As artificial intelligence, gene therapies, and clinical-grade digital health tools enter the health care scene, new boundaries are being redrawn around what is possible in medicine. Roughly 10 years into the EHR experiment, how should this technology evolve to take full advantage of these exciting developments? This session will focus on building next-generation capabilities into EHRs to keep pace with developments in technology and science. It will also examine new opportunities for EHRs to deliver patient care that is personalized, predictive, preventive, and sensitive to the social and behavioral influences over a person’s health.