What We Do
Our Mission
Our laboratory is dedicated to developing new therapies for ocular diseases. To this end we focus on using the field of MEMS and NEMS in conjunction with cell-based therapies to develop micro-implants. One of our key projects focuses on designing, fabricating, and testing new extended drug delivery devices to treat chronic retinal disease such as macular degeneration and ocular inflammation. Another facet of our work involves surgical instrumentation innovation and modelling retinal disease using finite element analysis.
As this work is interdisciplinary we have researchers and collaborators from multiple backgrounds including electrical engineering, mechanical engineering, biomedical engineering, biology, pharmacology, and medicine.
We have several projects we are working on including extending drug delivery for macular degeneration and uveitis. Our projects can be divided into 4 categories:
We build implantable microdevices using microfabrication techniques and test drug release on the benchtop and in vivo.
We are conducting active research using cell-based systems (encapsulated cells) to deliver therapeutic proteins.
We work on surgical instrumentation and use this to help patients.
We use finite element analysis to model drug delivery in the eye and evaluate the pathogenesis of disease.
Microdevice design and fabrication
a & b) Advanced 3-D printed molds using a Continuous Liquid Interface Printer (CLIP) at the Additive Manufacturing and Prototyping Facility.
c) Microfabricated thin wall intraocular lens with micro-refill valve.
SEM of diffusion filter.
Biocompatibility assay of device.
Learn more about this work:
Read our paper about this work in microdevice design and fabrication in the journal ACS Applied Materials and Interfaces.
Finite element analysis and modeling
Comsol Multiphysics simulation of drug delivery throughout the eye.
Left: DMA stretching of CLIP printed simulated retinal cells
Middle & Right: Corresponding CAD model and COMSOL Multiphysics non-linear simulation
Learn more about this work:
Surgical instrumentation and design and innovation
We design and innovate on new surgical instrumentation for patient care in ophthalmology.
Custom probes for performing vitreous biopsy in clinic.