Wnt7a in Pulmonary Angiogenesis

In fall of 2011, within 3 months of the lab’s inception, one simple experiment launched an exciting campaign in exploring the role of Wnt signaling in pulmonary angiogenesis.

Methamphetamine and PAH

During the 1950s through the 1980s three amphetamine-like drugs were commonly prescribed as diet pills, and they worked well.

Wnts in Right Ventricular Failure

Several studies have showed the importance of Wnt signaling for heart tissue repair in the left ventricle, but fewer studies have been done to understand Wnt’s role in right ventricle hypertrophy.

Retinal angiogenesis and PAH

Endothelial cell (EC) dysfunction is an important mediator of the vascular remodeling in PAH. 

Role of HH-10n in idiopathic pulmonary fibrosis

Idiopathic Pulmonary Fibrosis (IPF) is an incurable disease characterized by progressive parenchymal fibrosis resulting in chronic repiratory failure and premature death.

Role of pericytes in PAH

Pulmonary arterial hypertension (PAH) is a life-threatening disorder that is associated with abnormal increase in pulmonary pressures resulting from progressive loss and impaired regeneration of pulmonary microvessels.

Methamphetamine and Pulmonary Disease

Methamphetamine is a sympathomimetic synthetic compound of the phenethylamine class that has become an increasingly popular recreational illicit drug.