Postdoctoral Fellow in Pathology 

I’m interested in understanding how myeloid cells influence the development of tumors, and in examining ways in which their behavior can be modulated to improve therapeutic outcomes. Currently, my work focuses on a novel receptor expressed by myeloid cells in several types of cancers, including pancreatic ductal adenocarcinoma, which can be targeted to induce anti-tumor immunity.

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Email: skongara@stanford.edu

Ian Linde, PhD

Former graduate student and current postdoctoral fellow

My work led to the discovery that neutrophils can be activated to attack and eradicate tumors in mice. I continue to work on this new immunotherapy approach, identifying the molecules that activate neutrophils in bone marrow and attract them to tumors, as well as the molecules produced by the activated neutrophils that result in tumor cell death. 

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Email: ilinde@stanford.edu

Madonna Meneses

Lab Assistant 1

I am passionate and I love what I do in my job, which includes a variety of laboratory support functions, ranging from preparation of critical reagents to assistance with mouse experiments. Outside work, I am a dedicated mother, a wife and very family-oriented person.

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Email: menesesm@stanford.edu

Alexander Muselman

PhD candidate, Immunology program

I completed my undergraduate degree at UC San Diego, where I studied how dysregulation of myelopoiesis leads to acute myeloid leukemia.  Then, I worked as a research technician at the University of Pennsylvania studying the role of circulating T follicular helper cells in response to influenza vaccination.  As a graduate student, I am now examining the role of myeloid cells in driving neuroinflammation in the context of brain tumors, CNS autoimmunity, and neurodegenerative disorders.

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Email: amuselma@stanford.edu

Nathan E. Reticker-Flynn, PhD

Instructor, Department of Pathology 

I am a Biomedical Engineer and tumor immunologist working at the interfaces of cancer metastasis, tumor evolution, adaptive immunity, and immuno-oncology. As a postdoctoral scholar in the Engleman Lab, I focused on using systems approaches and mouse models to investigate tumor-immune interactions during metastasis and responses to immunotherapies. My discoveries include the revelation that effective immunotherapies require systemic activation of anti-tumor immunity (Spitzer*, Carmi*, Reticker-Flynn*, Cell, 2017) and that lymph node metastases serve to reeducate adaptive immune responses in a manner that promotes distant metastasis (Reticker-Flynn, Cell, 2022). I will be opening my own laboratory in the Stanford Department of Otolaryngology–Head and Neck Surgery in the fall/winter of 2022.

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Email: retickerflynn@stanford.edu

Yoni Rubin, PhD 

Stanford Medical Student 

My research combines computational and cellular immunology to study auto-inflammatory conditions. Currently, I focus on novel diagnostics and therapeutics for inflammatory bowel diseases.

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Email: yrubin@stanford.edu

Xiangyue Zhang, PhD

Research Scientist

My long-term passion for immunology research is to understand how antigen-specific tolerance is formed from the perspectives of both antigen-presenting cells (APCs), e.g., dendritic cells and macrophages, and T cells including both antigen-specific CD4+ Tregs and angergic T cells and CD8+ T cells especially Tpex vs. Tex, and their dynamic mutual interactions responsible for tolerance induction and maintenance. My current research focus is understanding the cellular and molecular mechanisms underlying type 1 conventional dendritic cells-mediated antigen-specific tolerance, especially in cancers, but also in transplantation, GvHD, EAE, virus infection and fetal and maternal tolerance. Recently, I identified cDC1-specific molecular tolerogenic mechanisms, and currently I am trying to translate my research findings into new therapies that are beneficial to the patients. My belief is that only with a better understanding of how peripheral Ag-specific tolerance is achieved and strengthened, can better cancer immune therapeutic methods be developed. 

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Email: xiangyue@stanford.edu