Facilities

The CRF was installed and launched in 2006 to produce radioisotopes for both clinical and research use.  As of today, the CRF produces over 40 different radiopharmaceuticals and 36 under FDA-approved INDs or RDRC approvals.  The production by the CRF has increased tremendously from 2,300 doses per year in 2006, to over 8,000 doses in 2021.  The CRF has helped support numerous research grants over the years.

The CRF currently employs 13 staff members, including seven radiochemists, and three radiochemistry technicians. Together, they support both the clinical production and translation of research tracers to the clinic. The radiochemists are cross trained on different isotope productions and labelling strategies that are a crucial part of our radiochemistry support provided to Stanford faculty. The CRF staff participates in research projects with faculty who do not have their own radiochemists, and help train new postdocs, graduate students, and scientific staff. 

Equipment at Lucas:

• GE PETtrace 880 Cyclotron
  
• 6 target for ¹¹C, ¹⁸F, ¹³N, and ¹⁵O
• 14 Comecer hot cells
• 2 shielded hoods for manual research
• 6 fume hoods
• GE radiosynthesis modules
• 3 FastLab 2
• 2 TRACERLab FX-FN-Pro
• 4 TRACERLab FX-FN
• 2 TRACERLab FX-FE
• 1 TRACERLab FXC-ME
• 1 TRACERLab FX2-MEI
• 1 TRACERLab FX2-M
• Analytical equipment used for radiochemistry and quality control
• Automated dispensing capabilities for dosing radiopharmaceuticals for human use under cGMP requirements

Since the Lucas facility was commissioned in 2006, the applications for nuclear medicine and cyclotron technologies have significantly evolved.  In early 2024, the CRF will commission an expansion that will add capacity and new technologies at the new location which will include: (1) the new capability of solid targets, which allows for the production of new isotopes including production of long-lived isotopes (2) space and equipment for theragnostic radiolabeling and dispensing for human translation and (3) additional space (3.500 sq ft) to support our growing radiochemistry program.

Equipment at 1701 Page Mill:

• GE PETtrace 890 Cyclotron
• 4 targets fro production of ¹¹C, ¹⁸F
• 2 solid targets for production of ⁶⁸Ga, ⁸⁹Zr, ⁶⁴Cu, and other new isotopes
• 12 Comecer hot cells
• 4 shielded hoods for manual research
• 6 fume hoods
• GE radiosynthesis modules
• 2 FastLab 2
• 1 TRACERLab FX2-MEI
• 3 TRACERLab FX2-M
• 2 TRACERLab FX-N
• Analytical equipment used for radiochemistry and quality control
• Dedicated hood space for extracting isotopes from solid targetry
• Automated dispensing capabilities for dosing radiopharmaceuticals for human use under cGMP requirements